1H-Benzimidazole,2-chloro-4-fluoro-(9CI)
Uses Application- Product Name
- 1H-Benzimidazole,2-chloro-4-fluoro-(9CI)
- CAS No.
- 256519-11-6
- Chemical Name
- 1H-Benzimidazole,2-chloro-4-fluoro-(9CI)
- Synonyms
- 2-Chloro-4-fluorobenzimidazole;2-Chloro-4-fluoro-1H-benzimidazole;1H-Benzimidazole, 2-chloro-7-fluoro-;1H-BENZIMIDAZOLE, 2-CHLORO-4-FLUORO-;2-chloro-4-fluoro-1H-1,3-benzodiazole;2-Chloro-7-fluoro-1H-benzo[d]imidazole;2-Chloro-4-fluoro-1H-benzo[d]imidazole;1H-Benzimidazole,2-chloro-4-fluoro-(9CI)
- CBNumber
- CB41276352
- Molecular Formula
- C7H4ClFN2
- Formula Weight
- 170.57
- MOL File
- 256519-11-6.mol
1H-Benzimidazole,2-chloro-4-fluoro-(9CI) Property
- Boiling point:
- 332.9±34.0 °C(Predicted)
- Density
- 1.533±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 7.60±0.30(Predicted)
- form
- crystalline powder
- color
- Pale cream
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C584895
- Product name
- 2-Chloro-4-fluoro-1H-benzo[d]imidazole
- Packaging
- 25mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- C584895
- Product name
- 2-Chloro-4-fluoro-1H-benzo[d]imidazole
- Packaging
- 50mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- C584895
- Product name
- 2-Chloro-4-fluoro-1H-benzo[d]imidazole
- Packaging
- 250mg
- Price
- $250
- Updated
- 2021/12/16
- Product number
- PC501474
- Product name
- 2-Chloro-4-fluoro-1H-benzimidazole
- Packaging
- 250mg
- Price
- $56
- Updated
- 2021/12/16
- Product number
- 3H31-7-0X
- Product name
- 2-Chloro-4-fluoro-1H-benzimidazole
- Packaging
- 250mg
- Price
- $112
- Updated
- 2021/12/16
1H-Benzimidazole,2-chloro-4-fluoro-(9CI) Chemical Properties,Usage,Production
Uses
2-Chloro-4-fluoro-(9CI)-1H-benzimidazole is a pharmaceutical intermediate that can be obtained by first preparing 4-fluoro-1H-benzimidazole-2(3H)-one from 3-fluorophenyl-1,2-diamine, followed by chlorination. It has been reported in the literature that it can be used to prepare ATR kinase inhibitors.
Application
2-Chloro-4-fluoro-(9CI)-1H-benzimidazole can be used to prepare 4-fluoro-N-methyl-1-{4-[(3R)-3-methylmorpholin-4-yl]-6-[1-((R)-S-methylsulfonylimino)cyclopropyl]pyrimidin-2-yl}-1H-benzimidazole-2-amine and 4-fluoro-N-methyl-1-{4-[(3R)-3-methylmorpholin-4-yl]-6-[1-((S)-S-methylsulfonylimino)cyclopropyl]pyrimidin-2-yl}-1H-benzimidazole-2-amine. These two compounds have important applications in the treatment of proliferative diseases (such as cancer), particularly in diseases mediated by ataxia-telangiectasia mutations and RAD-3-related protein kinase inhibitors (commonly known as ATRs).
1H-Benzimidazole,2-chloro-4-fluoro-(9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
1H-Benzimidazole,2-chloro-4-fluoro-(9CI) Suppliers
- Tel
- 021-31261262/ 49 (0)17662837245
- Fax
- (0)21-33250524
- sales@novochemy.com
- Country
- Germany
- ProdList
- 6328
- Advantage
- 58