ChemicalBook > CAS DataBase List > Xanomeline

Xanomeline

Product Name: Xanomeline
CAS No.: 131986-45-3
Chemical Name: Xanomeline
Synonyms: XANOMELINE;Memcor;Lomeron;LY-246708;NNC-11-0232;3-(Hexyloxy);Xanomeline(LY-246708);JNJ-7777120 (Zanoterone);Xanomeline, 10 mM in DMSO;Xanomeline L-tartrate hydrate
CBNumber: CB4144966
Molecular Formula: C14H23N3OS
Formula Weight: 281.42
MOL File: 131986-45-3.mol

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Xanomeline Property

Boiling point:: 397.0±42.0 °C(Predicted)
Density: 1.101±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: H2O: soluble10mg/mL, clear (warmed)
form: powder
pka: 7.34±0.40(Predicted)
color: off-white
InChI: InChI=1S/C14H23N3OS/c1-3-4-5-6-10-18-14-13(15-19-16-14)12-8-7-9-17(2)11-12/h8H,3-7,9-11H2,1-2H3
InChIKey: JOLJIIDDOBNFHW-UHFFFAOYSA-N
SMILES: C1N(C)CCC=C1C1C(OCCCCCC)=NSN=1

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: X2754
Product name: Xanomeline L-tartrate hydrate
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $905
Updated: 2022/05/15

TRC

Product number: H298183
Product name: 3-(Hexyloxy)-4-(1-Methyl-1,2,5,6-Tetrahydropyridin-3-Yl)-1,2,5-Thiadiazole
Packaging: 25mg
Price: $220
Updated: 2021/12/16

Matrix Scientific

Product number: 097008
Product name: 3-(Hexyloxy)-4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)-1,2,5-thiadiazole
Purity: 95+%
Packaging: 250mg
Price: $695
Updated: 2021/12/16

Matrix Scientific

Product number: 097008
Product name: 3-(Hexyloxy)-4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)-1,2,5-thiadiazole
Purity: 95+%
Packaging: 500mg
Price: $1073
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0008412
Product name: XANOMELINE L-TARTRATE HYDRATE
Purity: 95.00%
Packaging: 25MG
Price: $1294.01
Updated: 2021/12/16

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Xanomeline Chemical Properties,Usage,Production

Description

Xanomeline is used as a potent and selective muscarinic type 1 and type 4 (M1/M4) receptor agonist to increase neuronal excitability. Xanomeline is used in studies of neurological disorders such as Alzheimer's disease and schizophrenia. However, development of the drug was halted due to severe cholinergic adverse effects. Currently, xanomeline-trospium (KarXT) (a peripheral cholinergic antagonist) has been explored for the treatment of schizophrenia and a New Drug Application has been filed with the FDA, with a decision on whether it will be approved or not expected on 26 September 2024.

Chemical Properties

Xanomeline Oxalate: C14H23N3OS?C2H2O4. [141064-23-5]. Crystallized from acetone, melting point 148°C.
(+)-L-Tartrate: C14H23N3OS?C4H6O6. [152854-19-8]. Crystallized from 2-propanol, melting point 95.5°C.

Uses

Alzheimer’s disease treatment (cholinergic agonist).

Definition

ChEBI: Xanomeline is a member of thiadiazoles and a tetrahydropyridine. It has a role as a muscarinic agonist and a serotonergic agonist.

Mechanism of action

Xanomeline's mechanism of action is is to rebalance key neurotransmitter circuits, including acetylcholine, dopamine and glutamate, which are disrupted in schizophrenia and related disorders.

in vivo

Xanomeline (0.5~3 mg/kg; s.c.; 1~3 hours) induces salivation and vomiting in some monkeys^[3].
Xanomeline shows functional dopamine antagonism and an antipsychotic-like profile. Xanomeline inhibits D-amphetamine- and ( )-apomorphine-induced behavior and do not cause extrapyramidal side effects^[3].

Animal Model:	Male Cebus apella monkeys
Dosage:	0.5~3 mg/kg
Administration:	S.c.; 1~3 hours
Result:	Induced salivation and vomiting in some monkeys.

IC 50

mAChR1; mAChR4

Xanomeline Preparation Products And Raw materials

Raw materials

3-PYRIDYLACETONITRILE Sodium borohydride Sodium hexylate Iodomethane Praseodymium(III) nitrate hexahydrate Formamide

Preparation Products

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View Lastest Price from Xanomeline manufacturers

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Xanomeline 131986-45-3
Price: US $0.00/mg
Min. Order: 10mg
Purity: 0.98
Supply Ability: 5g
Release date: 2025-02-14

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Xanomeline Impurity 1 131986-45-3
Price: US $0.00/mg
Min. Order: 10mg
Purity: 0.98
Supply Ability: 5g
Release date: 2025-02-14

Shaanxi Dideu New Materials Co. Ltd

Product: Xanomeline 131986-45-3
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 5000KGS
Release date: 2024-11-12

131986-45-3, XanomelineRelated Search:

(-)-Huperzine A Donepezil SABCOMELINE 1,2,5-THIADIAZOL-3-OL 5-(4-HEXYLOXY-[1,2,5]THIADIAZOL-3-YL)-1-METHYL-1,2,3,6-TETRAHYDRO-PYRIDINE Xanomeline metabolite A 3-(hexyloxy)-4-(pyridin-3-yl)-1,2,5-thiadiazole Pyridinium, 5-[4-(hexyloxy)-1,2,5-thiadiazol-3-yl]-3-hydroxy-1-methyl- Pyridine, 3-[4-(heptyloxy)-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahydro-1-methyl- Xanomeline Metabolite B 3-Pyridineacetonitrile, α-hydroxy- bis(4-(pyridin-3-yl)-1,2,5-thiadiazol-3-yl)sulfane 3-(4-HEXYLOXY-1,2,5-THIADIAZOL-3-YL)-1-METHYLPYRIDINIUM IODIDE Pyridine, 3-(1,2,5-thiadiazol-3-yl)-

3-[4-(Hexy loxy)-1，2，5-thiadiazol-3-y1]-1，2，5，6-tetrahydro-1-methylpyridine

5-(4-HEXYLOXY-[1,2,5]THIADIAZOL-3-YL)-1-METHYL-1,2,3,6-TETRAHYDRO-PYRIDINE

XANOMELINE

Lomeron

LY-246708

Memcor

NNC-11-0232

3-(Hexyloxy)-4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)-1,2,5-thiadiazole

Xanomeline L-tartrate hydrate

3-(Hexyloxy)

-4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)

3-Hexoxy-4-(1-methyl-3,6-dihydro-2H-pyridin-5-yl)-1,2,5-thiadiazole

Pyridine, 3-[4-(hexyloxy)-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahydro-1-methyl-

Xanomeline L-tartrate hydrate >=98% (HPLC)

5-(4-HEXYLOXY-[1,2,5]THIADIAZOL-3-YL)-1-METHYL-1,2,3,6-TETRAHYDRO-PYRIDINE USP/EP/BP

Xanomeline(LY-246708)

3-(Hexyloxy)-4-(1-methyl-1,2,5,6-tetrahydro-3-pyridyl)-1,2,5-thiadiazole

Xanomeline, 10 mM in DMSO

JNJ-7777120 (Zanoterone)

131986-45-3

C14H23N3OS

API