holomycin

Product Name: holomycin
CAS No.: 488-04-0
Chemical Name: holomycin
Synonyms: holomycin;N-Demethylthiolutin;N-(5-oxo-4H-dithiolo[4,3-b]pyrrol-6-yl)acetamide;N-(4,5-Dihydro-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)acetamide;Acetamide, N-(4,5-dihydro-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)-
CBNumber: CB91367734
Molecular Formula: C7H6N2O2S2
Formula Weight: 214.26
MOL File: 488-04-0.mol

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holomycin Property

Melting point:: 268 °C (decomp)
Boiling point:: 532.1±50.0 °C(Predicted)
Density: 1.63±0.1 g/cm3(Predicted)
solubility: DMSO, Methanol (Heated)
form: Solid
pka: 9.33±0.40(Predicted)
color: Brown-Orange

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Safety

Toxicity: LD50 i.v. in mice: 5-10 mg/kg (Von Daehne)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: H458490
Product name: Holomycin
Packaging: 25mg
Price: $1695
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 46485
Product name: Holomycin
Packaging: 50mg
Price: $2200
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0013069
Product name: HOLOMYCIN
Purity: 95.00%
Packaging: 5MG
Price: $505.7
Updated: 2021/12/16

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holomycin Chemical Properties,Usage,Production

Uses

Holomycin-d3 is the isotope labelled analog of Holomycin (H458490); a member of the pyrrothine class of antibiotics that displays broad-spectrum antibacterial activity.

Definition

ChEBI: Holomycin is a dithiolopyrrolone antibiotic that is 4,5-dihydro[1,2]dithiolo[4,3-b]pyrrole in which the hydrogens at positions 5 and 6 have been replaced by oxo and acetamido groups, respectively. It is an inhibitor of DNA-dependent RNA polymerase, and exhibits antibacterial and antitumour properties. It has a role as a chelator, an antineoplastic agent, an EC 2.7.7.6 (RNA polymerase) inhibitor, an antibacterial agent, a marine metabolite and a bacterial metabolite. It is a dithiolopyrrolone antibiotic and a member of acetamides.

Synthesis Reference(s)

Journal of the American Chemical Society, 86, p. 5654, 1964 DOI: 10.1021/ja01078a049

holomycin Preparation Products And Raw materials

Raw materials

Preparation Products

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holomycin Suppliers

China 8 India 1 United States 2 Global 11

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7892
Advantage: 56

BOC Sciences

Tel: +16314854226
Email: inquiry@bocsci.com
Country: United States
ProdList: 19743
Advantage: 58

Zhejiang Huida Biotech Co., LTD

Tel: 0571-89903882 13626641628
Email: jiangnan@huidabiotech.com
Country: China
ProdList: 3661
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44941
Advantage: 58

Zhejiang Huida Biotech Co., LTD

Tel: 0571-0571-89903882 15990081639
Email: sunshixuan@huidabiotech.com
Country: China
ProdList: 3705
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24023
Advantage: 58

Hangzhou Huiyi Biotechnology Co., LTD

Tel: 0571-89918262 13357170655
Email: chenlingwei@hizyme.com
Country: China
ProdList: 556
Advantage: 58

RD International Technology Co., Limited

Tel: 18024082417
Email: market@ubiochem.com
Country: China
ProdList: 9180
Advantage: 58

488-04-0, holomycinRelated Search:

THIOLUTIN thiomarinol aureothricin holomycin

holomycin

N-(4,5-Dihydro-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)acetamide

N-Demethylthiolutin

N-(5-oxo-4H-dithiolo[4,3-b]pyrrol-6-yl)acetamide

Acetamide, N-(4,5-dihydro-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)-

488-04-0