ChemicalBook > CAS DataBase List > 2,5-Dihydroxy-1,4-dithiane

2,5-Dihydroxy-1,4-dithiane

Product Name
2,5-Dihydroxy-1,4-dithiane
CAS No.
40018-26-6
Chemical Name
2,5-Dihydroxy-1,4-dithiane
Synonyms
1,4-DITHIANE-2,5-DIOL;DITHIANE;p-Dithiane-2,5-diol;FEMA 3826;1,4-Dithiane-2,5-dio;1,4-dithane-2,5-diol;MERCATOACETALDEHYDE DIMER;DHDT;NSC 106280;4-dithiane
CBNumber
CB4141273
Molecular Formula
C4H8O2S2
Formula Weight
152.24
MOL File
40018-26-6.mol
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2,5-Dihydroxy-1,4-dithiane Property

Melting point:
130 °C (dec.) (lit.)
Boiling point:
244.73°C (rough estimate)
Density 
1.224 (estimate)
vapor pressure 
0Pa at 25℃
refractive index 
1.5200 (estimate)
FEMA 
3826 | 2,5-DIHYDROXY-1,4-DITHIANE
storage temp. 
2-8°C
solubility 
H2O: 0.39% at 20 °C
form 
Crystalline Powder
pka
12.04±0.40(Predicted)
color 
White to yellow
PH
4.9 (3.9g/l, H2O)
Odor
at 0.10 % in propylene glycol. sulfury meaty toasted bread broth egg tomato
Odor Type
sulfurous
biological source
synthetic
Water Solubility 
3.9 g/L (20 ºC)
JECFA Number
550
BRN 
104402
InChIKey
YUIOPHXTILULQC-UHFFFAOYSA-N
LogP
-0.276 at 22.8℃ and pH6.3
CAS DataBase Reference
40018-26-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-41-43-52/53-36/37/38
Safety Statements 
26-36/37/39-61-37/39-24-36
RIDADR 
UN2811
WGK Germany 
2
F 
1-8-10-13
HazardClass 
6.1
PackingGroup 
III
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H317May cause an allergic skin reaction

H330Fatal if inhaled

H373May cause damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P314Get medical advice/attention if you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
183954
Product name
1,4-Dithiane-2,5-diol
Purity
97%
Packaging
50g
Price
$52.5
Updated
2023/01/07
Sigma-Aldrich
Product number
183954
Product name
1,4-Dithiane-2,5-diol
Purity
97%
Packaging
250g
Price
$115
Updated
2023/01/07
TCI Chemical
Product number
D1761
Product name
2,5-Dihydroxy-1,4-dithiane
Purity
>96.0%(GC)
Packaging
25g
Price
$48
Updated
2025/07/31
TCI Chemical
Product number
D1761
Product name
2,5-Dihydroxy-1,4-dithiane
Purity
>96.0%(GC)
Packaging
500g
Price
$568
Updated
2025/07/31
Sigma-Aldrich
Product number
W382604
Product name
2,5-Dihydroxy-1,4-dithiane
Purity
mixture of isomers, ≥97%, FG
Packaging
sample
Price
$53.8
Updated
2022/05/15
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2,5-Dihydroxy-1,4-dithiane Chemical Properties,Usage,Production

Chemical Properties

2,5-Dihydroxy-1,4-dithiane has a sulfurous, meaty, toasted bread-like odor

Chemical Properties

white to yellowish crystalline powder

Uses

1,4-Dithiane-2,5-diol is a hydroxylated dithiane derivative with phytogrowth-inhibitory and antibacterial activities.

Uses

1,4-Dithiane-2,5-diol was used in the synthesis of:

  • substituted tetrahydrothiophene derivatives
  • 2-amino-3-(arylsulfonyl)thiophenes, potential antiviral and antitumor agents

Definition

ChEBI: 1,4-Dithiane-2,5-diol is a member of dithianes.

Aroma threshold values

Aroma characteristics at 0.1% EtoH: sulfurous, grilled meaty, pungent, brothy, eggy, heavy and rich, toasted bread, tomato

Taste threshold values

Taste characteristics at 0.25 to 10 ppm: metallic, meaty savory chicken and beef, sulfurous, egg-yolk-like

Synthesis Reference(s)

Synthetic Communications, 14, p. 483, 1984 DOI: 10.1080/00397918408059569

General Description

1,4-Dithiane-2,5-diol undergoes bifunctional squaramide catalyzed sulfa-Michael/aldol cascade reaction with chalcones to afford trisubstituted tetrahydrothiophenes. It participates in diastereoselective [3+3] cycloaddition with azomethine imines catalyzed by 1,4-diazabicyclo[2.2.2]octane. It is a mercaptoacetaldehyde dimer and an efficient synthon for incorporating a thiol group to in situ generated nitroalkenes.

2,5-Dihydroxy-1,4-dithiane Preparation Products And Raw materials

Raw materials

Preparation Products

Methyl 2-aminothiophene-3-carboxylate 3-METHOXYCARBONYL-3-SULFOLENE
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2,5-Dihydroxy-1,4-dithiane Suppliers

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View Lastest Price from 2,5-Dihydroxy-1,4-dithiane manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
2,5-Dihydroxy-1,4-dithiane 40018-26-6
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
5tons
Release date
2024-12-05
Hebei Chuanghai Biotechnology Co., Ltd
Product
2,5-Dihydroxy-1,4-dithiane 40018-26-6
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-11-01
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
2,5-Dihydroxy-1,4-dithiane 40018-26-6
Price
US $56.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000kg/week
Release date
2024-05-21

40018-26-6, 2,5-Dihydroxy-1,4-dithianeRelated Search:

Solvent Red 43 Triclosan 1,4-Butanediol DL-Dithiothreitol Chrysin Dimethyl disulfide 1-Hydroxyethylidene-1,1-diphosphonic acid 1,3-Dihydroxyacetone Butylated Hydroxytoluene Selenium sulfide 1,2-Pentanediol 3-Diethylaminophenol Ethyl 2-hydroxyethyl sulfide 4-Dithiane-2,5-diol,2,5-dimethyl- 1,4-Dithiane 1,2-Ethanedithiol 2-(3,4-Dimethoxyphenyl)-N-(3,4-dimethoxyphenethyl)-N-methyl-1,3-dithiane-2-propan-1-amine 1,1,3,3-tetraoxide trans-1,2-Dithiane-4,5-diol, Oxidized DTT,trans-1,2-dithiane-4,5-diol,trans-1,2-Dithiane-4,5-diol, Oxidized DTT,rel-(4R*,5R*)-1,2-Dithiane-4,5-diol

  • 1,4-DITHIANE-2,5-DIOL
  • 2,5-DIHYDROXY-1,4-DITHIANE
  • 4-DITHIANE-2,5-DIOL
  • MERCATOACETALDEHYDE DIMER
  • p-Dithiane-2,5-diol, 95% 250GR
  • 1,4-Dithiane-2,5-dio
  • 1,4-Dithian-2,5-diol
  • NSC 106280
  • 1,4-Dithiane-2,5-diol Mercaptoacetaldehyde Dimer
  • p-Dithiane-2,5-diol C4H8O2S2
  • Dihydroxy-1,4-dit
  • 2,5-Dihydroxy-1,4-dithiane, 98%, Mixture of isoMers
  • 1,4-DITHIANE-2,5-DIOL 2,5-DIHYDROXY-1,4-DITHIANE 4-DITHIANE-2,5-DIOL DITHIANE FEMA 3826
  • 2,5-Dihydroxy-1,4-dithiane, Mixture of isoMers
  • 2,5-Dihydroxy-1,4-Dithiance
  • 2,5-Dihydroxy-1,4-dithiane, 97%, mixture of isomers
  • 2.5- twohydroxytwo -1.4-dithiane
  • MERCAPTOACETALDEHYDE DIMER
  • DITHIANE
  • LABOTEST-BB LT00138118
  • FEMA 3826
  • p-Dithiane-2,5-diol
  • 2 5-DIHYDROXY-1 4-DITHIANE 97+% MIXTU&
  • 2,5-DIHYDROXY-1,4-DITHIANE, WACKERQUALIT Y
  • 2,5-Dihydroxy-1,4-dithiane, pract., 95+%
  • 2,5-DIHYDROXY-1,4-DITHIANE, 90+%
  • 2,5-dimethyl-1,4-dithiane
  • tetrahydro-p-dithiin
  • 1,4-dithane-2,5-diol
  • 2,5-Dihydroxy-1,4-dithiane, Mercaptoacetaldehyde dimer
  • 1,4-Dithiane-2,5-diol, 2,5-Dihydroxy-1,4-dithiane, Mercaptoacetaldehyde dimer
  • p-Dithiane-2,5-diol,95%
  • 4-dithiane
  • 5-Dihydroxy-1
  • (2S,5R)-1,4-dithiane-2,5-diol
  • 2,5-Dihydroxy-1,4-dithiane&gt
  • 2,5-Dihydroxy-1,4-dithiane[DHDT]
  • 1, 4-dithio-2, 5-diol
  • 2,5-Dihydroxy-1,4-dithiane, 97%+
  • p-Dithiane-2,5-diol, 96%,
  • 2,5-Dihydroxy-1,4-Dithuane
  • 1,4-Dithiane-2,5-diol (9CI, ACI)
  • 2,5-Dihydroxy-1,4-dithiane/1,4-DITHIANE-2,5-DIOL
  • 1,4-dithial-2,5-diol
  • DHDT
  • 2,5-Dihydroxy-1,4-thiadiane
  • 2,5-dihydroxy-1,4-dithiane（reach）
  • 40018-26-6
  • CH2SCH2CH2SCH2
  • C4H8O2S2
  • C4H8O2S2C4H8O2S2C4H8O2S2C4H8O2S2
  • Heterocyclic Building Blocks
  • Others
  • S-Containing
  • Building Blocks
  • Heterocyclic Compounds
  • aldehyde Flavor
  • Building Blocks