Zuranolone

Product Name: Zuranolone
CAS No.: 1632051-40-1
Chemical Name: Zuranolone
Synonyms: Zuranolone;SAGE-217;217;1-[2-[(3R,5R,8R,9R,10S,13S,14S,17S)-3-hydroxy-3,13-dimethyl-2,4,5,6,7,8,9,10,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl]pyrazole-4-carbonitrile;lygtf;CS-2797;Zuranolone, SAGE-217;SAGE-217 (Zuranolone;Zuranolone, 10 mM in DMSO;Zuranolone SAGE-217 CS-2797
CBNumber: CB84033495
Molecular Formula: C25H35N3O2
Formula Weight: 409.57
MOL File: 1632051-40-1.mol

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Zuranolone Property

Boiling point:: 574.3±30.0 °C(Predicted)
Density: 1.32±0.1 g/cm3(Predicted)
solubility: DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:2): 0.33 mg/ml; DMSO: 10 mg/ml
form: A crystalline solid
pka: 15.17±0.60(Predicted)
InChIKey: HARRKNSQXBRBGZ-BOBURQISNA-N
SMILES: C[C@]12CC[C@]3([H])[C@@]4([H])CC[C@](O)(C)C[C@@]4([H])CC[C@@]3([H])[C@]1([H])CC[C@@H]2C(=O)CN1N=CC(C#N)=C1 |&1:1,4,6,10,14,18,20,24,r|

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0023489
Product name: Zuranolone
Purity: 99.96%
Packaging: 2mg
Price: $50
Updated: 2021/12/16

ChemScene

Product number: CS-0023489
Product name: Zuranolone
Purity: 99.96%
Packaging: 5mg
Price: $90
Updated: 2021/12/16

ChemScene

Product number: CS-0023489
Product name: Zuranolone
Purity: 99.96%
Packaging: 10mg
Price: $150
Updated: 2021/12/16

ChemScene

Product number: CS-0023489
Product name: Zuranolone
Purity: 99.96%
Packaging: 25mg
Price: $320
Updated: 2021/12/16

ChemScene

Product number: CS-0023489
Product name: Zuranolone
Purity: 99.96%
Packaging: 50mg
Price: $545
Updated: 2021/12/16

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Zuranolone Chemical Properties,Usage,Production

Description

Zuranolone capsules are used for the treatment postpartum depression (PPD), it is a rapid-acting, once-daily capsule taken for 14 days. Zuranolone works quickly to improve depression symptoms, starting in 3 days compared to current treatment options, which may take weeks or months to work. Zuranolone is the first oral medication to be approved by the FDA to treat postpartum depression.

Uses

Zuranolone is a potent GABAA receptor agonist.

Definition

Zuranolone is a neuroactive steroid gamma-aminobutyric acid (GABA) A receptor-positive modulator, and the first oral medication indicated to treat postpartum depression in adults 2.

Mechanism of action

The mechanism of action of zuranolone in treating PPD is not fully understood but is thought to be related to its positive allosteric modulation of GABAA receptors. Unlike benzodiazepines, another class of GABAA positive modulators, zuranolone binds to the α/β subunit interface presented in all GABAA receptors instead of the α/γ subunit interface. Therefore, zuranolone can bind to both synaptic GABAA receptors, composed of 2α2βγ subunits, and extrasynaptic GABAA receptors, composed of 2α2βδ subunits.

Zuranolone Preparation Products And Raw materials

Raw materials

Preparation Products

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Zuranolone Suppliers

China 97 India 1 United States 4 Global 102

Shanghai Synchem Pharma Co., ltd

Tel: 21-619849051-1 18521059765
Email: synchempharma@aliyun.com
Country: China
ProdList: 6468
Advantage: 55

Nantong Hanfang Biotechnology Co. , Ltd.

Tel: hanfangpharma@126.com; 18616537568
Email: hanfangpharma@126.com
Country: China
ProdList: 29965
Advantage: 58

DELIGHTSEN

Tel: 17695819959
Email: 2567267341@qq.com
Country: China
ProdList: 117
Advantage: 58

Shanghai Hope Chem Co., Ltd.，

Tel: +21-18501659228 18501659228
Fax: sales@hope-chem.com
Email: info@hope-chem.com
Country: China
ProdList: 474
Advantage: 55

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4768
Advantage: 55

Suzhou PengXu PharmaTech Co., Ltd.

Tel: 15850786624
Email: sales@cqpharm.com
Country: China
ProdList: 88
Advantage: 58

Shanghai Shanyuan pharmaceutical technology co., LTD

Tel: 021-31761238 13167072949
Fax: 021-31761238
Email: 3146446224@qq.com
Country: China
ProdList: 1379
Advantage: 55

Cangzhou Enke Pharma-tech Co., Ltd.

Tel: 0317-5296180 15533709196
Fax: 0317-5106596
Email: sale@enkepharma.com
Country: China
ProdList: 2267
Advantage: 55

Shanghai Rechem science Co., Ltd.

Tel: 021-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2991
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

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View Lastest Price from Zuranolone manufacturers

Xi an Biohorlden Industry Trade Co Ltd

Product: Zuranolone 1632051-40-1
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1 kg
Release date: 2025-05-09

Xi an Biohorlden Industry Trade Co Ltd

Product: Zuranolone 1632051-40-1
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1 kg
Release date: 2025-04-27

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Product: Zuranolone 1632051-40-1
Price: US $0.00/g
Min. Order: 1g
Purity: More Than 99%
Supply Ability: 100kg/Month
Release date: 2024-07-24

1632051-40-1, ZuranoloneRelated Search:

Pretomanid

lygtf

SAGE-217

217

SAGE-217; SAGE 217; SAGE217;1632051-40-1

CS-2797

Zuranolone

1-[2-[(3R,5R,8R,9R,10S,13S,14S,17S)-3-hydroxy-3,13-dimethyl-2,4,5,6,7,8,9,10,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl]pyrazole-4-carbonitrile

1H-Pyrazole-4-carbonitrile, 1-[(3α,5β)-3-hydroxy-3-methyl-20-oxo-19-norpregnan-21-yl]-

Inhibitor,inhibit,γ-Aminobutyric acid Receptor,Gamma-aminobutyric acid Receptor,GABA Receptor,Zuranolone

Zuranolone, SAGE-217

1-(2-((3R,5R,8R,9R,10S,13S,14S,17S)-3-Hydroxy-3,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl)-1H-pyrazole-4-carbonitrile

Zuranolone SAGE-217 CS-2797

Zuranolone, 10 mM in DMSO

SAGE-217 (Zuranolone

1632051-40-1