ANKAFLAVIN
Description Anti-cancer Activity- Product Name
- ANKAFLAVIN
- CAS No.
- 50980-32-0
- Chemical Name
- ANKAFLAVIN
- Synonyms
- ANKAFLAVIN;Monascus flavan;Anti-cancer Activity;Ankaflavin in Acetonitrile;2H-Furo[3,2-g][2]benzopyran-2,9(3H)-dione, 3a,4,8,9a-tetrahydro-9a-methyl-3-(1-oxooctyl)-6-(1E)-1-propen-1-yl-, (3S,3aR,9aR)-
- CBNumber
- CB41267972
- Molecular Formula
- C23H30O5
- Formula Weight
- 386.48
- MOL File
- 50980-32-0.mol
ANKAFLAVIN Property
- Boiling point:
- 590.7±50.0 °C(Predicted)
- Density
- 1.15±0.1 g/cm3(Predicted)
- storage temp.
- 4°C, protect from light
- solubility
- Soluble in DMSO
- form
- Solid
- pka
- 10.75±0.60(Predicted)
- color
- Light yellow to yellow
- InChIKey
- AQTJNEHGKRUSLT-ODTNPMSZSA-N
- SMILES
- C1(/C=C/C)OCC2C(=O)[C@]3(C)OC(=O)[C@H](C(=O)CCCCCCC)[C@@]3([H])CC=2C=1
N-Bromosuccinimide Price
- Product number
- XA165909
- Product name
- Ankaflavin
- Packaging
- 2mg
- Price
- $500
- Updated
- 2021/12/16
- Product number
- CS-0062873
- Product name
- Ankaflavin
- Packaging
- 1mg
- Price
- $550
- Updated
- 2021/12/16
- Product number
- 8323CV
- Product name
- Ankaflavin
- Packaging
- 2mg
- Price
- $725
- Updated
- 2021/12/16
- Product number
- XA165909
- Product name
- Ankaflavin
- Packaging
- 5mg
- Price
- $800
- Updated
- 2021/12/16
- Product number
- orb594586
- Product name
- Ankaflavin
- Packaging
- 5mg
- Price
- $923.1
- Updated
- 2021/12/16
ANKAFLAVIN Chemical Properties,Usage,Production
Description
Ankaflavin (AK), isolated from Monascus-Fermented red rice, is a PPARγ agonist with anti-inlfammatory activity. Ankaflavin is an active compound having anti-inflammatory, anti-cancer, antiatherosclerotic, and hypolipidemic effects.
Anti-cancer Activity
Ankaflavin was found to be toxic to human cancer cell lines Hep G2 and A549 with a similar IC50 value of 15 μg/mL, while it posed no significant toxicity to normal MRC-5 and WI-38 cells at the same concentration.Ankaflavin exhibits selective cytotoxic effect and induces cell death on cancer cells.
Description
Ankaflavin is a microbial metabolite that has been found in M. ruber and has diverse biological activities.1,2,3 It induces cytotoxicity in HepG2 hepatic carcinoma and A549 lung cancer cells (IC50 = ~15 µg/ml for both).1 Ankaflavin (15 µg/ml) induces cell cycle arrest at the G0 phase in HepG2 cells. It reduces nitric oxide (NO) production in LPS-stimulated RAW 264.7 macrophages when used at concentrations of 5, 10, and 15 µg/ml.2 Ankaflavin (10 µM) increases lipolysis in 3T3-L1 adipocytes matured by isobutylmethylxanthine (IBMX; Item No. 13347), dexamethasone (Item No. 11015), and insulin.3 In vivo, ankaflavin (5 mg/kg per day) reduces blood glucose and serum insulin levels in mice fed a high-fat diet.WARNING This product is not for human or veterinary use.
ANKAFLAVIN Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from ANKAFLAVIN manufacturers
- Product
- Anti-cancer Activity 50980-32-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 85.0-99.8%
- Supply Ability
- 20 tons
- Release date
- 2019-12-23