Ravuconazole

Product Name: Ravuconazole
CAS No.: 182760-06-1
Chemical Name: Ravuconazole
Synonyms: Rcz;Er-30346;Aids057176;Bms-207147;The health;Bms-207,147;Aids-057176;Rafconazole;Ravuconazole;Levaconazole
CBNumber: CB41257944
Molecular Formula: C22H17F2N5OS
Formula Weight: 437.47
MOL File: 182760-06-1.mol

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Ravuconazole Property

Melting point:: 64-66°C
alpha: D24 -29.1° (c = 1.03 in methanol)
Boiling point:: 674.9±65.0 °C(Predicted)
Density: 1.38±0.1 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: DMF: 25 mg/ml; DMF:PBS (pH 7.2) (1:4): 0.25 mg/ml; DMSO: 20 mg/ml; Ethanol: 5 mg/ml
form: A crystalline solid
pka: 11.62±0.29(Predicted)
color: Off-white to yellow
optical activity: [α]/D -27 to -33°, c =1 in methanol

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1216
Product name: Ravuconazole
Purity: ≥97% (NMR)
Packaging: 5mg
Price: $132
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1216
Product name: Ravuconazole
Purity: ≥97% (NMR)
Packaging: 25MG
Price: $520
Updated: 2024/03/01

Cayman Chemical

Product number: 18750
Product name: Ravuconazole
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 18750
Product name: Ravuconazole
Purity: ≥98%
Packaging: 5mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 18750
Product name: Ravuconazole
Purity: ≥98%
Packaging: 10mg
Price: $193
Updated: 2024/03/01

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Ravuconazole Chemical Properties,Usage,Production

Description

Ravuconazole is an orally available triazole fungicide that potently inhibits the growth of a wide range of fungi (MICs range from 25 to 780 ng/ml). Like other azoles, ravuconazole inhibits cytochrome P450 (CYP) isoforms that are involved in ergosterol biosynthesis, interfering with the generation of the fungal and protozoan cell membranes. Ravuconazole specifically inhibits sterol 14α-demethylase (CYP51). As this enzyme is also important in the development of trypanosomes, ravuconazole is effective against T. cruzi infections in animal models of Chagas disease.

Chemical Properties

Off-White Solid

Uses

Ergosterol biosynthesis inhibitor. Antifungal.

Definition

ChEBI: Ravuconazole is a member of the class of triazoles that is 1-butyl-1H-1,2,4-triazole in which the butyl group is substituted at positions 2, 2, and 3 by hydroxy, 2,4-difluorophenyl, and 4-(p-cyanophenyl)-1,3-thiazol-2-yl groups, respectively (the R,R stereoisomer). It exhibits antifungal activity by inhibition of 14alpha demethylase, an enzyme involved in sterol synthesis, resulting in lysis of the fungal cell wall and fungal cell death. (NCIO4) It has a role as an ergosterol biosynthesis inhibitor, an antifungal drug, an EC 1.14.14.154 (sterol 14alpha-demethylase) inhibitor and an antileishmanial agent. It is a member of triazoles, a member of fluorobenzenes, a tertiary alcohol, a member of 1,3-thiazoles and a nitrile.

Ravuconazole Preparation Products And Raw materials

Raw materials

Preparation Products

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Ravuconazole Suppliers

Canada 1 China 93 India 2 United Kingdom 1 United States 12 Global 109

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
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InvivoChem

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Fax: 708-557-7486
Email: sales@invivochem.cn
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Protheragen-ING

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Country: United States
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Aladdin Scientific

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Email: sales@aladdinsci.com
Country: United States
ProdList: 52924
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TargetMol Chemicals Inc.

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Alfa Chemistry

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Waterstone Technology, LLC

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HONEST JOY HOLDINGS LIMITED

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Cayman Chemical Company

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MedChemExpress

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NE Scientific

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View Lastest Price from Ravuconazole manufacturers

Qiuxian Baitai New Material Co., LTD

Product: 4-[2-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1,2,4-triazol-1-yl)b utan-2-yl]-1,3-thiazol-4-yl]benzonitrile 182760-06-1
Price: US $110.00/KG
Min. Order: 100g
Purity: 99.99%
Supply Ability: 5ton/Month
Release date: 2021-11-26

Career Henan Chemical Co

Product: 4-[2-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1,2,4-triazol-1-yl)b utan-2-yl]-1,3-thiazol-4-yl]benzonitrile 182760-06-1
Price: US $1.00/g
Min. Order: 1g
Purity: ≥98%
Supply Ability: g/kg/Ton
Release date: 2019-12-25

182760-06-1, RavuconazoleRelated Search:

Voriconazole Fosfluconazole

Aids057176

4-[2-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1,2,4-triazol-1-yl)b utan-2-yl]-1,3-thiazol-4-yl]benzonitrile

[R-(R*,R*)]-4-{2-[2-(2,4-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)-propyl]-4-thiazolyl}-benzonitrile

Aids-057176

Benzonitrile, 4-[2-[(1R,2R)-2-(2,4-difluro-phenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazolyl]-

Bms-207,147

Bms-207147

Er-30346

Rcz

Benzonitrile, 4-[2-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazolyl]-

Ravuconazole, BMS-207147

BMS-207147/Ravuconazole

4-(2-((2R,3R)-3-(2,4-Difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)butan-2-yl)thiazol-4-yl)benzonitrile

The health

Ravuconazole

inhibit,ER30346,BMS207147,Ravuconazole,BMS 207147,Fungal,ER 30346,Inhibitor

Levaconazole

Rafconazole

Ravuconazole Impurity 1

Ravuconazole, 10 mM in DMSO

182760-06-1

C22H17F2N5OS

Aromatics

Chiral Reagents

Heterocycles

Inhibitors

Intermediates & Fine Chemicals

Pharmaceuticals