Ethanone, 2-chloro-1-(3-indolyl)-

Product Name: Ethanone, 2-chloro-1-(3-indolyl)-
CAS No.: 28755-03-5
Chemical Name: Ethanone, 2-chloro-1-(3-indolyl)-
Synonyms: 3CAI;3CAI >=95% (HPLC);3-chloroacetylindole;Akt Inhibitor XIX, 3CAI;Chloromethyl indol-3-yl ketone;3-(Chloroacetyl)-1H-indole 95%;2-Chloro-1-(3-Indolyl)-Ethanone;Ethanone, 2-chloro-1-(3-indolyl)-;Ethanone, 2-chloro-1H-indol-1-yl-;Ethanone, 2-chloro-1-(1H-indol-3-yl)-
CBNumber: CB41247653
Molecular Formula: C10H8ClNO
Formula Weight: 193.63
MOL File: 28755-03-5.mol

More

Less

Ethanone, 2-chloro-1-(3-indolyl)- Property

Melting point:: 212-214 °C(Solv: ethyl ether (60-29-7))
Boiling point:: 379.1±17.0 °C(Predicted)
Density: 1.337±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO: soluble5mg/mL, clear
form: powder
pka: 15.08±0.30(Predicted)
color: yellow to brown

More

Less

Safety

Hazard Codes: Xn
Risk Statements: 22-36
Safety Statements: 26
WGK Germany: 3
HS Code: 2933998090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 124037
Product name: Akt Inhibitor XIX, 3CAI
Packaging: 25mg
Price: $195
Updated: 2023/01/07

Cayman Chemical

Product number: 14303
Product name: 3CAI
Purity: ≥95%
Packaging: 250mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 14303
Product name: 3CAI
Purity: ≥95%
Packaging: 500mg
Price: $166
Updated: 2024/03/01

Cayman Chemical

Product number: 14303
Product name: 3CAI
Purity: ≥95%
Packaging: 1g
Price: $275
Updated: 2024/03/01

TRC

Product number: C382623
Product name: 3-(Chloroacetyl)indole
Packaging: 1g
Price: $290
Updated: 2021/12/16

More

Less

Ethanone, 2-chloro-1-(3-indolyl)- Chemical Properties,Usage,Production

Uses

3-(Chloroacetyl)indole is a reagent used in organic synthesis. Used in the preparation of 1,?2-?dihydroazepino[4,?5-?b]?indoles.

Biological Activity

3cai is a potent allosteric and specific inhibitor of akt, which directly binds with akt1 or akt2 in an atp noncompetitive manner and shows 60% inhibition of akt1 kinase activity at 1 μm [1]. the serine/threonine kinase akt includes three members, akt1, akt2, and akt3. akt plays a critical role in promoting transformation and chemoresistance through inducing proliferation and inhibiting apoptosis. therefore, akt is regarded as a potential target for cancer therapy.

in vitro

3cai (1 and 4 μm) significantly inhibited akt1 kinase activity and decreased expression of akt direct downstream targets including mtor and gsk3β, respectively. 3cai (4 μm) efficiently induced growth inhibition and apoptosis in hct116 or hct29 colon cancer cells [1].

in vivo

3cai (30 mg/kg, oral administration) significantly suppressed colon cancer growth in an in vivo xenograft mouse model and inhibited the expression of akt-target protein such as mtor and gsk3βin hct116 colon tumor tissues [1].

target

akt

IC 50

1 μm

References

1. kim dj, reddy k, kim mo, li y, nadas j, cho yy, et al. (3-chloroacetyl)-indole, a novel allosteric akt inhibitor, suppresses colon cancer growth in vitro and in vivo. cancer prev res (phila). 2011;4(11):1842-51.

Ethanone, 2-chloro-1-(3-indolyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Ethanone, 2-chloro-1-(3-indolyl)- Suppliers

China 52 Ukraine 1 United Kingdom 2 United States 14 Global 69

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 94838
Advantage: 76

Chembest Research Laboratories Limited

Tel: 021-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6011
Advantage: 61

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4863
Advantage: 58

Shanghai Raise Chemical Technology Co.,Ltd

Tel: 15026594951
Fax: 0556-5030632
Email: rs@raise-chem.com
Country: China
ProdList: 3155
Advantage: 55

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66113011 18112977050
Email: cb6@aikonchem.com
Country: China
ProdList: 16687
Advantage: 50

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9926
Advantage: 65

Shanghai Rechem science Co., Ltd.

Tel: 21-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2985
Advantage: 58

Shanghai Chaolan Chemical Technology Center

Tel: QQ:65489617 15618227136
Fax: 21-5161 9052
Email: info@SuperLan-chem.com
Country: China
ProdList: 9737
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131981
Advantage: 58

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4662
Advantage: 60

28755-03-5, Ethanone, 2-chloro-1-(3-indolyl)-Related Search:

Ethanone, 2-chloro-1-(3-indolyl)-

3-chloroacetylindole

2-chloro-1-(1H-indol-3-yl)ethanone(SALTDATA: FREE)

2-Chloro-1-(1H-indol-3-yl)ethan-1-one, 3-(2-Chloroethanoyl)-1H-indole

3CAI

Chloromethyl indol-3-yl ketone

Ethanone, 2-chloro-1-(1H-indol-3-yl)-

Ethanone, 2-chloro-1H-indol-1-yl-

2-Chloro-1-(3-Indolyl)-Ethanone

Akt Inhibitor XIX, 3CAI

Akt Inhibitor XIX, 3CAI - CAS 28755-03-5 - Calbiochem

3-(Chloroacetyl)-1H-indole 95%

3CAI >=95% (HPLC)

Inhibitor,3CAI,inhibit,Akt,Protein kinase B,PKB

28755-03-5