ChemicalBook > CAS DataBase List > AMYLOID BETA-PROTEIN (HUMAN, 1-40) TRIFLUOROACETATE

AMYLOID BETA-PROTEIN (HUMAN, 1-40) TRIFLUOROACETATE

Product Name
AMYLOID BETA-PROTEIN (HUMAN, 1-40) TRIFLUOROACETATE
CAS No.
131438-79-4
Chemical Name
AMYLOID BETA-PROTEIN (HUMAN, 1-40) TRIFLUOROACETATE
Synonyms
aβ40;Ab40;Aβ40;DV-40;Abeta40;Amyloid b-Peptide (1;b-AMyloid (1-40), rat;2-Amyloid(1-40) Human;SS-AMYLOID (1-40), RAT;β-Amyloid (1-40),human
CBNumber
CB4136891
Molecular Formula
C194H295N53O58S
Formula Weight
4329.8034
MOL File
131438-79-4.mol
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AMYLOID BETA-PROTEIN (HUMAN, 1-40) TRIFLUOROACETATE Property

storage temp. 
-20°C
solubility 
H2O: ~6 mg/mL
form 
powder
color 
white
Water Solubility 
Soluble to 1 mg/ml in water
Sequence
H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH
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Safety

WGK Germany 
3
HS Code 
3504009000
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A1075
Product name
Amyloid β Protein Fragment 1-40
Purity
≥90% (HPLC), powder
Packaging
0.1mg
Price
$209
Updated
2024/03/01
Sigma-Aldrich
Product number
A1075
Product name
Amyloid β Protein Fragment 1-40
Purity
≥90% (HPLC), powder
Packaging
0.5mg
Price
$707
Updated
2024/03/01
Cayman Chemical
Product number
21617
Product name
Amyloid-β (1-40) Peptide (human)
Purity
≥95%
Packaging
1mg
Price
$205
Updated
2021/12/16
Cayman Chemical
Product number
21617
Product name
Amyloid-β (1-40) Peptide (human)
Purity
≥95%
Packaging
500μg
Price
$108
Updated
2021/12/16
Usbiological
Product number
353611
Product name
Abeta40
Packaging
48Tests
Price
$588
Updated
2021/12/16
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AMYLOID BETA-PROTEIN (HUMAN, 1-40) TRIFLUOROACETATE Chemical Properties,Usage,Production

Uses

Amyloid β-protein is neurotrophic and neurotoxic in vivo and in vitro in human and rat neuronal cell cultures. β-Amyloid peptides (amino acids 1-42 and 1-43) are the major constituents of senile plaques and neurofibrillary tangles that occur in the hippoc

Uses

Amyloid β Protein Fragment 1-40 has been used:

  • in the temperature based conformational studies using Fourier transform infrared/differential scanning calorimetry (FT-IR/DSC) studies
  • as a reference standard in sandwich-type enzyme immunoassay for quantifying amyloid A4 protein in cerebrospinal fluid of patients with head trauma
  • as a component of embryonic stem cell medium to inhibit amyloid deposition in fibroblasts

Definition

ChEBI: Amyloid-beta polypeptide 40 is a beta-amyloid that is a 40 amino acid polypeptide of sequence Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile Gly Leu Met Val Gly Gly Val Val.

General Description

Amyloid β Protein Fragment 1-40 (Aβ40) is derived from the amyloid-β protein (Aβ), which is mapped to human chromosome 21q21.3. Aβ40 is predominantly present in the vascular amyloid deposits. Aβ40 comprises of C-terminal membrane insertion domain. It shows structural transition from random coil to a α-helical structure in a water-micelle medium.

Biological Activity

amyloid β-peptide (1-40) (human), (c194h295n53o58s1), a peptide with the sequence h2n-daefrhdsgyevhhqklvffaedvgsnkgaiiglmvggvvia-oh, mw= 4329.8. amyloid beta (aβ or abeta) is a peptide of 36-43 amino acids that is processed from the amyloid precursor protein. while best known as a component of amyloid plaques in association with alzheimer's disease, evidence has been found that aβ is a highly multifunctional peptide with significant non-pathological activity(1). aβ is the main component of deposits found in the brains of patients with alzheimer's disease. brain aβ is elevated in patients with sporadic alzheimer’s disease. aβ is the main constituent of brain parenchymal and vascular amyloid, it contributes to cerebrovascular lesions and is neurotoxic(2). aβ protein is generated by successive action of the β and γ secretases. the γ secretase, which produces the c-terminal end of the aβ peptide, cleaves within the transmembrane region of app and can generate a number of isoforms of 36-43 amino acid residues in length. the most common isoforms are aβ40 and aβ42; the longer form is typically produced by cleavage that occurs in the endoplasmic reticulum, while the shorter form is produced by cleavage in the trans-golgi network(3).figure1 structure of amyloid β-peptide (1-40) (human)

Biochem/physiol Actions

Amyloid β-protein is neurotrophic and neurotoxic in vivo and in vitro in human and rat neuronal cell cultures. β-Amyloid peptides (amino acids 1-42 and 1-43) are the major constituents of senile plaques and neurofibrillary tangles that occur in the hippocampus, neocortex, and amygdala of patients with Alzheimer′s disease.

storage

-20°C

References

1. Lahiri DK, Maloney B (September 2010). "Beyond the signaling effect role of amyloid–β42 on the processing of AβPP, and its clinical implications". Exp. Neurol. 225 (1): 51-4.2. Hardy J, Duff K, Hardy KG, Perez-Tur J, Hutton M (September 1998). "Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau". Nat. Neurosci. 1 (5): 355-8.3. Hartmann T, Bieger SC, Brühl B, Tienari PJ, Ida N, Allsop D, Roberts GW, Masters CL, Dotti CG, Unsicker K, Beyreuther K (September 1997). "Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides". Nat. Med. 3 (9): 1016-20.

AMYLOID BETA-PROTEIN (HUMAN, 1-40) TRIFLUOROACETATE Preparation Products And Raw materials

Raw materials

Preparation Products

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AMYLOID BETA-PROTEIN (HUMAN, 1-40) TRIFLUOROACETATE Suppliers

China 110 Europe 1 Germany 5 Switzerland 1 United Kingdom 4 United States 16 USA 1 Global 138
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View Lastest Price from AMYLOID BETA-PROTEIN (HUMAN, 1-40) TRIFLUOROACETATE manufacturers

Hebei Mojin Biotechnology Co., Ltd
Product
AMYLOID BETA-PROTEIN (HUMAN, 1-40) TRIFLUOROACETATE 131438-79-4
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-09-28
Career Henan Chemical Co
Product
AMYLOID BETA-PROTEIN (HUMAN, 1-40) TRIFLUOROACETATE 131438-79-4
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
25kg
Release date
2019-07-12
GenicBio Limited
Product
Beta-Amyloid 1-40 131438-79-4
Price
US $1.00/MG
Min. Order
1MG
Purity
>95% HPLC
Supply Ability
1mg,5mg,10mg,25mg,100mg,1g,10g
Release date
2018-06-11

131438-79-4, AMYLOID BETA-PROTEIN (HUMAN, 1-40) TRIFLUOROACETATERelated Search:

β-Amyloid (18-28) β- Amyloid (1-34) β- Amyloid (4-10) β-Amyloid (1-20) β-Amyloid (10-35), amide β-Amyloid (12-20) β- Amyloid (11-22) β-Amyloid (1-9) β-Amyloid (15-21) β-Amyloid (1-42), rat TFA β-Amyloid (22-40) β-Amyloid (1-17) TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) Tris(2,4-pentanedionato)chroMiuM(III) Ferric acetylacetonate Cupric acetylacetonate METHYL ISOCYANOACETATE DICHLORO(ETHYLENEDIAMINE)PLATINUM(II)

  • AMYLOID B-PROTEIN FRAGMENT 1-40
  • Amyloidb-Peptide(1-40)(human)
  • H-Asp-Ala-Glu-Phe-Gly-His-Asp-Ser-Gly-Phe-Glu-Val-Arg-His-Asp-Ser-Gly-Phe-Glu-Val-Arg-His-Gln-Lys-Leu-Val-Gly-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH
  • Amyloid beta Protein fragment 1-40 HCl Salt
  • amyloid β protein fragment 1-40
  • aβ40
  • SS-AMYLOID (1-40), RAT
  • M.W. 4329.86 C194H295N53O58S
  • ASP-ALA-GLU-PHE-GLY-HIS-ASP-SER-GLY-PHE-GLU-VAL-ARG-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-GLY-ALA-ILE-ILE-GLY-LEU-MET-VAL-GLY-GLY-VAL-VAL
  • beta Amyloid (1-40) human
  • H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH
  • REF DUPL: H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH
  • Amyloid β-Peptide (1-40) (human)
  • Amyloid β Protein Fragment 1-40,Aβ40
  • b-AMyloid (1-40), rat
  • AMyloid b-Protein (1-40)
  • Abeta40
  • Amyloid beta peptide(1-40) (synthetic)
  • beta-Amyloid peptide(1-40)
  • beta-Amyloid protein(1-40)
  • Human beta-amyloid peptide-(1-40)
  • Amyloid β-Protein (1-40) (HFIP-treated)
  • 2-Amyloid(1-40) Human
  • Amyloid- (1-40) Peptide (human)
  • Amyloid β-Protein (1-40) hydrochloride salt
  • Ab40
  • Amyloid beta-Protein (1-40) hydrochloride salt H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH hydrochloride salt
  • Amyloid beta-Protein (1-40) trifluoroacetate salt H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH trifluoroacetate salt
  • Amyloid β Protein Fragment 1-40, ≥95%(HPLC),powder
  • Amyloid beta-Protein (Human, 1-40)
  • AMyloid β-Protein (1-40)
  • Amyloid beta Protein Fragment 1-40 >=90% (HPLC), powder
  • β-Amyloid (1-40), Ultra Pure, TFA
  • DV-40
  • AMYLOID BETA-PROTEIN (HUMAN, 1-40) TRIFLUOROACETATE USP/EP/BP
  • Amyloid b-Peptide (1
  • Aβ40
  • Amyloid β Protein Fragment 1-40
  • Amyloid β-Peptide (1-40) (human)
  • β-Amyloid (1-40),human
  • DAEFGHDSGFEVRHDSGFEVRHQKLVGFFAEDVGSNKGAIIGLMVGGVV
  • 131438-79-4
  • C190H291N51O57S
  • proteins
  • Peptide
  • Amyloid beta-peptide and related
  • Neuroscience