ChemicalBook > CAS DataBase List > 5-Isoxazolamine,3-(trifluoromethyl)-(9CI)

5-Isoxazolamine,3-(trifluoromethyl)-(9CI)

Product Name: 5-Isoxazolamine,3-(trifluoromethyl)-(9CI)
CAS No.: 108655-63-6
Chemical Name: 5-Isoxazolamine,3-(trifluoromethyl)-(9CI)
Synonyms: 3-(Trifluoromethyl)-5-isoxazolamine;3-TRIFLUOROMETHYL-5-AMINOISOXAZOLE;3-(TrifluoroMethyl)isoxazol-5-aMine;3-Trifluoromethyl-isoxazol-5-ylamine;5-Amino-3-(trifluoromethyl)isoxazole;5-Isoxazolamine, 3-(trifluoromethyl)-;3-(trifluoromethyl)-1,2-oxazol-5-amine;5-Amino-3-(trifluoromethyl)isoxazole 95+%;5-Isoxazolamine,3-(trifluoromethyl)-(9CI);3-(Trifluoromethyl)-1,2-oxazol-5-amine, 5-Amino-3-(trifluoromethyl)-1,2-oxazole
CBNumber: CB41302392
Molecular Formula: C4H3F3N2O
Formula Weight: 152.07
MOL File: 108655-63-6.mol

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5-Isoxazolamine,3-(trifluoromethyl)-(9CI) Property

Melting point:: 53-55°
Boiling point:: 96-98.5 °C(Press: 0.13 Torr)
Density: 1.502±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: -2.65±0.10(Predicted)
Appearance: Off-white to light yellow Solid

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Safety

HazardClass: IRRITANT
HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: T896915
Product name: 3-(Trifluoromethyl)isoxazol-5-amine
Packaging: 100mg
Price: $65
Updated: 2021/12/16

Matrix Scientific

Product number: 047185
Product name: 3-(Trifluoromethyl)-5-isoxazolamine
Purity: >95%
Packaging: 500mg
Price: $98
Updated: 2021/12/16

Matrix Scientific

Product number: 047185
Product name: 3-(Trifluoromethyl)-5-isoxazolamine
Purity: >95%
Packaging: 1g
Price: $150
Updated: 2021/12/16

Apolloscientific

Product number: PC200153
Product name: 5-Amino-3-(trifluoromethyl)isoxazole
Purity: 95+%
Packaging: 500mg
Price: $165
Updated: 2021/12/16

Apolloscientific

Product number: PC200153
Product name: 5-Amino-3-(trifluoromethyl)isoxazole
Purity: 95+%
Packaging: 1g
Price: $215
Updated: 2021/12/16

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5-Isoxazolamine,3-(trifluoromethyl)-(9CI) Chemical Properties,Usage,Production

Synthesis

151-50-8

117341-57-8

108655-63-6

To a suspension of potassium cyanide (1.90 g, 29.1 mmol) in methanol (35 mL) was added dropwise a methanolic solution (72 mL) of 3-bromo-1,1,1-trifluoropropan-2-oxime (5.00 g, 24.3 mmol) and the reaction was carried out at room temperature. The reaction mixture was stirred continuously for 3 hours at room temperature. Upon completion of the reaction, the solvent was removed by rotary evaporator and the residue was dissolved in ethyl acetate and stirred at room temperature. The resulting potassium bromide solid was removed by filtration and the filtrate was concentrated by rotary evaporation to give the crude product. The crude product was purified by silica gel column chromatography (Biotage: 25M, eluent 10% to 60% ethyl acetate/hexane, elution volume 550 mL). The pure fraction was collected and concentrated to afford the target product 3-(trifluoromethyl)isoxazol-5-amine (1.38 g, 37% yield). Mass spectrum (ESI) m/z: 153.0 ([M-H]-).

References

[1] Patent: WO2008/33999, 2008, A2. Location in patent: Page/Page column 85

5-Isoxazolamine,3-(trifluoromethyl)-(9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5-Isoxazolamine,3-(trifluoromethyl)-(9CI) manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 3-(Trifluoromethyl)isoxazol-5-amine 108655-63-6
Price: US $1.60-6.60/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-19

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