Maropitant citrate hydrate

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Maropitant citrate hydrate

Product Name: Maropitant citrate hydrate
CAS No.: 359875-09-5
Chemical Name: Maropitant citrate hydrate
Synonyms: 2-HYDROXYPROPANE-1,2,3-TRICARBOXYLIC ACID;ethyl[(1R)-1-[(2R)-oxolan-2-yl]-2-phenylethyl]amine;4-(4-fluorophenyl)-1-[4-(1,2,4-triazol-1-yl)butyl]-3,6-dihydro-2H-pyridine;(7S,8S)-7-benzhydryl-N-[(2-methoxy-5-tert-butyl-phenyl)methyl]-1-azabicyclo[2.2.2]octan-8-amine;ACIDUM CITRICUM ANHYDRICUM;Maropitant citrate hydrate;(2S,3S)-N-(5-tert-butyl-2-methoxybenzyl)-2-(diphenylmethyl)-...;(2S,3S)-2-benzhydryl-N-[(5-tert-butyl-2-methoxyphenyl)methyl]-1-azabicyclo[2.2.2]octan-3-amine,2-hydroxypropane-1,2,3-tricarboxylic acid,hydrate;FEMA 2306;CT SUPPLEMENT
CBNumber: CB4127749
Molecular Formula: C38H48N2O8
Formula Weight: 660.81
MOL File: 359875-09-5.mol

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Maropitant citrate hydrate Property

Melting point:: 153-159 °C(lit.)
Flash point:: 100 °C
storage temp.: 2-8°C
solubility: H₂O: 1 M at 20 °C, clear, colorless
form: white to off-white crystalline powder
Water Solubility: Water: 3 mg/mL (4.42 mM)
InChI: InChI=1/C32H40N2O.C6H8O7/c1-32(2,3)27-15-16-28(35-4)26(21-27)22-33-30-25-17-19-34(20-18-25)31(30)29(23-11-7-5-8-12-23)24-13-9-6-10-14-24;7-3(8)1-6(13,5(11)12)2-4(9)10/h5-16,21,25,29-31,33H,17-20,22H2,1-4H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/t30-,31-;/s3
InChIKey: XDZPFSKCXRGRIO-OHTRWSNQNA-N
SMILES: C(O)(C(=O)O)(CC(=O)O)CC(=O)O.C(C1C=CC=CC=1)(C1C=CC=CC=1)[C@@H]1N2CCC(CC2)[C@@H]1NCC1C=C(C(C)(C)C)C=CC=1OC |&1:26,33,r|
CAS DataBase Reference: 359875-09-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,T
Risk Statements: 41-42/43-36/37/38-25
Safety Statements: 26-39-45-36/37-22
RIDADR: UN 3284 6.1/PG 3
WGK Germany: 1
RTECS: GE7350000
F: 9

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H318Causes serious eye damage

H373May cause damage to organs through prolonged or repeated exposure

H400Very toxic to aquatic life

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P314Get medical advice/attention if you feel unwell.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 77981
Product name: CT Supplement
Purity: for microbiology
Packaging: 5amp
Price: $145
Updated: 2024/03/01

American Custom Chemicals Corporation

Product number: CHM0992497
Product name: CT SUPPLEMENT
Purity: 95.00%
Packaging: 5MG
Price: $502.05
Updated: 2021/12/16

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Maropitant citrate hydrate Chemical Properties,Usage,Production

Description

Maropitant citrate hydrate is a specific neurokinin-1 (NK-1) receptor antagonist that selectively inhibits the production of substance P, a mediator involved in signalling vomiting. Maropitant citrate was therefore originally used to treat vomiting in dogs and cats. Currently, it is also used as an adjunct to visceral analgesia in dogs and cats, and in other species such as horses and birds.

Uses

Anti-emetic.

Pharmacokinetics

The maximum, minimum, and average concentrations of maropitant achieved at steady state were 375.5 ± 200, 16.8 ± 7.7, and 73.5 ± 45.1 ng/ml, respectively. The terminal elimination half-life was 11.6 ± 1.4 hr, and the accumulation index was 1.3 ± 0.07. Heart rate decreased between Day 1 and Day 5 (p = .005), with three horses having heart rates of 20 beats per minute and atrioventricular block on Day 5. Pharmacokinetics of repeated maropitant administration suggests the drug could be considered for use in healthy horses.

Veterinary Drugs and Treatments

Maropitant citrate injectable solution is indicated for the prevention and treatment of acute vomiting in dogs; maropitant citrate tablets are indicated for the prevention of acute vomiting and the prevention of vomiting due to motion sickness in dogs. Both are also used extra-label in cats.

Maropitant citrate hydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Maropitant citrate hydrate manufacturers

HangZhou RunYan Pharma Technology Co.,LTD.

Product: Maropitant Citrate 359875-09-5
Price: US $0.00-0.00/MG
Min. Order: 10MG
Purity: 99% HPLC
Supply Ability: 10000
Release date: 2024-09-20

Hebei Yanxi Chemical Co., Ltd.

Product: Maropitant Citrate 359875-09-5
Price: US $20.00-1.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 10 tons
Release date: 2023-11-23

Henan Fengda Chemical Co., Ltd

Product: Maropitant citrate hydrate 359875-09-5
Price: US $8.00-0.80/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-08

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Maropitant citrate hydrate

ethyl[(1R)-1-[(2R)-oxolan-2-yl]-2-phenylethyl]amine

Maropitant citrate [USAN]

(2S,3S)-2-benzhydryl-N-[(5-tert-butyl-2-methoxyphenyl)methyl]-1-azabicyclo[2.2.2]octan-3-amine,2-hydroxypropane-1,2,3-tricarboxylic acid,hydrate

Maropitant Citrate USP/EP/BP

(2S,3S)-N-(5-tert-butyl-2-methoxybenzyl)-2-(diphenylmethyl)-...

Maropitant citrate monohydrateQ: What is Maropitant citrate monohydrate Q: What is the CAS Number of Maropitant citrate monohydrate

TIANFU CHEM---CT SUPPLEMENT

Malopitan citrate

(2S,3S)-2-Benzhydryl-N-(5-(tert-butyl)-2-methoxybenzyl)quinuclidin-3-amine 2-hydroxypropane-1,2,3-tricarboxylate hydrate

(2S,3S)-2-Benzhydryl-N-(5-tert-butyl-2-methoxybenzyl)quinuclidin-3-amine citrate monohydrate

Maropitant Citrate Monohydrate

Maropitan citrate

Shuwotini DZD9008

Pafolacianine Impurity 4

359875-09-5

C32H40N2OC6H8O7H2O

C38H50N2O9

Al2H2O4

C23H29FN4O7

API

359875-09-5