diperdipine

Product Name: diperdipine
CAS No.: 108852-42-2
Chemical Name: diperdipine
Synonyms: YS-201;diperdipine;YS201,YS 201;3-Ethyl 5-(2-(piperidin-1-yl)ethyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;3-Ethyl 5-(2-(piperidin-1-yl)ethyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate , YS-201;3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-ethyl 5-[2-(1-piperidinyl)ethyl] ester
CBNumber: CB41354270
Molecular Formula: C24H31N3O6
Formula Weight: 457.52
MOL File: 108852-42-2.mol

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diperdipine Property

Boiling point:: 593.9±50.0 °C(Predicted)
Density: 1?+-.0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Solid
pka: 8.29±0.10(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-7174
Product name: YS-201
Purity: >99.0%
Packaging: 1mg
Price: $240
Updated: 2021/12/16

ChemScene

Product number: CS-7174
Product name: YS-201
Purity: >99.0%
Packaging: 5mg
Price: $480
Updated: 2021/12/16

ChemScene

Product number: CS-7174
Product name: YS-201
Purity: >99.0%
Packaging: 10mg
Price: $816
Updated: 2021/12/16

ChemScene

Product number: CS-7174
Product name: YS-201
Purity: >99.0%
Packaging: 20mg
Price: $1440
Updated: 2021/12/16

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diperdipine Chemical Properties,Usage,Production

Uses

YS-201 is a dihydropyridine-type calcium channel antagonist. YS-201 has the potential for angina pectoris and hypertension treatment.

in vivo

YS-201 (Diperdipine) markedly reduces systemic vascular resistance and improves stroke index and left ventricular ejection fraction. Mean pulmonary artery and wedge pressures are slightly increased as a possible consequence of enhanced venous return, whereas right atrial and left ventricular end-diastolic pressures are not significantly changed. Nevertheless, an increase in preload is clearly indicated by an augmented left ventricular end-diastolic volume index after administration of diperdipine^[1]. After intravenous and oral doses, absolute bioavailability is calculated to be 18.7%. Biliaryexcretion accounts for about 0.1% of the total clearance of diperdipine and does not contribute to the overall elimination of the drug. After intraportal administration, the bioavailable fraction of diperdipine is increasing up to 44.3% suggesting a prehepatic site of loss of the drug^[2]. The single application of diperdipine to mice and rats by gavage causes intolerance reactions starting at the lowest tested dose level of 200 mg/kg b.w. p.o. (mice) and at 250 mg/kg b.w. p.o. (rats). In the rat, toxic effects occur from 15 mg diperdipine/kg b.w./day p.o. onwards^[3].

References

[1] Di Donato M, et al. Acute hemodynamic effects of intravenous diperdipine, a new dihydropyridine derivative, in coronary heart disease. Am Heart J. 1991 Mar;121(3 Pt 1):776-81. DOI:10.1016/0002-8703(91)90188-n
[2] Greiner PO, et al. Evaluation of first pass effect and biliary excretion of diperdipine in the dog. Eur J Drug Metab Pharmacokinet. 1990 Jul-Sep;15(3):185-90. DOI:10.1007/BF03190202
[3] Herzog R, et al. Experimental studies on the toxicity of diperdipine following oral and parenteral application. Arzneimittelforschung. 1995 Mar;45(3):240-5. PMID:7741776

diperdipine Preparation Products And Raw materials

Raw materials

Preparation Products

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diperdipine Suppliers

China 10 United States 4 USA 1 Global 15

MedChemexpress LLC

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Biosynth Biological Technology (Suzhou) Co Ltd

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108852-42-2, diperdipineRelated Search:

YS121 YS-035 HYDROCHLORIDE YS 49

diperdipine

YS-201

3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-ethyl 5-[2-(1-piperidinyl)ethyl] ester

YS201,YS 201

3-Ethyl 5-(2-(piperidin-1-yl)ethyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

3-Ethyl 5-(2-(piperidin-1-yl)ethyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate , YS-201

108852-42-2