Ravuconazole
- Product Name
- Ravuconazole
- CAS No.
- 182760-06-1
- Chemical Name
- Ravuconazole
- Synonyms
- Rcz;Er-30346;Aids057176;Bms-207147;The health;Bms-207,147;Aids-057176;Ravuconazole;Levaconazole;BMS-207147/Ravuconazole
- CBNumber
- CB41257944
- Molecular Formula
- C22H17F2N5OS
- Formula Weight
- 437.47
- MOL File
- 182760-06-1.mol
Ravuconazole Property
- Melting point:
- 64-66°C
- alpha
- D24 -29.1° (c = 1.03 in methanol)
- Boiling point:
- 674.9±65.0 °C(Predicted)
- Density
- 1.38±0.1 g/cm3(Predicted)
- storage temp.
- -20°C Freezer
- solubility
- DMF: 25 mg/ml; DMF:PBS (pH 7.2) (1:4): 0.25 mg/ml; DMSO: 20 mg/ml; Ethanol: 5 mg/ml
- form
- A crystalline solid
- pka
- 11.62±0.29(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- SML1216
- Product name
- Ravuconazole
- Purity
- ≥97% (NMR)
- Packaging
- 5mg
- Price
- $132
- Updated
- 2024/03/01
- Product number
- SML1216
- Product name
- Ravuconazole
- Purity
- ≥97% (NMR)
- Packaging
- 25MG
- Price
- $520
- Updated
- 2024/03/01
- Product number
- 18750
- Product name
- Ravuconazole
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 18750
- Product name
- Ravuconazole
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $109
- Updated
- 2024/03/01
- Product number
- 18750
- Product name
- Ravuconazole
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $193
- Updated
- 2024/03/01
Ravuconazole Chemical Properties,Usage,Production
Description
Ravuconazole is an orally available triazole fungicide that potently inhibits the growth of a wide range of fungi (MICs range from 25 to 780 ng/ml). Like other azoles, ravuconazole inhibits cytochrome P450 (CYP) isoforms that are involved in ergosterol biosynthesis, interfering with the generation of the fungal and protozoan cell membranes. Ravuconazole specifically inhibits sterol 14α-demethylase (CYP51). As this enzyme is also important in the development of trypanosomes, ravuconazole is effective against T. cruzi infections in animal models of Chagas disease.
Chemical Properties
Off-White Solid
Uses
Ergosterol biosynthesis inhibitor. Antifungal.
Definition
ChEBI: Ravuconazole is a member of the class of triazoles that is 1-butyl-1H-1,2,4-triazole in which the butyl group is substituted at positions 2, 2, and 3 by hydroxy, 2,4-difluorophenyl, and 4-(p-cyanophenyl)-1,3-thiazol-2-yl groups, respectively (the R,R stereoisomer). It exhibits antifungal activity by inhibition of 14alpha demethylase, an enzyme involved in sterol synthesis, resulting in lysis of the fungal cell wall and fungal cell death. (NCIO4) It has a role as an ergosterol biosynthesis inhibitor, an antifungal drug, an EC 1.14.14.154 (sterol 14alpha-demethylase) inhibitor and an antileishmanial agent. It is a member of triazoles, a member of fluorobenzenes, a tertiary alcohol, a member of 1,3-thiazoles and a nitrile.
Ravuconazole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ravuconazole manufacturers
- Product
- 4-[2-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1,2,4-triazol-1-yl)b utan-2-yl]-1,3-thiazol-4-yl]benzonitrile 182760-06-1
- Price
- US $110.00/KG
- Min. Order
- 100g
- Purity
- 99.99%
- Supply Ability
- 5ton/Month
- Release date
- 2021-11-26
- Product
- 4-[2-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1,2,4-triazol-1-yl)b utan-2-yl]-1,3-thiazol-4-yl]benzonitrile 182760-06-1
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- ≥98%
- Supply Ability
- g/kg/Ton
- Release date
- 2019-12-25