CGP 78608 HYDROCHLORIDE
- Product Name
- CGP 78608 HYDROCHLORIDE
- CAS No.
- 206648-13-7
- Chemical Name
- CGP 78608 HYDROCHLORIDE
- Synonyms
- CGP78608HCl;CGP 78608 hydrochlor;CGP 78608 HYDROCHLORIDE;Phosphonic acid, P-[(1S)-1-[[(7-bromo-1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)methyl]amino]ethyl]-;((1S)-1-(((7-Bromo-1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)methyl)amino)ethyl]phosphonicacidhydrochloride;[(1S)-1-[[(7-BROMO-1,2,3,4-TETRAHYDRO-2,3-DIOXO-5-QUINOXALINYL)METHYL]AMINO]ETHYL]PHOSPHONIC ACID HYDROCHLORIDE
- CBNumber
- CB4141516
- Molecular Formula
- C11H13BrN3O5P
- Formula Weight
- 378.12
- MOL File
- 206648-13-7.mol
CGP 78608 HYDROCHLORIDE Property
- Density
- 1.757±0.06 g/cm3(Predicted)
- storage temp.
- Store at RT
- solubility
- <41.46mg/ml in 2.2eq. NaOH
- pka
- 0.66±0.10(Predicted)
N-Bromosuccinimide Price
- Product number
- 1493
- Product name
- CGP78608hydrochloride
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $227
- Updated
- 2021/12/16
- Product number
- 1493
- Product name
- CGP78608hydrochloride
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $936
- Updated
- 2021/12/16
- Product number
- C583563
- Product name
- CGP78608
- Packaging
- 25mg
- Price
- $305
- Updated
- 2021/12/16
- Product number
- API0009990
- Product name
- CGP 78608 HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $497.49
- Updated
- 2021/12/16
- Product number
- B6762
- Product name
- CGP78608hydrochloride
- Packaging
- 50mg
- Price
- $1399
- Updated
- 2021/12/16
CGP 78608 HYDROCHLORIDE Chemical Properties,Usage,Production
Uses
CGP 78608 is a potent and selective NMDA antagonist.
Definition
ChEBI: CGP 78608 is a phosphonic acid in which the hydrogen attached to phosphorous is substituted by a 1-{[(7-bromo-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)methyl]amino}ethyl group. Potent and selective NMDA antagonist that acts through the glycine site (IC50 = 5 nM). Displays >500-fold selectivity over kainate and AMPA receptors (IC50 values are 2.7 and 3 muM respectively). Anticonvulsant in vivo following systemic administration. It has a role as a NMDA receptor antagonist and an anticonvulsant. It is a quinoxaline derivative, an organobromine compound, a secondary amino compound and a member of phosphonic acids. It contains a CGP 78608(1+).
Biological Activity
Potent and selective NMDA antagonist that acts through the glycine site (IC 50 = 5 nM). Displays > 500-fold selectivity over kainate and AMPA receptors (IC 50 values are 2.7 and 3 μ M respectively). Anticonvulsant in vivo following systemic administration. Also available as part of the NMDA Receptor - Glycine Site Tocriset™ .
in vivo
CGP-78608 displays potent anticonvulsant effects after i.p. administration in the electroshock-induced convulsions assay in mice[1].
CGP 78608 HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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