aureothricin

Product Name: aureothricin
CAS No.: 574-95-8
Chemical Name: aureothricin
Synonyms: Propionylpyrrothione, Farcinin;5-Methyl-3-propionamidopyrrolin-4-one-[4,3-d]-1,2-dithiole;N-(4,5-Dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)propanamide;N-(4,5-Dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)propionamide;Propanamide, N-(4,5-dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)-;Propionopyrrothine, 5-Methyl-3-propionamidopyrrolin-4-one[4,3-d]-1,2-dithiole
CBNumber: CB41334476
Molecular Formula: C9H10N2O2S2
Formula Weight: 242.32
MOL File: 574-95-8.mol

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aureothricin Property

Melting point:: 260-270℃ (decomposition)
Boiling point:: 479.1±45.0 °C(Predicted)
Density: 1.48±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: soluble; DMSO: soluble; Ethanol: partially soluble; Methanol: partially soluble
pka: 10.54±0.20(Predicted)
form: Yellow to orange solid.
color: Yellow

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Safety

HS Code: 29419090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Precautionary statements: P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19942
Product name: Aureothricin
Purity: ≥98%
Packaging: 500μg
Price: $141
Updated: 2024/03/01

Cayman Chemical

Product number: 19942
Product name: Aureothricin
Purity: ≥98%
Packaging: 1mg
Price: $239
Updated: 2024/03/01

Cayman Chemical

Product number: 19942
Product name: Aureothricin
Purity: ≥98%
Packaging: 5mg
Price: $769
Updated: 2024/03/01

TRC

Product number: A794573
Product name: Aureothricin
Packaging: 1mg
Price: $1000
Updated: 2021/12/16

TRC

Product number: A794573
Product name: Aureothricin
Packaging: 0.5mg
Price: $525
Updated: 2021/12/16

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aureothricin Chemical Properties,Usage,Production

Uses

Aureothricin is an antibiotic first described by Umezawa and co-workers in Japan in 1949. Resurgent interest in this class of microbial metabolites was stimulated by the discovery of their selective antitumour activity. Aureothricin is a more hydrophobic analogue of thiolutin, but has received only limited attention. Members of this class, notably thiolutin, are potent inhibitors of bacterial and yeast RNA polymerases, inhibitors of mannan and glucan formation in fungi, and inhibitors of tumour-cell induced angiogenesis in vivo.

Definition

ChEBI: Aureothricin is a dithiolopyrrolone antibiotic that is 4,5-dihydro[1,2]dithiolo[4,3-b]pyrrole in which the hydrogens at positions 4,5 and 6 have been replaced by methyl, oxo and propanoylamino groups, respectively. It is a moderate antimicrobial by-product of the thiolutin fermentation in various Streptomyces species. It has a role as a bacterial metabolite, an angiogenesis inhibitor, an antibacterial agent and an EC 2.7.7.6 (RNA polymerase) inhibitor. It is a dithiolopyrrolone antibiotic and a secondary carboxamide.

storage

+4°C

aureothricin Preparation Products And Raw materials

Raw materials

Preparation Products

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aureothricin Suppliers

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574-95-8, aureothricinRelated Search:

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N-(4,5-Dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)propanamide

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574-95-8

antibiotic