(3R,5R,8S,9S,10S,13S,14S,17R)-17-[(1R)-1,2-dihydroxyethyl]-3,17-dihydr oxy-10,13-dimethyl-2,3,4,5,6,7,8,9,12,14,15,16-dodecahydro-1H-cyclopen ta[a]phenanthren-11-one

Product Name: (3R,5R,8S,9S,10S,13S,14S,17R)-17-[(1R)-1,2-dihydroxyethyl]-3,17-dihydr oxy-10,13-dimethyl-2,3,4,5,6,7,8,9,12,14,15,16-dodecahydro-1H-cyclopen ta[a]phenanthren-11-one
CAS No.: 667-66-3
Chemical Name: (3R,5R,8S,9S,10S,13S,14S,17R)-17-[(1R)-1,2-dihydroxyethyl]-3,17-dihydr oxy-10,13-dimethyl-2,3,4,5,6,7,8,9,12,14,15,16-dodecahydro-1H-cyclopen ta[a]phenanthren-11-one
Synonyms: B-Cortolone;2-Cortolone;β-Cortolone;β-Cortolone D5;5β-pregnan-3α, 17, 20β, 21-tetrol-11-one;5β-PREGNAN-3α, 17, 20β, 21-TETROL-11-ONE;(20R)-3α,17α,20,21-Tetrahydroxy-5β-pregnan-11-one;Pregnan-11-one, 3,17,20,21-tetrahydroxy-, (3α,5β,20R)-;(3R,5R,8S,9S,10S,13S,14S,17R)-17-[(1R)-1,2-dihydroxyethyl]-3,17-dihydr oxy-10,13-dimethyl-2,3,4,5,6,7,8,9,12,14,15,16-dodecahydro-1H-cyclopen ta[a]phenanthren-11-one
CBNumber: CB41260847
Molecular Formula: C21H34O5
Formula Weight: 366.495
MOL File: 667-66-3.mol

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(3R,5R,8S,9S,10S,13S,14S,17R)-17-[(1R)-1,2-dihydroxyethyl]-3,17-dihydr oxy-10,13-dimethyl-2,3,4,5,6,7,8,9,12,14,15,16-dodecahydro-1H-cyclopen ta[a]phenanthren-11-one Property

Melting point:: 249-258oC
Boiling point:: 564.1±50.0 °C(Predicted)
Density: 1.248±0.06 g/cm3(Predicted)
storage temp.: Refrigerator
solubility: Chloroform (Slightly, Heated), Methanol (Slightly, Heated), Pyridine (Slightly)
pka: 13.95±0.70(Predicted)
form: Solid
color: White to Off-White

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC

Product number: C696285
Product name: β-Cortolone
Packaging: 50mg
Price: $595
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 63783
Product name: β-Cortolone
Packaging: 10mg
Price: $490
Updated: 2021/12/16

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(3R,5R,8S,9S,10S,13S,14S,17R)-17-[(1R)-1,2-dihydroxyethyl]-3,17-dihydr oxy-10,13-dimethyl-2,3,4,5,6,7,8,9,12,14,15,16-dodecahydro-1H-cyclopen ta[a]phenanthren-11-one Chemical Properties,Usage,Production

Uses

β-Cortolone is a metabolite of Cortisol (H714615), a steroid hormone, more specifically a glucocorticoid, produced by the zona fasciculata of the adrenal gland. Cortisol is released in response to stress and a low level of blood glucocorticoids. Its primary functions are to increase blood sugar through gluconeogenesis; suppress the immune system; and aid in fat, protein and carbohydrate metabolism.

Definition

ChEBI: Beta-Cortolone is a 21-hydroxy steroid.

(3R,5R,8S,9S,10S,13S,14S,17R)-17-[(1R)-1,2-dihydroxyethyl]-3,17-dihydr oxy-10,13-dimethyl-2,3,4,5,6,7,8,9,12,14,15,16-dodecahydro-1H-cyclopen ta[a]phenanthren-11-one Preparation Products And Raw materials

Raw materials

Preparation Products

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(3R,5R,8S,9S,10S,13S,14S,17R)-17-[(1R)-1,2-dihydroxyethyl]-3,17-dihydr oxy-10,13-dimethyl-2,3,4,5,6,7,8,9,12,14,15,16-dodecahydro-1H-cyclopen ta[a]phenanthren-11-one Suppliers

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667-66-3, (3R,5R,8S,9S,10S,13S,14S,17R)-17-[(1R)-1,2-dihydroxyethyl]-3,17-dihydr oxy-10,13-dimethyl-2,3,4,5,6,7,8,9,12,14,15,16-dodecahydro-1H-cyclopen ta[a]phenanthren-11-oneRelated Search:

5B-PREGNANE-3A-17A-20B-TRIOL*CRYSTALLINE 5BETA-PREGNAN-3ALPHA, 17ALPHA, 20BETA, 21-TETROL-11-ONE-3BETA-D-GLUCURONIDE-20 21-ACETONIDE (3R,5R,8S,9S,10S,13S,14S,17R)-17-[(1R)-1,2-dihydroxyethyl]-3,17-dihydr oxy-10,13-dimethyl-2,3,4,5,6,7,8,9,12,14,15,16-dodecahydro-1H-cyclopen ta[a]phenanthren-11-one 2-HEPTANONE，5-(HYDROXYMETHYL) Menthone 5-BETA-PREGNAN-3-ALPHA, 20-BETA-DIOL

(3R,5R,8S,9S,10S,13S,14S,17R)-17-[(1R)-1,2-dihydroxyethyl]-3,17-dihydr oxy-10,13-dimethyl-2,3,4,5,6,7,8,9,12,14,15,16-dodecahydro-1H-cyclopen ta[a]phenanthren-11-one

B-Cortolone

(20R)-3α,17α,20,21-Tetrahydroxy-5β-pregnan-11-one

2-Cortolone

5β-pregnan-3α, 17, 20β, 21-tetrol-11-one

β-Cortolone

β-Cortolone D5

Pregnan-11-one, 3,17,20,21-tetrahydroxy-, (3α,5β,20R)-

5β-PREGNAN-3α, 17, 20β, 21-TETROL-11-ONE

667-66-3