2-Chloro-9-methyl-9H-purin-6-amine
- Product Name
- 2-Chloro-9-methyl-9H-purin-6-amine
- CAS No.
- 7013-21-0
- Chemical Name
- 2-Chloro-9-methyl-9H-purin-6-amine
- Synonyms
- 2-Chloro-9-methyladenine;2-Chloro-6-amino-9-methylpurine;6-Amino-2-chloro-9-methylpurine;2-Chloro-9-methyl-9H-purin-6-amine;9H-Purin-6-amine, 2-chloro-9-methyl-
- CBNumber
- CB41241080
- Molecular Formula
- C6H6ClN5
- Formula Weight
- 183.6
- MOL File
- 7013-21-0.mol
2-Chloro-9-methyl-9H-purin-6-amine Property
- Boiling point:
- 360.9±52.0 °C(Predicted)
- Density
- 1.79±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 1.98±0.10(Predicted)
N-Bromosuccinimide Price
- Product number
- C994120
- Product name
- 2-Chloro-9-methyl-9H-purin-6-amine
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- HCH0363655
- Product name
- 2-CHLORO-9-METHYL-9H-PURIN-6-AMINE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $142.8
- Updated
- 2021/12/16
- Product number
- 0319CB
- Product name
- 2-Chloro-9-methyl-9H-purin-6-amine
- Packaging
- 5g
- Price
- $1357
- Updated
- 2021/12/16
- Product number
- A2746
- Product name
- 2-chloro-9-methyl-9H-Purin-6-amine
- Purity
- 97.00%
- Packaging
- 1G
- Price
- $1940
- Updated
- 2021/12/16
- Product number
- CD11069981
- Product name
- 2-Chloro-9-methyl-9H-purin-6-amine
- Purity
- 95+%
- Packaging
- 10g
- Price
- $2079
- Updated
- 2021/12/16
2-Chloro-9-methyl-9H-purin-6-amine Chemical Properties,Usage,Production
Synthesis
2382-10-7
7013-21-0
2,6-Dichloro-9-methyl-9H-purine (26) (1.01 g, 4.97 mmol) was used as a raw material and mixed with 32% ammonium hydroxide solution (20.4 mL, 164 mmol) in acetonitrile (20 mL). The reaction mixture was stirred at 55 °C for 5.5 hours. Subsequently, 32% ammonium hydroxide solution (20.4 mL, 164 mmol) was added to the reaction system and stirring was continued at 55°C for 19.5 hours. After completion of the reaction, the mixture was evaporated to dryness. The crude product obtained was suspended in methanol and filtered to afford the target compound 2-chloro-9-methyl-9H-purin-6-amine (27) as a white solid (746 mg, 82% yield) with a melting point >300 °C. The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3) δ 8.10 (s, 1H), 7.72 (s, 2H), 3.69 (s, 3H); 13C NMR (101 MHz, CDCl3) δ 156.6 (C), 152.8 (C), 150.8 (C), 141.9 (CH), 117.6 (C), 29.5 ( CH3) confirmed. The mass spectrum (ESI, 20 V) showed a m/z of 184.1 (MH+, 100).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 11, p. 3427 - 3433
2-Chloro-9-methyl-9H-purin-6-amine Preparation Products And Raw materials
Raw materials
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