Xanomeline

Product Name: Xanomeline
CAS No.: 131986-45-3
Chemical Name: Xanomeline
Synonyms: XANOMELINE;Memcor;Lomeron;LY-246708;NNC-11-0232;3-(Hexyloxy);Xanomeline(LY-246708);Xanomeline L-tartrate hydrate;Xanomeline L-tartrate hydrate >=98% (HPLC);-4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)
CBNumber: CB4144966
Molecular Formula: C14H23N3OS
Formula Weight: 281.42
MOL File: 131986-45-3.mol

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Xanomeline Property

Boiling point:: 397.0±42.0 °C(Predicted)
Density: 1.101±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: H2O: soluble10mg/mL, clear (warmed)
form: powder
pka: 7.34±0.40(Predicted)
color: off-white
InChIKey: JOLJIIDDOBNFHW-UHFFFAOYSA-N

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: X2754
Product name: Xanomeline L-tartrate hydrate
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $905
Updated: 2022/05/15

TRC

Product number: H298183
Product name: 3-(Hexyloxy)-4-(1-Methyl-1,2,5,6-Tetrahydropyridin-3-Yl)-1,2,5-Thiadiazole
Packaging: 25mg
Price: $220
Updated: 2021/12/16

Matrix Scientific

Product number: 097008
Product name: 3-(Hexyloxy)-4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)-1,2,5-thiadiazole
Purity: 95+%
Packaging: 250mg
Price: $695
Updated: 2021/12/16

Matrix Scientific

Product number: 097008
Product name: 3-(Hexyloxy)-4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)-1,2,5-thiadiazole
Purity: 95+%
Packaging: 500mg
Price: $1073
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0008412
Product name: XANOMELINE L-TARTRATE HYDRATE
Purity: 95.00%
Packaging: 25MG
Price: $1294.01
Updated: 2021/12/16

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Xanomeline Chemical Properties,Usage,Production

Description

Xanomeline is used as a potent and selective muscarinic type 1 and type 4 (M1/M4) receptor agonist to increase neuronal excitability. Xanomeline is used in studies of neurological disorders such as Alzheimer's disease and schizophrenia. However, development of the drug was halted due to severe cholinergic adverse effects. Currently, xanomeline-trospium (KarXT) (a peripheral cholinergic antagonist) has been explored for the treatment of schizophrenia and a New Drug Application has been filed with the FDA, with a decision on whether it will be approved or not expected on 26 September 2024.

Uses

Alzheimer’s disease treatment (cholinergic agonist).

Definition

ChEBI: Xanomeline is a member of thiadiazoles and a tetrahydropyridine. It has a role as a muscarinic agonist and a serotonergic agonist.

Mechanism of action

Xanomeline's mechanism of action is is to rebalance key neurotransmitter circuits, including acetylcholine, dopamine and glutamate, which are disrupted in schizophrenia and related disorders.

Xanomeline Preparation Products And Raw materials

Raw materials

3-PYRIDYLACETONITRILE Sodium borohydride Sodium hexylate Iodomethane Praseodymium(III) nitrate hexahydrate Formamide

Preparation Products

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Xanomeline Suppliers

China 56 Germany 1 India 3 Sweden 1 United Kingdom 1 United States 9 Global 71

Huayin Sample Biological Technology Co. LTD

Tel: 13892502238
Email: 1453186328@qq.com
Country: China
ProdList: 500
Advantage: 58

Shanghai Jidu Biotechnology Co., Ltd.

Tel: 13851761812
Email: 13851761812@163.com
Country: China
ProdList: 494
Advantage: 58

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2127
Advantage: 70

NCE Biomedical Co.,Ltd.

Tel: 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax: +86-27-87599188
Country: China
ProdList: 1494
Advantage: 55

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 17994
Advantage: 56

Finetech Industry Limited

Tel: 027-87465837 19945049750
Fax: 027-8777-2287
Email: sales@finetechnology-ind.com
Country: China
ProdList: 9636
Advantage: 58

LETOPHARM LIMITED

Tel: +86-21-5821 5861
Fax: +86-21-5106 2861
Email: sales@letopharm.com
Country: China
ProdList: 2384
Advantage: 58

Hubei Chuangliankangcheng Pharmaceutical Co., Ltd.

Tel: 027-65388397 18164111589
Fax: 027-65388397
Email: 3321478047@qq.com
Country: China
ProdList: 1969
Advantage: 55

ChengDu TongChuangYuan Pharmaceutical Co.Ltd

Tel: 028-83379370 13880556291
Fax: 028-87747383
Email: tcy@tcypharm.com
Country: China
ProdList: 5463
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131981
Advantage: 58

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View Lastest Price from Xanomeline manufacturers

Dideu Industries Group Limited

Product: 5-(4-HEXYLOXY-[1,2,5]THIADIAZOL-3-YL)-1-METHYL-1,2,3,6-TETRAHYDRO-PYRIDINE 131986-45-3
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2021-05-28

Career Henan Chemical Co

Product: 5-(4-HEXYLOXY-[1,2,5]THIADIAZOL-3-YL)-1-METHYL-1,2,3,6-TETRAHYDRO-PYRIDINE 131986-45-3
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-13

131986-45-3, XanomelineRelated Search:

(-)-Huperzine A Donepezil SABCOMELINE 1,2,5-THIADIAZOL-3-OL 5-(4-HEXYLOXY-[1,2,5]THIADIAZOL-3-YL)-1-METHYL-1,2,3,6-TETRAHYDRO-PYRIDINE

3-[4-(Hexy loxy)-1，2，5-thiadiazol-3-y1]-1，2，5，6-tetrahydro-1-methylpyridine

5-(4-HEXYLOXY-[1,2,5]THIADIAZOL-3-YL)-1-METHYL-1,2,3,6-TETRAHYDRO-PYRIDINE

XANOMELINE

Lomeron

LY-246708

Memcor

NNC-11-0232

3-(Hexyloxy)-4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)-1,2,5-thiadiazole

Xanomeline L-tartrate hydrate

3-(Hexyloxy)

-4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)

3-Hexoxy-4-(1-methyl-3,6-dihydro-2H-pyridin-5-yl)-1,2,5-thiadiazole

Pyridine, 3-[4-(hexyloxy)-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahydro-1-methyl-

Xanomeline L-tartrate hydrate >=98% (HPLC)

5-(4-HEXYLOXY-[1,2,5]THIADIAZOL-3-YL)-1-METHYL-1,2,3,6-TETRAHYDRO-PYRIDINE USP/EP/BP

Xanomeline(LY-246708)

3-(Hexyloxy)-4-(1-methyl-1,2,5,6-tetrahydro-3-pyridyl)-1,2,5-thiadiazole

131986-45-3

C14H23N3OS