ChemicalBook > CAS DataBase List > Xanomeline

Xanomeline

Product Name
Xanomeline
CAS No.
131986-45-3
Chemical Name
Xanomeline
Synonyms
XANOMELINE;Memcor;Lomeron;LY-246708;NNC-11-0232;3-(Hexyloxy);Xanomeline(LY-246708);Xanomeline L-tartrate hydrate;Xanomeline L-tartrate hydrate >=98% (HPLC);-4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)
CBNumber
CB4144966
Molecular Formula
C14H23N3OS
Formula Weight
281.42
MOL File
131986-45-3.mol
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Xanomeline Property

Boiling point:
397.0±42.0 °C(Predicted)
Density 
1.101±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
solubility 
H2O: soluble10mg/mL, clear (warmed)
form 
powder
pka
7.34±0.40(Predicted)
color 
off-white
InChIKey
JOLJIIDDOBNFHW-UHFFFAOYSA-N
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
X2754
Product name
Xanomeline L-tartrate hydrate
Purity
≥98% (HPLC)
Packaging
25mg
Price
$905
Updated
2022/05/15
TRC
Product number
H298183
Product name
3-(Hexyloxy)-4-(1-Methyl-1,2,5,6-Tetrahydropyridin-3-Yl)-1,2,5-Thiadiazole
Packaging
25mg
Price
$220
Updated
2021/12/16
Matrix Scientific
Product number
097008
Product name
3-(Hexyloxy)-4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)-1,2,5-thiadiazole
Purity
95+%
Packaging
250mg
Price
$695
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0008412
Product name
XANOMELINE L-TARTRATE HYDRATE
Purity
95.00%
Packaging
5MG
Price
$767.38
Updated
2021/12/16
Matrix Scientific
Product number
097008
Product name
3-(Hexyloxy)-4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)-1,2,5-thiadiazole
Purity
95+%
Packaging
500mg
Price
$1073
Updated
2021/12/16
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Xanomeline Chemical Properties,Usage,Production

Description

Xanomeline is used as a potent and selective muscarinic type 1 and type 4 (M1/M4) receptor agonist to increase neuronal excitability. Xanomeline is used in studies of neurological disorders such as Alzheimer's disease and schizophrenia. However, development of the drug was halted due to severe cholinergic adverse effects. Currently, xanomeline-trospium (KarXT) (a peripheral cholinergic antagonist) has been explored for the treatment of schizophrenia and a New Drug Application has been filed with the FDA, with a decision on whether it will be approved or not expected on 26 September 2024.

Uses

Alzheimer’s disease treatment (cholinergic agonist).

Definition

ChEBI: Xanomeline is a member of thiadiazoles and a tetrahydropyridine. It has a role as a muscarinic agonist and a serotonergic agonist.

Mechanism of action

Xanomeline's mechanism of action is is to rebalance key neurotransmitter circuits, including acetylcholine, dopamine and glutamate, which are disrupted in schizophrenia and related disorders.

Xanomeline Preparation Products And Raw materials

Raw materials

3-PYRIDYLACETONITRILE Sodium borohydride Sodium hexylate Iodomethane Praseodymium(III) nitrate hexahydrate Formamide

Preparation Products

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Xanomeline Suppliers

China 77 Germany 1 India 3 Sweden 1 United Kingdom 1 United States 11 Global 94
Huayin Sample Biological Technology Co. LTD
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View Lastest Price from Xanomeline manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
Xanomeline 131986-45-3
Price
US $0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
5000KGS
Release date
2024-11-12
Dideu Industries Group Limited
Product
5-(4-HEXYLOXY-[1,2,5]THIADIAZOL-3-YL)-1-METHYL-1,2,3,6-TETRAHYDRO-PYRIDINE 131986-45-3
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-05-28
Career Henan Chemical Co
Product
5-(4-HEXYLOXY-[1,2,5]THIADIAZOL-3-YL)-1-METHYL-1,2,3,6-TETRAHYDRO-PYRIDINE 131986-45-3
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-13

131986-45-3, XanomelineRelated Search:

(-)-Huperzine A Donepezil SABCOMELINE 1,2,5-THIADIAZOL-3-OL 5-(4-HEXYLOXY-[1,2,5]THIADIAZOL-3-YL)-1-METHYL-1,2,3,6-TETRAHYDRO-PYRIDINE

  • 3-[4-(Hexy loxy)-1，2，5-thiadiazol-3-y1]-1，2，5，6-tetrahydro-1-methylpyridine
  • 5-(4-HEXYLOXY-[1,2,5]THIADIAZOL-3-YL)-1-METHYL-1,2,3,6-TETRAHYDRO-PYRIDINE
  • XANOMELINE
  • Lomeron
  • LY-246708
  • Memcor
  • NNC-11-0232
  • 3-(Hexyloxy)-4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)-1,2,5-thiadiazole
  • Xanomeline L-tartrate hydrate
  • 3-(Hexyloxy)
  • -4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)
  • 3-Hexoxy-4-(1-methyl-3,6-dihydro-2H-pyridin-5-yl)-1,2,5-thiadiazole
  • Pyridine, 3-[4-(hexyloxy)-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahydro-1-methyl-
  • Xanomeline L-tartrate hydrate >=98% (HPLC)
  • 5-(4-HEXYLOXY-[1,2,5]THIADIAZOL-3-YL)-1-METHYL-1,2,3,6-TETRAHYDRO-PYRIDINE USP/EP/BP
  • Xanomeline(LY-246708)
  • 3-(Hexyloxy)-4-(1-methyl-1,2,5,6-tetrahydro-3-pyridyl)-1,2,5-thiadiazole
  • 131986-45-3
  • C14H23N3OS
  • API