ChemicalBook > CAS DataBase List > cynaropicrin

cynaropicrin

Product Name: cynaropicrin
CAS No.: 35730-78-0
Chemical Name: cynaropicrin
Synonyms: Cynaropikrin;cynaropicrin;Cynaropicrin-RM;Cynaropicrin(AS);CYNAROPICRIN(SH);Cynaropicrin - Cynara cardunculus (artichoke);(3aR,4S,6aR,8S,9aR,9bR)-8-Hydroxy-3,6,9-trimethylene-2-oxododecahydroazuleno[4,5-b]furan-4-yl 2-(hydroxymethyl)acrylate;2-Hydroxymethylpropenoic acid (3aR,4S,6aβ,9aβ,9bα)-dodecahydro-8α-hydroxy-3,6,9-tris(methylene)-2-oxoazuleno[4,5-b]furan-4-yl ester;2-Propenoic acid, 2-(hydroxymethyl)-, (3aR,4S,6aR,8S,9aR,9bR)-dodecahydro-8-hydroxy-3,6,9-tris(methylene)-2-oxoazuleno[4,5-b]furan-4-yl ester;(3aR,4S,6aR,8S,9aR,9bS)-8-hydroxy-3,6,9-trimethylene-2-oxo-3a,4,5,6a,7,8,9a,9b-octahydroazuleno[4,5-b]furan-4-yl]2-(hydroxymethyl)prop-2-enoate
CBNumber: CB41398432
Molecular Formula: C19H22O6
Formula Weight: 346.37
MOL File: 35730-78-0.mol

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cynaropicrin Property

Boiling point:: 566.2±50.0 °C(Predicted)
Density: 1.28±0.1 g/cm3 (20 ºC 760 Torr)
storage temp.: -20°C, protect from light
solubility: DMSO:50.0(Max Conc. mg/mL);144.35(Max Conc. mM)
pka: 13.52±0.10(Predicted)
form: Oil
color: Off-white to light yellow
biological source: plant
LogP: 1.340 (est)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHL89619
Product name: Cynaropicrin
Purity: phyproof? Reference Substance
Packaging: 10MG
Price: $794
Updated: 2025/07/31

Cayman Chemical

Product number: 25099
Product name: Cynaropicrin
Purity: ≥98%
Packaging: 1mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 25099
Product name: Cynaropicrin
Purity: ≥98%
Packaging: 5mg
Price: $356
Updated: 2024/03/01

TRC

Product number: C993005
Product name: Cynaropicrin
Packaging: 5mg
Price: $290
Updated: 2021/12/16

Usbiological

Product number: 300139
Product name: Cynaropicrin
Packaging: 10mg
Price: $490
Updated: 2021/12/16

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cynaropicrin Chemical Properties,Usage,Production

Uses

Cynaropicrin can inhibit lipopolysaccharide-induced TNF-α release from either murine or human macrophage cells in a dose-dependent manner with the IC50 values of 8.24 and 3.18 μM, respectively. It can also inhibit the increase of cartilage degradation factor (MMP13) and suppresses NF-κB signaling.

Definition

ChEBI: Cynaropicrin is a sesquiterpene lactone.

Biological Activity

Cynaropicrin is a potent activator of the AhR-Nrf2-Nqo1 pathway, making it a potential candidate for preventing UVB-induced photoaging. Additionally, it exhibits pro-apoptotic activity, suggesting its potential as an anticancer agent against certain leukocyte cancer cells such as lymphoma or leukemia. Cynaropicrin has demonstrated in vivo activity against Trypanosoma brucei and exhibits immunomodulatory effects by influencing cytokine release and nitric oxide production while also displaying immunosuppressive properties. Moreover, it has anti-inflammatory effects by inhibiting the production of inflammatory mediators and lymphocyte proliferation, which is achieved through conjugation with sulphydryl groups of target protein(s).

cynaropicrin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from cynaropicrin manufacturers

Career Henan Chemical Co

Product: cynaropicrin 35730-78-0
Price: US $1.00/kg
Min. Order: 1 mg
Purity: 99%
Supply Ability: 100KG
Release date: 2018-12-25

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Cynaropikrin

[(3aR,4S,6aR,8S,9aR,9bR)-8-hydroxy-3,6,9-trimethylidene-2-oxo-3a,4,5,6a,7,8,9a,9b-octahydroazuleno[4,5-b]furan-4-yl] 2-(hydroxymethyl)prop-2-enoate

2-methylolacrylic acid [(3aR,4S,6aR,8S,9aR,9bR)-8-hydroxy-2-keto-3,6,9-trimethylene-3a,4,5,6a,7,8,9a,9b-octahydroazuleno[4,5-b]furan-4-yl] ester

CYNAROPICRIN(SH)

cynaropicrin

Cynaropicrin - Cynara cardunculus (artichoke)

2-Propenoic acid, 2-(hydroxymethyl)-, (3aR,4S,6aR,8S,9aR,9bR)-dodecahydro-8-hydroxy-3,6,9-tris(methylene)-2-oxoazuleno[4,5-b]furan-4-yl ester

(3aR,4S,6aR,8S,9aR,9bS)-8-hydroxy-3,6,9-trimethylene-2-oxo-3a,4,5,6a,7,8,9a,9b-octahydroazuleno[4,5-b]furan-4-yl]2-(hydroxymethyl)prop-2-enoate

Cynaropicrin(AS)

Cynaropicrin-RM

(3aR,4S,6aR,8S,9aR,9bR)-8-Hydroxy-3,6,9-trimethylene-2-oxododecahydroazuleno[4,5-b]furan-4-yl 2-(hydroxymethyl)acrylate

35730-78-0