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Hederagenin 3-O-α-L-rhaMnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside

Product Name
Hederagenin 3-O-α-L-rhaMnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside
CAS No.
68027-15-6
Chemical Name
Hederagenin 3-O-α-L-rhaMnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside
Synonyms
Pulsatilla saponin D, BR;Pulsatilla Saponin D (90%);Pulsatilla saponin D (SB365);Pulsatilla saponin D 68027-15-6;Pulsatilla saponin D, 10 mM in DMSO;Hederagenin 3-O-α-L-rhamnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside;Olean-12-en-28-oic acid,3-[[O-6-deoxy-a-L-mannopyranosyl-(12)-O-[b-D-glucopyranosyl-(14)]-a-L-arabinopyranosyl]oxy]-23-hydroxy-, (3b,4a)-;Olean-12-en-28-oic acid, 3-[[O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→4)]-α-L-arabinopyranosyl]oxy]-23-hydroxy-, (3β,4α)-
CBNumber
CB82645784
Molecular Formula
C47H76O17
Formula Weight
913.09614
MOL File
68027-15-6.mol
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Hederagenin 3-O-α-L-rhaMnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside Property

Melting point:
239-241℃
Boiling point:
997.6±65.0 °C(Predicted)
Density 
1.40±0.1 g/cm3 (20 ºC 760 Torr)
storage temp. 
Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility 
Methanol (Slightly), Pyridine
pka
4.63±0.70(Predicted)
form 
Solid
color 
White to Light Beige
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
29455
Product name
Pulsatilla Saponin D
Packaging
1mg
Price
$49
Updated
2024/03/01
Cayman Chemical
Product number
29455
Product name
Pulsatilla Saponin D
Packaging
5mg
Price
$156
Updated
2024/03/01
TRC
Product number
P165920
Product name
PulsatillaSaponinD(90%)
Packaging
5mg
Price
$90
Updated
2021/12/16
AK Scientific
Product number
2878AH
Product name
(4AS,6AS,6BR,8AR,9R,10S,12AR,12BR,14BS)-10-(((2S,3R,4S,5S)-4-Hydroxy-5-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-9-(hydroxymethyl)-2,2,6A,6B,9,12A-hexamethyl-1,2,3,4,4A,5,6,6A,6B,7,8,8A,9,10,11,12,12A,12B,13,14B-icosahydropicene-4A-carboxylicacid
Packaging
1mg
Price
$179
Updated
2021/12/16
ApexBio Technology
Product number
N2045
Product name
PulsatillasaponinD
Packaging
5mg
Price
$208
Updated
2021/12/16
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Hederagenin 3-O-α-L-rhaMnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside Chemical Properties,Usage,Production

Description

Pulsatilla saponin D is an oleanane-type saponin that has been found in P. koreana and has anticancer activity. It is cytotoxic to A549, SKOV3, SK-MEL-2, and HCT15 cells (EC50s = 11.25, 13.17, 3.04, and 11.86 μM, respectively). Pulsatilla saponin D (6 mg/kg per day) reduces tumor volume in a murine Lewis lung carcinoma model.

Chemical Properties

White powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Pulsatilla chinensis.

Uses

Pulsatilla Saponin D shows antiangiogenic and antitumor activity.

Definition

ChEBI: Pulsatilla saponin D is a triterpenoid. It has a role as a metabolite.

in vivo

Pulsatilla saponin D (6.4 mg/kg) exhibits anti-tumor activity in Lewis lung carcinoma model[4].

Animal Model:2x2x2 mm3 tumor fragments of a Lewis lung carcinoma (LLC) transplanted s.c. into the auxiliary region of the BDF1 mice[4].
Dosage:6.4 mg/kg.
Administration:Intraperitoneally on the 1 st to 7 th and 9 th to 14 th day.
Result:Had such a potent antitumor effect (IR, 82 %) on a solid tumor, which is higher than Adriamycin (IR, 64%).

References

[1] SEONG-CHEOL BANG. Antitumor activity of Pulsatilla koreana saponins and their structure-activity relationship.[J]. Chemical & pharmaceutical bulletin, 2005, 53 11: 1451-1454. DOI: 10.1248/cpb.53.1451

Hederagenin 3-O-α-L-rhaMnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside Preparation Products And Raw materials

Raw materials

Preparation Products

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Hederagenin 3-O-α-L-rhaMnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside Suppliers

China 107 India 1 United States 14 Global 122
Nanjing Chemlin Chemical Co., Ltd
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025-83697070
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info@chemlin.com.cn
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China
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Chengdu Biopurify Phytochemicals Ltd.
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+86-028-82633397 18982077548
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cwb1@biopurify.cn
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Nanjing Spring & Autumn Biological Engineering Co., Ltd.
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025-84430028 13815430202
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China
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Haoyuan Chemexpress Co., Ltd.
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(86) 21-58955996
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MedChemexpress LLC
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Shanghai Tauto Biotech Co., Ltd.
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Cheng Du Pufeide Biotechnology Co., Ltd.
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Chengdu Herbpurify Co.Ltd.
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ChemStrong Scientific Co.,Ltd
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Wuxi Zhongkun Biochemical Technology Co., Ltd.
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View Lastest Price from Hederagenin 3-O-α-L-rhaMnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside manufacturers

Shaanxi Haibo Biotechnology Co., Ltd
Product
Pulsatilla saponin D 68027-15-6
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
2000ton
Release date
2023-08-21
Shanghai Standard Technology Co., Ltd.
Product
Pulsatilla saponin D 68027-15-6
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2020-03-05
NanJing Spring & Autumn Biological Engineering CO., LTD.
Product
Pulsatilla saponin D 68027-15-6 68027-15-6
Price
US $650.00/g
Min. Order
10mg
Purity
≥98% HPLC
Supply Ability
1000.00 kgs
Release date
2019-06-27

68027-15-6, Hederagenin 3-O-α-L-rhaMnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranosideRelated Search:

N-ACETYLLACTOSAMINE V Hederacolchiside E V Scabioside C Hederacolchiside A1 PULCHINENOSIDE B4 Lup-20(29)-en-28-oic acid, 3-[β-D-glucopyranosyl(1→4)[a-L-rhaMnopyranosyl) (1→2)-a -L-arabinopyranosyl]oxy], (3β,4a)-) Pulchinenoside B Anemoside A3 Pulchinenoside A3

  • Pulsatilla saponin D (SB365)
  • Pulsatilla Saponin D (90%)
  • Olean-12-en-28-oic acid,3-[[O-6-deoxy-a-L-mannopyranosyl-(12)-O-[b-D-glucopyranosyl-(14)]-a-L-arabinopyranosyl]oxy]-23-hydroxy-, (3b,4a)-
  • Pulsatilla saponin D 68027-15-6
  • Pulsatilla saponin D, BR
  • Olean-12-en-28-oic acid, 3-[[O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→4)]-α-L-arabinopyranosyl]oxy]-23-hydroxy-, (3β,4α)-
  • Hederagenin 3-O-α-L-rhamnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside
  • Pulsatilla saponin D, 10 mM in DMSO
  • 68027-15-6
  • reagent
  • standard substance
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract