ChemicalBook > CAS DataBase List > 1H-Benzimidazole,2-chloro-4-fluoro-(9CI)

1H-Benzimidazole,2-chloro-4-fluoro-(9CI)

Uses Application

Product Name: 1H-Benzimidazole,2-chloro-4-fluoro-(9CI)
CAS No.: 256519-11-6
Chemical Name: 1H-Benzimidazole,2-chloro-4-fluoro-(9CI)
Synonyms: 2-Chloro-4-fluorobenzimidazole;2-Chloro-4-fluoro-1H-benzimidazole;1H-Benzimidazole, 2-chloro-7-fluoro-;1H-BENZIMIDAZOLE, 2-CHLORO-4-FLUORO-;2-chloro-4-fluoro-1H-1,3-benzodiazole;2-Chloro-7-fluoro-1H-benzo[d]imidazole;2-Chloro-4-fluoro-1H-benzo[d]imidazole;1H-Benzimidazole,2-chloro-4-fluoro-(9CI)
CBNumber: CB41276352
Molecular Formula: C7H4ClFN2
Formula Weight: 170.57
MOL File: 256519-11-6.mol

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1H-Benzimidazole,2-chloro-4-fluoro-(9CI) Property

Boiling point:: 332.9±34.0 °C(Predicted)
Density: 1.533±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 7.60±0.30(Predicted)
form: crystalline powder
color: Pale cream

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C584895
Product name: 2-Chloro-4-fluoro-1H-benzo[d]imidazole
Packaging: 50mg
Price: $95
Updated: 2021/12/16

TRC

Product number: C584895
Product name: 2-Chloro-4-fluoro-1H-benzo[d]imidazole
Packaging: 250mg
Price: $250
Updated: 2021/12/16

TRC

Product number: C584895
Product name: 2-Chloro-4-fluoro-1H-benzo[d]imidazole
Packaging: 25mg
Price: $55
Updated: 2021/12/16

Apolloscientific

Product number: PC501474
Product name: 2-Chloro-4-fluoro-1H-benzimidazole
Packaging: 250mg
Price: $56
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0314246
Product name: 2-CHLORO-4-FLUORO-1H-BENZO[D]IMIDAZOLE
Purity: 95.00%
Packaging: 1G
Price: $1566.18
Updated: 2021/12/16

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1H-Benzimidazole,2-chloro-4-fluoro-(9CI) Chemical Properties,Usage,Production

Uses

2-Chloro-4-fluoro-(9CI)-1H-benzimidazole is a pharmaceutical intermediate that can be obtained by first preparing 4-fluoro-1H-benzimidazole-2(3H)-one from 3-fluorophenyl-1,2-diamine, followed by chlorination. It has been reported in the literature that it can be used to prepare ATR kinase inhibitors.

Application

2-Chloro-4-fluoro-(9CI)-1H-benzimidazole can be used to prepare 4-fluoro-N-methyl-1-{4-[(3R)-3-methylmorpholin-4-yl]-6-[1-((R)-S-methylsulfonylimino)cyclopropyl]pyrimidin-2-yl}-1H-benzimidazole-2-amine and 4-fluoro-N-methyl-1-{4-[(3R)-3-methylmorpholin-4-yl]-6-[1-((S)-S-methylsulfonylimino)cyclopropyl]pyrimidin-2-yl}-1H-benzimidazole-2-amine. These two compounds have important applications in the treatment of proliferative diseases (such as cancer), particularly in diseases mediated by ataxia-telangiectasia mutations and RAD-3-related protein kinase inhibitors (commonly known as ATRs).

1H-Benzimidazole,2-chloro-4-fluoro-(9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

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