ChemicalBook > CAS DataBase List > 4-Hydroxy-2-methylthiazole-5-carboxylicacidethylester

4-Hydroxy-2-methylthiazole-5-carboxylicacidethylester

Product Name
4-Hydroxy-2-methylthiazole-5-carboxylicacidethylester
CAS No.
20737-48-8
Chemical Name
4-Hydroxy-2-methylthiazole-5-carboxylicacidethylester
Synonyms
ethyl 4-hydroxy-2-Methylthiazole-5-carboxylate;5-[ethoxy(hydroxy)methylidene]-2-methyl-4-thiazolone;Ethyl 4-Hydroxy-2-Methylthiazole-5-Carboxylate(WXC04202);5-Thiazolecarboxylic acid, 4-hydroxy-2-methyl-, ethyl ester;(5E)-5-[ethoxy(hydroxy)methylidene]-2-methyl-1,3-thiazol-4-one
CBNumber
CB41450862
Molecular Formula
C7H9NO3S
Formula Weight
187.22
MOL File
20737-48-8.mol
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4-Hydroxy-2-methylthiazole-5-carboxylicacidethylester Property

Melting point:
104°
Boiling point:
270.7±20.0 °C(Predicted)
Density 
1.325±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
pka
8.56±0.20(Predicted)
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Safety

HS Code 
2934100090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
E945590
Product name
Ethyl4-Hydroxy-2-methylthiazole-5-carboxylate
Packaging
100mg
Price
$60
Updated
2021/12/16
AK Scientific
Product number
W4355
Product name
Ethyl4-hydroxy-2-methylthiazole-5-carboxylate
Packaging
250mg
Price
$74
Updated
2021/12/16
SynQuest Laboratories
Product number
8H70-1-5H
Product name
Ethyl 4-hydroxy-2-methyl-1,3-thiazole-5-carboxylate
Packaging
1g
Price
$160
Updated
2021/12/16
AK Scientific
Product number
W4355
Product name
Ethyl4-hydroxy-2-methylthiazole-5-carboxylate
Packaging
10g
Price
$247
Updated
2021/12/16
ChemScene
Product number
CS-W019698
Product name
ethyl4-hydroxy-2-methylthiazole-5-carboxylate
Packaging
5g
Price
$92
Updated
2021/12/16
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4-Hydroxy-2-methylthiazole-5-carboxylicacidethylester Chemical Properties,Usage,Production

Synthesis

62-55-5

685-87-0

20737-48-8

5.2 Synthesis of 2-methyl-5-ethoxycarbonyl-4-hydroxythiazole: Diethyl 2-bromomalonate (168 g, 0.7 mol) was slowly added to a 400 mL solution of toluene containing thioacetamide (52.5 g, 0.7 mol). The reaction mixture was heated to reflux for 1 hour. Upon completion of the reaction, the mixture was cooled to room temperature and filtered through a diatomaceous earth pad. Subsequently, the toluene was evaporated under reduced pressure to give a viscous oily crude product. This crude product was mixed with 500 mL of water and stirred until solids precipitated. The solid product was collected by filtration, washed sequentially with water (3 x 300 mL) and petroleum ether, and finally dried under high vacuum to afford 55 g of methyl 4-hydroxy-2-methylthiazole-5-carboxylate (yield: 42%; LC retention time: 1.24 min; MS: [M+H]+ = 188).

References

[1] Patent: WO2005/97766, 2005, A1. Location in patent: Page/Page column 28-29
[2] Patent: WO2010/59838, 2010, A2. Location in patent: Page/Page column 124
[3] Patent: WO2014/82737, 2014, A1. Location in patent: Page/Page column 43
[4] Patent: WO2008/152390, 2008, A1. Location in patent: Page/Page column 33; 46-47
[5] Journal of Medicinal Chemistry, 2014, vol. 57, # 3, p. 970 - 986

4-Hydroxy-2-methylthiazole-5-carboxylicacidethylester Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-Hydroxy-2-methylthiazole-5-carboxylicacidethylester manufacturers

Career Henan Chemical Co
Product
4-Hydroxy-2-methylthiazole-5-carboxylicacidethylester 20737-48-8
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-14

20737-48-8, 4-Hydroxy-2-methylthiazole-5-carboxylicacidethylesterRelated Search:

Thiazole-5-carboxylic acid 2-Methylthiazole ETHYL 2-(2-CHLOROPHENYL)-4-HYDROXY-1,3-THIAZOLE-5-CARBOXYLATE ETHYL 4-HYDROXY-2-(4-METHYLPHENYL)-1,3-THIAZOLE-5-CARBOXYLATE ETHYL 4-HYDROXY-2-PHENYL-1,3-THIAZOLE-5-CARBOXYLATE ETHYL 2-(3,4-DIMETHOXYPHENYL)-4-HYDROXY-1,3-THIAZOLE-5-CARBOXYLATE 4-Hydroxy-2-methylthiazole-5-carboxylicacidethylester ETHYL 2-(2,4-DICHLOROPHENYL)-4-HYDROXYTHIAZOLE-5-CARBOXYLATE ETHYL 4-HYDROXY-2-(4-METHOXYPHENYL)-1,3-THIAZOLE-5-CARBOXYLATE ETHYL 4-HYDROXY-2-(2-THIENYL)-1,3-THIAZOLE-5-CARBOXYLATE ETHYL 4-HYDROXY-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOLE-5-CARBOXYLATE ETHYL 2-(4-CHLOROPHENYL)-4-HYDROXY-1,3-THIAZOLE-5-CARBOXYLATE ETHYL 4-HYDROXY-2-[3-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOLE-5-CARBOXYLATE

  • ethyl 4-hydroxy-2-Methylthiazole-5-carboxylate
  • Ethyl 4-Hydroxy-2-Methylthiazole-5-Carboxylate(WXC04202)
  • 5-[ethoxy(hydroxy)methylidene]-2-methyl-4-thiazolone
  • 5-Thiazolecarboxylic acid, 4-hydroxy-2-methyl-, ethyl ester
  • (5E)-5-[ethoxy(hydroxy)methylidene]-2-methyl-1,3-thiazol-4-one
  • 20737-48-8