PA 824

Product Name: PA 824
CAS No.: 187235-37-6
Chemical Name: PA 824
Synonyms: PRETOMANID;PA 824;CS-930;EOS-60675;Pretomani;(S)-PA 824;PA-824, >=98%;2H4]-Pretomanid;Pretomanid（PA-824）;PA-824(Pretomanid)
CBNumber: CB41348280
Molecular Formula: C14H12F3N3O5
Formula Weight: 359.26
MOL File: 187235-37-6.mol

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PA 824 Property

Melting point:: 149-150℃
Boiling point:: 462.3±55.0 °C(Predicted)
Density: 1.58
storage temp.: -20°C
solubility: DMSO (Slightly), Methanol (Slightly)
pka: -0.67±0.40(Predicted)
form: powder
color: white to brown
optical activity: [α]/D -40 to -48°, c = 1 in methanol

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Safety

HS Code: 2933992000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1290
Product name: PA-824
Purity: ≥98% (HPLC)
Packaging: 10MG
Price: $244
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1290
Product name: PA-824
Purity: ≥98% (HPLC)
Packaging: 50MG
Price: $587.4
Updated: 2024/03/01

TCI Chemical

Product number: P2718
Product name: PA-824
Packaging: 25MG
Price: $270
Updated: 2024/03/01

TCI Chemical

Product number: P2718
Product name: PA-824
Packaging: 100MG
Price: $747
Updated: 2024/03/01

Cayman Chemical

Product number: 13142
Product name: PA-824
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

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PA 824 Chemical Properties,Usage,Production

Uses

A novel anti-tuberculosis drug.

Biological Activity

pa-824, a bicyclic nitroimidazoles, is an anti-tuberculosis (tb) agent that exerts potent in vitro activity against mycobacterium tuberculosis with the minimal inhibition concentration (mic) ranging from 0.015 μg/ml to 0.25 μg/ml and remains actively against a wide range of isolates that are resistant to commonly used anti-tb agents leading to its successful application in the treatment of tb [1].pa-824 has been found to exhibit bactericidal activity against replicating bacilli and non-replicating bacilli under hypoxic or prolonged culture conditions in a dose dependent fashion through two possible mechanisms, which include pa-824 induced inhibition of ketomycolate synthesis and pa-824 mediated donation of nitric oxide during enzymatic nitro-reduction [1].

Biochem/physiol Actions

PA-824 is an anti-tuberculosis drug.

References

[1] ahmad z, peloquin ca, singh rp, derendorf h, tyagi s, ginsberg a, grosset jh, nuermberger el. pa-824 exhibits time-dependent activity in a murine model of tuberculosis. antimicrob agents chemother. 2011 jan;55(1):239-45. doi: 10.1128/aac.00849-10. epub 2010 oct 11.

PA 824 Preparation Products And Raw materials

Raw materials

Preparation Products

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PA 824 Suppliers

Canada 1 China 164 France 1 India 5 Japan 1 United Kingdom 2 United States 19 Global 193

Pharmaffiliates Analytics and Synthetics P. Ltd

Tel: --
Fax: --
Email: mktg@pharmaffiliates.com
Country: India
ProdList: 6739
Advantage: 58

TCI Chemicals (India) Pvt. Ltd.

Tel: --
Fax: --
Email: sales-in@tcichemicals.com
Country: India
ProdList: 6768
Advantage: 58

CHEMSWORTH

Tel: --
Fax: --
Email: info@chemsworth.com
Country: India
ProdList: 6700
Advantage: 30

A.J Chemicals

Tel: --
Fax: --
Email: sales@ajchem.in
Country: India
ProdList: 6100
Advantage: 58

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View Lastest Price from PA 824 manufacturers

Wuhan Circle Star Chem-medical Technology Co.,Ltd

Product: PA 824 187235-37-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98
Supply Ability: 1000
Release date: 2025-01-13

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Product: Pretomanid 187235-37-6
Price: US $0.00/g
Min. Order: 1g
Purity: More Than 99%
Supply Ability: 100kg/Month
Release date: 2024-07-24

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Product: Pretomanid. 187235-37-6
Price: US $0.00/g
Min. Order: 1g
Purity: More Than 99%
Supply Ability: 100kg/Month
Release date: 2025-01-09

187235-37-6, PA 824Related Search:

DEMETON S Sulfanilamide lygtf Sorafenib Gefitinib CZC24832 Ribociclib Erlotinib hydrochloride Olaparib

PA 824

(S)-PA 824

(6S)-6,7-Dihydro-2-nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-5H-imidazo[2,1-b][1,3]oxazine

(S)-6,7-Dihydro-2-nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-5H-imidazo[2,1-b][1,3]oxazine

5H-IMidazo[2,1-b][1,3]oxazine, 6,7-dihydro-2-nitro-6-[[4-(trifluoroMethoxy)phenyl]Methoxy]-, (6S)-

(S)-6-(4-(trifluoromethoxy)benzyloxy)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

(6S)-6,7-Dihydro-2-nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-5H-imidazo[2,1-b][1,3]oxazine PA-824

EOS-60675

2-NITRO-6(S)-[4-(TRIFLUOROMETHOXY)BENZYLOXY]-6,7-DIHYDRO-5H-IMIDAZO[2,1-B][1,3]OXAZINE

PA-824, >=98%

PRETOMANID

(6S)-2-Nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

(S)-2-Nitro-6-((4-(trifluoromethoxy)benzyl)oxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine 98+%

Pretomanid（PA-824）

CS-930

PA-824(Pretomanid)

PA-824;PA824;PA 824

PRETOMANID;(S)-PA 824

(S)-PA 824 (Pretomanid)

(6S)-2-nitro-6-{[4-(trifluoromethoxy)phenyl]metho xy}-5H,6H,7H-imidazo[2,1-b][1,3]oxazine

Pretomanid-D5Q: What is Pretomanid-D5 Q: What is the CAS Number of Pretomanid-D5

187235-37-6 PA 824

2H4]-Pretomanid

Pretomani

187235-37-6

C14H12F3N3O5

Aromatics

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

Inhibitors