4-Iodo-1H-indazol-3-ylamine
- Product Name
- 4-Iodo-1H-indazol-3-ylamine
- CAS No.
- 599191-73-8
- Chemical Name
- 4-Iodo-1H-indazol-3-ylamine
- Synonyms
- 3-Amino-4-iodoindazole;4-l0d0-1H-indazol-3-amine;4-iodo-1H-indazol-4-amine;4-iodo-1H-indazol-3-amine;3-Amino-4-iodo-1H-indazole;4-Iodo-1H-indazol-3-ylamine;1H-Indazol-3-aMine, 4-iodo-;3-Amino-4-iodo-1H-indazol...
- CBNumber
- CB41262674
- Molecular Formula
- C7H6IN3
- Formula Weight
- 259.05
- MOL File
- 599191-73-8.mol
4-Iodo-1H-indazol-3-ylamine Property
- Melting point:
- 154-155°
- Boiling point:
- 452.2±25.0 °C(Predicted)
- Density
- 2.168±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- form
- Crystalline Solid
- pka
- 13.85±0.40(Predicted)
- color
- Off-white to brown
Safety
- HazardClass
- IRRITANT
- HS Code
- 29339980
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- I706363
- Product name
- 4-Iodo-1H-indazol-3-amine
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- I706363
- Product name
- 4-Iodo-1H-indazol-3-amine
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- I706363
- Product name
- 4-Iodo-1H-indazol-3-amine
- Packaging
- 500mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- 3H30-H-11
- Product name
- 3-Amino-4-iodo-1H-indazole
- Packaging
- 1g
- Price
- $64
- Updated
- 2021/12/16
- Product number
- FA150903
- Product name
- 3-Amino-4-iodo-1H-indazole
- Packaging
- 100mg
- Price
- $76
- Updated
- 2021/12/16
4-Iodo-1H-indazol-3-ylamine Chemical Properties,Usage,Production
Synthesis
79544-29-9
599191-73-8
General procedure for the synthesis of 3-amino-4-iodoindazole from 2-fluoro-6-iodobenzonitrile: 500 mg of 2-fluoro-6-iodobenzonitrile and 1.3 ml of 85% hydrazine hydrate were dissolved in 10 ml of n-butanol and heated to 110 °C. The reaction mixture was stirred for 6 hours and then cooled to room temperature. Liquid-liquid separation was carried out by adding water and ethyl acetate. The aqueous phase was extracted with ethyl acetate and the combined organic phases were washed with saturated sodium chloride solution, dried over anhydrous sodium sulfate, filtered and concentrated to give 502 mg of 4-iodo-1H-indazol-3-amine as a brown solid in 96% yield.1H NMR (300 MHz, DMSO-d6) δ (ppm): 5.05 (s, 2H), 6.90-6.96 (m, 1H), 7.29 (d, J = 8.1 Hz, 1H), 7.34 (d, J = 7.5 Hz, 1H), 11.80 (s, 1H).
References
[1] ACS Medicinal Chemistry Letters, 2014, vol. 5, # 5, p. 592 - 597
[2] Patent: EP3112351, 2017, A1. Location in patent: Paragraph 0029
[3] Organic Process Research and Development, 2009, vol. 13, # 6, p. 1419 - 1425
[4] European Journal of Medicinal Chemistry, 2015, vol. 104, p. 139 - 147
[5] Journal of Medicinal Chemistry, 2007, vol. 50, # 7, p. 1584 - 1597
4-Iodo-1H-indazol-3-ylamine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Iodo-1H-indazol-3-ylamine manufacturers
- Product
- 4-Iodo-1H-indazol-3-ylamine 599191-73-8
- Price
- US $8.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 100kg
- Release date
- 2019-08-05