Pentosan Sulfuric Polyester
- Product Name
- Pentosan Sulfuric Polyester
- CAS No.
- 37300-21-3
- Chemical Name
- Pentosan Sulfuric Polyester
- Synonyms
- Xylofuranan sulfate;PENTOSAN POLYSULFATE SOD;Pentosan Sulfuric Polyester;[(2R,3R,4S,5R)-2-hydroxy-5-[(2S,3R,4S,5R)-5-hydroxy-3,4-disulfooxyoxan-2-yl]oxy-3-sulfooxyoxan-4-yl] hydrogen sulfate;[(2R,3R,4S,5R)-2-hydroxy-5-[(2S,3R,4S,5R)-5-hydroxy-3,4-disulfooxy-oxan-2-yl]oxy-3-sulfooxy-oxan-4-yl] hydrogen sulfate;sulfuric acid [(2R,3R,4S,5R)-2-hydroxy-5-[(2S,3R,4S,5R)-5-hydroxy-3,4-disulfoxy-tetrahydropyran-2-yl]oxy-3-sulfoxy-tetrahydropyran-4-yl] ester
- CBNumber
- CB41397804
- Molecular Formula
- C10H18O21S4
- Formula Weight
- 0
- MOL File
- Mol file
Pentosan Sulfuric Polyester Property
- form
- Solid
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- CS-7813
- Product name
- PentosanPolysulfate
- Packaging
- 100mg
- Price
- $84
- Updated
- 2021/12/16
- Product number
- API0009982
- Product name
- PENTOSAN POLYSULFATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $501.57
- Updated
- 2021/12/16
Pentosan Sulfuric Polyester Chemical Properties,Usage,Production
Definition
ChEBI: [(2R,3R,4S,5R)-2-Hydroxy-5-{[(2S,3R,4S,5R)-5-hydroxy-3,4-bis(sulfooxy)oxan-2-yl]oxy}-4-(sulfooxy)oxan-3-yl]oxidanesulfonic acid is a glycoside.
Biological Activity
Pentosan Polysulfate is an orally bioavailable semi-synthetic drug with anti-inflammatory and pro-chondrogenesis properties. Pentosan Polysulfate is also a potent and selective anti-HIV drug. Pentosan Polysulfate Sodium for the study of interstitial cystitis.
in vitro
Pentosan polysulfate has been shown to inhibit HIV-1 activity with an ED 50 of 0.19 μg/mL in MT-4 cells. It inhibits HIV-1 antigen expression in HUT-78 cells at an ED 50 of 0.02 μg/mL, and complete inhibition of HIV-1 antigen expression is obtained at a concentration of 4.0 μg/mL.
Pentosan Polysulfate suppresses NF-κB, decreases the proinflammatory actions of TNFα, and decreases high glucose and advanced glycation end products (AGEs) stimulated MCP-1 production.
in vivo
Pentosan polysulfate has been shown to decrease interstitial inflammation and glomerulosclerosis in 5/6 nephrectomized rats. Pentosan polysulfate treatment preserves renal function, significantly reduces albuminuria, and markedly decreases the severity of renal lesions, including tubulointerstitial inflammation. Pentosan polysulfate also reduces upregulation of TNFα and proinflammatory genes in aging diabetic kidneys.
target
| HIV-1 < span> |
Pentosan Sulfuric Polyester Preparation Products And Raw materials
Raw materials
Preparation Products
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