holomycin
- Product Name
- holomycin
- CAS No.
- 488-04-0
- Chemical Name
- holomycin
- Synonyms
- holomycin;N-Demethylthiolutin;N-(5-oxo-4H-dithiolo[4,3-b]pyrrol-6-yl)acetamide;N-(4,5-Dihydro-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)acetamide;Acetamide, N-(4,5-dihydro-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)-
- CBNumber
- CB91367734
- Molecular Formula
- C7H6N2O2S2
- Formula Weight
- 214.26
- MOL File
- 488-04-0.mol
holomycin Property
- Melting point:
- 268 °C (decomp)
- Boiling point:
- 532.1±50.0 °C(Predicted)
- Density
- 1.63±0.1 g/cm3(Predicted)
- solubility
- DMSO, Methanol (Heated)
- form
- Solid
- pka
- 9.33±0.40(Predicted)
- color
- Brown-Orange
Safety
- Toxicity
- LD50 i.v. in mice: 5-10 mg/kg (Von Daehne)
N-Bromosuccinimide Price
- Product number
- H458490
- Product name
- Holomycin
- Packaging
- 25mg
- Price
- $1695
- Updated
- 2021/12/16
- Product number
- 46485
- Product name
- Holomycin
- Packaging
- 50mg
- Price
- $2200
- Updated
- 2021/12/16
- Product number
- API0013069
- Product name
- HOLOMYCIN
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.7
- Updated
- 2021/12/16
holomycin Chemical Properties,Usage,Production
Uses
Holomycin-d3 is the isotope labelled analog of Holomycin (H458490); a member of the pyrrothine class of antibiotics that displays broad-spectrum antibacterial activity.
Definition
ChEBI: Holomycin is a dithiolopyrrolone antibiotic that is 4,5-dihydro[1,2]dithiolo[4,3-b]pyrrole in which the hydrogens at positions 5 and 6 have been replaced by oxo and acetamido groups, respectively. It is an inhibitor of DNA-dependent RNA polymerase, and exhibits antibacterial and antitumour properties. It has a role as a chelator, an antineoplastic agent, an EC 2.7.7.6 (RNA polymerase) inhibitor, an antibacterial agent, a marine metabolite and a bacterial metabolite. It is a dithiolopyrrolone antibiotic and a member of acetamides.
Synthesis Reference(s)
Journal of the American Chemical Society, 86, p. 5654, 1964 DOI: 10.1021/ja01078a049