1(2H)-Pyridineaceticacid,2-imino-(9CI)
- Product Name
- 1(2H)-Pyridineaceticacid,2-imino-(9CI)
- CAS No.
- 126202-06-0
- Chemical Name
- 1(2H)-Pyridineaceticacid,2-imino-(9CI)
- Synonyms
- 1(2H)-Pyridineacetic acid, 2-imino-;2-(2-Iminopyridin-1(2H)-yl)acetic acid;1(2H)-Pyridineaceticacid,2-imino-(9CI)
- CBNumber
- CB41294066
- Molecular Formula
- C7H8N2O2
- Formula Weight
- 152.15
- MOL File
- 126202-06-0.mol
1(2H)-Pyridineaceticacid,2-imino-(9CI) Property
- Melting point:
- 257-258 °C
- Boiling point:
- 308.0±44.0 °C(Predicted)
- Density
- 1.28±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 2.78±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
N-Bromosuccinimide Price
- Product number
- I436003
- Product name
- 2-(2-Iminopyridin-1(2H)-yl)aceticAcid
- Packaging
- 500mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- CHM1000412
- Product name
- (2-IMINO-2H-PYRIDIN-1-YL)-ACETIC ACID
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.65
- Updated
- 2021/12/16
- Product number
- 133244
- Product name
- 2-(2-Iminopyridin-1(2H)-yl)acetic acid
- Purity
- 97%
- Packaging
- 5g
- Price
- $931
- Updated
- 2021/12/16
- Product number
- 133244
- Product name
- 2-(2-Iminopyridin-1(2H)-yl)acetic acid
- Purity
- 97%
- Packaging
- 10g
- Price
- $1350
- Updated
- 2021/12/16
- Product number
- 126202060
- Product name
- 2-(2-Iminopyridin-1(2H)-yl)aceticacid
- Packaging
- 25g
- Price
- $1474
- Updated
- 2021/12/16
1(2H)-Pyridineaceticacid,2-imino-(9CI) Chemical Properties,Usage,Production
Uses
2-(2-Iminopyridin-1(2H)-yl)acetic acid is a useful chemical in the preparation of organoselenium imidazo[1,2-a]pyridine compounds, which were studied for their antimicrobial properties.
Synthesis
504-29-0
79-11-8
126202-06-0
1. dissolve chloroacetic acid: add triethylamine (6.12 mL, 44 mmol) dropwise to water (6 mL) at room temperature and stir until chloroacetic acid (3.67 g, 38.8 mmol) is completely dissolved. 2. addition of 2-aminopyridine: 2-aminopyridine (4.3 g, 46 mmol) was added to the above solution, the reaction mixture was heated to 90 °C and refluxed for 5 hours. 3. Precipitation of Intermediate 2a: After completion of the reaction, cooled to room temperature, ethanol was added and the precipitate was precipitated by stirring at 5 °C for 2 hours. Filtered, washed with cold ethanol (4 mL) and dried to give Intermediate 2a (5.3 g, 89% yield). 4. Dissolve Intermediate 2a: Intermediate 2a (5.3 g, 34.8 mmol) was dissolved in toluene (25 mL). 5. Dropwise addition of phosphorus trichloride: Under reflux conditions, phosphorus trichloride (9.7 mL, 104 mmol) was added dropwise to the above solution and reflux was continued for 16 hours. 6. Post-treatment: After completion of the reaction, cool to room temperature, add cold water (100 mL) and stir for 15 minutes. Separate the aqueous layer, neutralize with 10% NaOH aqueous solution and filter the precipitate precipitated. The precipitate was dissolved in dichloromethane and the aqueous phase was extracted with dichloromethane (4 x 20 mL). The organic layers were combined, washed with brine, dried over anhydrous sodium sulfate and concentrated in vacuum to give a brown powder. 7. Purification: Purified by silica gel column chromatography using hexane:ethyl acetate (90:10) as eluent to obtain 2-chloroimidazo[1,2-a]pyridine (3a) (5.2 g, 98% yield). Note: 2-chloro-7-methylimidazo[1,2-a]pyridine (3b) can be prepared by the same method by substituting 2-amino-4-methylpyridine for 2-aminopyridine.
References
[1] European Journal of Medicinal Chemistry, 2016, vol. 123, p. 916 - 924
[2] New Journal of Chemistry, 2017, vol. 41, # 8, p. 2919 - 2926
[3] Patent: CN103508930, 2016, B. Location in patent: Paragraph 0330-0333
[4] Patent: KR2016/1508, 2016, A. Location in patent: Paragraph 0140-0143
[5] Tetrahedron Letters, 2012, vol. 53, # 3, p. 297 - 300
1(2H)-Pyridineaceticacid,2-imino-(9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
1(2H)-Pyridineaceticacid,2-imino-(9CI) Suppliers
- Tel
- 13564638271
- shhjiang1977@163.com
- Country
- China
- ProdList
- 2989
- Advantage
- 55
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 13661490451 13671802554
- Fax
- QQ627235036
- xyfn@163.com
- Country
- China
- ProdList
- 582
- Advantage
- 58
- Tel
- 15026866316
- 180642609@qq.com
- Country
- China
- ProdList
- 4968
- Advantage
- 58
- Tel
- 18061688856
- easichem@126.com
- Country
- China
- ProdList
- 477
- Advantage
- 58
- Tel
- 18642120371
- 2837458851@qq.com
- Country
- China
- ProdList
- 7963
- Advantage
- 58
- Tel
- 010-60605840 15801484223;
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 29757
- Advantage
- 58
- Tel
- 16773308882
- 927608786@qq.com
- Country
- China
- ProdList
- 3051
- Advantage
- 58
- Tel
- 17715136450
- 2439673774@qq.com
- Country
- China
- ProdList
- 15647
- Advantage
- 58
- Tel
- 18317763565
- 18317763565@163.com
- Country
- China
- ProdList
- 7891
- Advantage
- 58