marcfortine A
- Product Name
- marcfortine A
- CAS No.
- 75731-43-0
- Chemical Name
- marcfortine A
- Synonyms
- UK 111866;marcfortine A;Spiro[4H,8H-[1,4]dioxepino[2,3-g]indole-8,2'(3'H)-[1H,4H-3a,9a](iminomethano)cyclopenta[b]quinolizine]-9,11'(10H)-dione, 6',7',8',9',10',10'a-hexahydro-1',1',4,4,12'-pentamethyl-, (2'R,3'aS,9'aS,10'aS)-
- CBNumber
- CB41323193
- Molecular Formula
- C28H35N3O4
- Formula Weight
- 477.602
- MOL File
- 75731-43-0.mol
marcfortine A Property
- Melting point:
- 245 °C
- Boiling point:
- 660.6±55.0 °C(Predicted)
- Density
- 1.33±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Methanol: soluble
- form
- A solid
- pka
- 12.05±0.60(Predicted)
N-Bromosuccinimide Price
- Product number
- 23486
- Product name
- Marcfortine A
- Purity
- ≥99%
- Packaging
- 1mg
- Price
- $340
- Updated
- 2024/03/01
- Product number
- 23486
- Product name
- Marcfortine A
- Purity
- ≥99%
- Packaging
- 5mg
- Price
- $1523
- Updated
- 2024/03/01
- Product number
- M2374-75
- Product name
- Marcfortine A
- Packaging
- 1mg
- Price
- $588
- Updated
- 2021/12/16
- Product number
- M197305
- Product name
- MarcfortineA
- Packaging
- 2.5mg
- Price
- $625
- Updated
- 2021/12/16
marcfortine A Chemical Properties,Usage,Production
Description
Marcfortine A is an indole alkaloid originally isolated from P. roqueforti. It has nematocidal activity against the parasitic nematode H. contortus (LD99 = 0.06 μg/ml) and inhibits motility of adult worms (EC50 = 2 μM)., Marcfortine A eliminates H. contortus, T. colubriformis, and O. ostertagi from experimentally infected jirds (ED95s = 0.33, 0.11, and 2.5 mg/animal, respectively). It dose-dependently inhibits nicotine-induced calcium mobilization in SH-SY5Y and TE-671 cells expressing α3 subunit-containing human nicotinic acetylcholine receptors (nAChRs) and muscle-type nAChRs, respectively.
Uses
Marcfortine A is an indole alkaloid, isolated from Aspergillus and Pencillium species, with potent nematocidal activity. The marcfortines are structurally related to paraherquamides and are thought to act by blocking cholinergic neuromuscular transmission.
Uses
Marcfortine A is an indole alkaloid isolated from Aspergillus and Pencillium species.
marcfortine A Preparation Products And Raw materials
Raw materials
Preparation Products
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