ChemicalBook > CAS DataBase List > 2-FLUORO-3-HYDROXYPHENYLBORONIC ACID

2-FLUORO-3-HYDROXYPHENYLBORONIC ACID

Product Name
2-FLUORO-3-HYDROXYPHENYLBORONIC ACID
CAS No.
855230-60-3
Chemical Name
2-FLUORO-3-HYDROXYPHENYLBORONIC ACID
Synonyms
(2-Fluoro-3-hydroxyphenyl);2-FLUORO-3-HYDROXYPHENYLBORONIC ACID;2-Fluoro-3-hydroxybenzeneboronic acid;2-Fluoro-3-hydroxybenzeneboronicacid96%;2-Fluoro-3-hydroxybenzeneboronic acid 96%;Boronic acid, B-(2-fluoro-3-hydroxyphenyl)-;(2-Fluoro-3-hydroxyphenyl)boronic acid(contains varying amounts of Anhydride)
CBNumber
CB4137409
Molecular Formula
C6H6BFO3
Formula Weight
155.92
MOL File
855230-60-3.mol
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2-FLUORO-3-HYDROXYPHENYLBORONIC ACID Property

storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
solid
color 
pink
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Safety

HS Code 
2931900090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

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N-Bromosuccinimide Price

TRC
Product number
F595323
Product name
2-Fluoro-3-hydroxyphenylboronicacid
Packaging
25mg
Price
$45
Updated
2021/12/16
TRC
Product number
F595323
Product name
2-Fluoro-3-hydroxyphenylboronicacid
Packaging
250mg
Price
$130
Updated
2021/12/16
ChemScene
Product number
CS-B1249
Product name
2-Fluoro-3-hydroxyphenylboronicacid
Purity
99.85%
Packaging
1g
Price
$50
Updated
2021/12/16
AK Scientific
Product number
J98138
Product name
2-Fluoro-3-hydroxyphenylboronicacid
Packaging
1g
Price
$75
Updated
2021/12/16
ChemScene
Product number
CS-B1249
Product name
2-Fluoro-3-hydroxyphenylboronicacid
Purity
99.85%
Packaging
5g
Price
$147
Updated
2021/12/16
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2-FLUORO-3-HYDROXYPHENYLBORONIC ACID Chemical Properties,Usage,Production

Synthesis

352303-67-4

855230-60-3

General procedure for the synthesis of 2-fluoro-3-hydroxyphenylboronic acid from 2-fluoro-3-methoxyphenylboronic acid: 2-fluoro-3-methoxyphenylboronic acid (1.1 g, 6.5 mmol) was dissolved in 30 mL of dichloromethane and cooled to 5 °C under nitrogen protection. Under stirring conditions, 32 mL of a dichloromethane solution of boron tribromide (1 M, 32 mmol) was slowly added dropwise. After the dropwise addition, the reaction mixture was stirred at room temperature for 1 hour. Subsequently, the reaction mixture was slowly added dropwise to 50 mL of pre-cooled ethanol. An excess of solid sodium bicarbonate was added in batches to neutralize the reaction mixture under cooled conditions. After completion of neutralization, stirring was continued for 15 minutes, followed by filtration and the filtrate was evaporated and concentrated. The residue was dissolved in tetrahydrofuran, filtered again and the solvent evaporated to give 0.96 g (96% yield) of 2-fluoro-3-hydroxyphenylboronic acid. The product was characterized by 1H NMR (200 MHz, DMSO-d6): δ 9.53 (1H, s), 8.13 (2H, m), 6.91 (3H, m).

References

[1] Patent: EP2196465, 2010, A1. Location in patent: Page/Page column 30; 31
[2] Journal of Medicinal Chemistry, 2016, vol. 59, # 23, p. 10479 - 10497
[3] Patent: WO2006/5918, 2006, A1. Location in patent: Page/Page column 89

2-FLUORO-3-HYDROXYPHENYLBORONIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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2-FLUORO-3-HYDROXYPHENYLBORONIC ACID Suppliers

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855230-60-3, 2-FLUORO-3-HYDROXYPHENYLBORONIC ACIDRelated Search:

2,6-DIFLUORO-3-(2'-FLUOROBENZYLOXY)PHEN& 2,6-Difluoro-3-methoxybenzeneboronic acid 2,6-Difluoro-3-ethoxybenzeneboronic acid 3-Methoxy-2,4,6-trifluorophenylboronic acid 2,6-DIFLUORO-3-(3',5'-DIMETHOXYBENZYLOX& 2,6-DIFLUORO-3-ISOPROPOXYPHENYLBORONIC & 3-ETHOXY-2,4,6-TRIFLUOROPHENYLBORONIC A& 3-BUTOXY-2,4,6-TRIFLUOROPHENYLBORONIC A& 3-BUTOXY-2,6-DIFLUOROPHENYLBORONIC ACID 3-(Benzyloxy)-2,6-difluorobenzeneboronic acid 3-ISOPROPOXY-2,4,6-TRIFLUOROBENZENEBORONIC ACID 2,6-DIFLUORO-3-PROPOXYPHENYLBORONIC ACID 2,6-DIFLUORO-3-(2'-CHLOROBENZYLOXY)PHEN& 2-FLUORO-3-METHOXYPHENYLBORONIC ACID 3-ETHOXY-2-FLUOROPHENYLBORONIC ACID 3-Hydroxyphenylboronic acid 6-BROMO-3-BUTOXY-2-FLUOROPHENYLBORONIC ACID 2-(6-BROMO-2-FLUORO-3-METHOXYPHENYL)-1,3,2-DIOXABOROLANE

  • 2-FLUORO-3-HYDROXYPHENYLBORONIC ACID
  • 2-Fluoro-3-hydroxybenzeneboronicacid96%
  • 2-Fluoro-3-hydroxybenzeneboronic acid 96%
  • 2-Fluoro-3-hydroxybenzeneboronic acid
  • (2-Fluoro-3-hydroxyphenyl)
  • Boronic acid, B-(2-fluoro-3-hydroxyphenyl)-
  • (2-Fluoro-3-hydroxyphenyl)boronic acid(contains varying amounts of Anhydride)
  • 855230-60-3