ChemicalBook > CAS DataBase List > Lexithromycin
Lexithromycin
- Product Name
- Lexithromycin
- CAS No.
- 53066-26-5
- Chemical Name
- Lexithromycin
- Synonyms
- Wy 48314;Lexithromycin;Erythromycin A-E-oxime;Azithromycin Impurity 4;erythromycin A methoxime;Azithromycin Impurity 31;Erythromycin A 9-Methoxime;Erythromycin, 9-(O-methyloxime);9-(Methoxyimino)-9-deoxoerythromycin;ErythroMycin A 9-MethoxiMe, Wy 48314
- CBNumber
- CB41327717
- Molecular Formula
- C38H70N2O13
- Formula Weight
- 762.97
- MOL File
- 53066-26-5.mol
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Lexithromycin Property
- Melting point:
- >115°C (dec.)
- Boiling point:
- 824.6±75.0 °C(Predicted)
- Density
- 1.26±0.1 g/cm3(Predicted)
- storage temp.
- Hygroscopic, -20°C Freezer, Under inert atmosphere
- solubility
- Chloroform (Slightly), DMSO (Slightly)
- pka
- 13.19±0.70(Predicted)
- form
- Solid
- color
- White to Off-White
- Stability:
- Hygroscopic
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 22002
- Product name
- Lexithromycin
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $171
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 22002
- Product name
- Lexithromycin
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $760
- Updated
- 2024/03/01
ChemScene
- Product number
- CS-0026970
- Product name
- Lexithromycin
- Purity
- 98.80%
- Packaging
- 100mg
- Price
- $1650
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- API0011780
- Product name
- LEXITHROMYCIN
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.99
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0026970
- Product name
- Lexithromycin
- Purity
- 98.80%
- Packaging
- 25mg
- Price
- $550
- Updated
- 2021/12/16
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Lexithromycin Chemical Properties,Usage,Production
Description
Lexithromycin is a semisynthetic antibiotic derived from erythromycin . Lexithromycin has improved absorption in vivo over erythromycin due to increased hydrophopicity and pH stability. As with other macrolides, lexithromycin prevents protein synthesis by binding the ribosome at the polypeptide exit tunnel. Formulations containing lexithromycin were tested in clinical trials as treatment for HIV but were discontinued.
Uses
Lexithromycin is an early semi-synthetic erythromycin, prepared by reaction of the 9-keto moiety to methyl oxime. The structural change improves the pH stability profile and hydrophobicity of lexithromycin for better in vivo absorption. This same rationale was used to greater effect with roxithromycin and, as a result, lexithromycin was quickly superseded and has not been not extensively studied. Like all tetracyclines, lexithromycin shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal sub-units, blocking protein synthesis.
Uses
Lexithromycin is a semi-synthetic erythromycin with improved pH stability and hydrophobicity. It is used in compositions and methods for treating viral infections.
References
[1] E HUNT. Erythromycin A 11,12-methylene acetal.[J]. Journal of Antibiotics, 1988, 41 11: 1644-1648. DOI: 10.7164/antibiotics.41.1644
Lexithromycin Preparation Products And Raw materials
Raw materials
Preparation Products
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