4-Hydroxy-2-methylthiazole-5-carboxylicacidethylester
- Product Name
- 4-Hydroxy-2-methylthiazole-5-carboxylicacidethylester
- CAS No.
- 20737-48-8
- Chemical Name
- 4-Hydroxy-2-methylthiazole-5-carboxylicacidethylester
- Synonyms
- ethyl 4-hydroxy-2-Methylthiazole-5-carboxylate;5-[ethoxy(hydroxy)methylidene]-2-methyl-4-thiazolone;Ethyl 4-Hydroxy-2-Methylthiazole-5-Carboxylate(WXC04202);5-Thiazolecarboxylic acid, 4-hydroxy-2-methyl-, ethyl ester;(5E)-5-[ethoxy(hydroxy)methylidene]-2-methyl-1,3-thiazol-4-one
- CBNumber
- CB41450862
- Molecular Formula
- C7H9NO3S
- Formula Weight
- 187.22
- MOL File
- 20737-48-8.mol
4-Hydroxy-2-methylthiazole-5-carboxylicacidethylester Property
- Melting point:
- 104°
- Boiling point:
- 270.7±20.0 °C(Predicted)
- Density
- 1.325±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 8.56±0.20(Predicted)
Safety
- HS Code
- 2934100090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- E945590
- Product name
- Ethyl4-Hydroxy-2-methylthiazole-5-carboxylate
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- W4355
- Product name
- Ethyl4-hydroxy-2-methylthiazole-5-carboxylate
- Packaging
- 250mg
- Price
- $74
- Updated
- 2021/12/16
- Product number
- CS-W019698
- Product name
- ethyl4-hydroxy-2-methylthiazole-5-carboxylate
- Packaging
- 5g
- Price
- $92
- Updated
- 2021/12/16
- Product number
- W4355
- Product name
- Ethyl4-hydroxy-2-methylthiazole-5-carboxylate
- Packaging
- 1g
- Price
- $96
- Updated
- 2021/12/16
- Product number
- 8H70-1-5H
- Product name
- Ethyl 4-hydroxy-2-methyl-1,3-thiazole-5-carboxylate
- Packaging
- 1g
- Price
- $160
- Updated
- 2021/12/16
4-Hydroxy-2-methylthiazole-5-carboxylicacidethylester Chemical Properties,Usage,Production
Synthesis
62-55-5
685-87-0
20737-48-8
5.2 Synthesis of 2-methyl-5-ethoxycarbonyl-4-hydroxythiazole: Diethyl 2-bromomalonate (168 g, 0.7 mol) was slowly added to a 400 mL solution of toluene containing thioacetamide (52.5 g, 0.7 mol). The reaction mixture was heated to reflux for 1 hour. Upon completion of the reaction, the mixture was cooled to room temperature and filtered through a diatomaceous earth pad. Subsequently, the toluene was evaporated under reduced pressure to give a viscous oily crude product. This crude product was mixed with 500 mL of water and stirred until solids precipitated. The solid product was collected by filtration, washed sequentially with water (3 x 300 mL) and petroleum ether, and finally dried under high vacuum to afford 55 g of methyl 4-hydroxy-2-methylthiazole-5-carboxylate (yield: 42%; LC retention time: 1.24 min; MS: [M+H]+ = 188).
References
[1] Patent: WO2005/97766, 2005, A1. Location in patent: Page/Page column 28-29
[2] Patent: WO2010/59838, 2010, A2. Location in patent: Page/Page column 124
[3] Patent: WO2014/82737, 2014, A1. Location in patent: Page/Page column 43
[4] Patent: WO2008/152390, 2008, A1. Location in patent: Page/Page column 33; 46-47
[5] Journal of Medicinal Chemistry, 2014, vol. 57, # 3, p. 970 - 986
4-Hydroxy-2-methylthiazole-5-carboxylicacidethylester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Hydroxy-2-methylthiazole-5-carboxylicacidethylester manufacturers
- Product
- 4-Hydroxy-2-methylthiazole-5-carboxylicacidethylester 20737-48-8
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-14