4-METHOXY-2-(TRIFLUOROMETHYL)PHENYLBORONIC ACID
- Product Name
- 4-METHOXY-2-(TRIFLUOROMETHYL)PHENYLBORONIC ACID
- CAS No.
- 313546-16-6
- Chemical Name
- 4-METHOXY-2-(TRIFLUOROMETHYL)PHENYLBORONIC ACID
- Synonyms
- 4-Methoxy-2-(trifL;4-METHOXY-2-(TRIFLUOROMETHYL)PHENYLBORO&;4-METHOXY-2-(TRIFLUOROMETHYL)PHENYLBRONIC ACID;4-METHOXY-2-(TRIFLUOROMETHYL)PHENYLBORONIC ACID;4-METHOXY-2-(TRIFLUOROMETHYL)BENZENEBORONIC ACID;Boronic acid, B-?[4-?methoxy-?2-?(trifluoromethyl)?phenyl]?-;2-Borono-5-methoxybenzotrifluoride, 4-Borono-3-(trifluoromethyl)anisole;4-Methoxy-2-(trifluoromethyl)phenylboronic Acid (contains varying amounts of Anhydride)
- CBNumber
- CB4145251
- Molecular Formula
- C8H8BF3O3
- Formula Weight
- 219.95
- MOL File
- 313546-16-6.mol
4-METHOXY-2-(TRIFLUOROMETHYL)PHENYLBORONIC ACID Property
- Melting point:
- 168-172 °C
- Boiling point:
- 314.1±52.0 °C(Predicted)
- Density
- 1.36±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 8.54±0.58(Predicted)
- form
- powder to crystal
- color
- White to Almost white
- InChI
- 1S/C8H8BF3O3/c1-15-5-2-3-7(9(13)14)6(4-5)8(10,11)12/h2-4,13-14H,1H3
- InChIKey
- ZBCRZEJNAADYKG-UHFFFAOYSA-N
- SMILES
- COc1ccc(B(O)O)c(c1)C(F)(F)F
- CAS DataBase Reference
- 313546-16-6(CAS DataBase Reference)
Safety
- WGK Germany
- 3
- HS Code
- 2931900090
- Storage Class
- 11 - Combustible Solids
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 666912
- Product name
- 4-Methoxy-2-(trifluoromethyl)phenylboronic acid
- Purity
- ≥95%
- Packaging
- 5g
- Price
- $422
- Updated
- 2023/01/07
- Product number
- 666912
- Product name
- 4-Methoxy-2-(trifluoromethyl)phenylboronic acid
- Purity
- ≥95%
- Packaging
- 1g
- Price
- $142
- Updated
- 2022/05/15
- Product number
- M2853
- Product name
- 4-Methoxy-2-(trifluoromethyl)phenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 1g
- Price
- $98
- Updated
- 2024/03/01
- Product number
- M220185
- Product name
- 4-Methoxy-2-(trifluoromethyl)phenylboronic acid
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- N824
- Product name
- 4-Methoxy-2-(trifluoromethyl)phenylboronic acid
- Packaging
- 250mg
- Price
- $20
- Updated
- 2021/12/16
4-METHOXY-2-(TRIFLUOROMETHYL)PHENYLBORONIC ACID Chemical Properties,Usage,Production
Uses
Reactant involved in:• ;Synthesis of pyrazine derivatives as corticotropin releasing factor-1 receptor antagonists1• ;C-H functionalization of quinones1• ;Phenyl-purine-carbonitrile derivative synthesis as cathepsin S inhibitors2• ;Synthesis of chiral bicyclooctadiene-based ligands3• ;Synthesis of corticotropin-releasing factor-1 antagonists4
Uses
suzuki reaction
Uses
Reactant involved in:
- Synthesis of pyrazine derivatives as corticotropin releasing factor-1 receptor antagonists
- C-H functionalization of quinones
- Phenyl-purine-carbonitrile derivative synthesis as cathepsin S inhibitors
- Synthesis of chiral bicyclooctadiene-based ligands
- Synthesis of corticotropin-releasing factor-1 antagonists
Synthesis
Three.0 g (8.85 mmol) of potassium phosphate heptahydrate, 1.50 g (5.90 mmol) of bis(boronic acid) pinacol ester B2(pin)2, 12 mg (0.015 mmol) Xphos-Pd-G2 and 4 mg (0.008 mmol) Xphos were added sequentially to the reaction vial, 6 mL of ethanol was added and stirred well, then 0.36 mL (2.95 mmol) 4-methoxy-2-(trifluoromethyl)chlorobenzene and reacted for 1 hour at room temperature. The reaction solution was diluted by adding 5mL of ethyl acetate, filtered through diatomaceous earth, washed by ethyl acetate, the filtrates were combined and concentrated under reduced pressure to obtain the crude product, which was separated by silica gel column chromatography, eluting with petroleum ether-ethyl acetate to obtain 4-methoxy-2-(trifluoromethyl)phenylboronic acid pinacol ester.
4-Methoxy-2-(trifluoromethyl)phenylboronic acid pinacol ester was added to the reaction flask and hydrolyzed dropwise with dilute HCl. The solution first produced a precipitate, with the precipitate gradually disappeared, adjust the system pH to 1. To the solution was added NaOH solution with a mass fraction of 25% dropwise to pH 13, stirring 1. h. The solution was partitioned and the organic phase was extracted with 15 . mL of NaOH with a mass fraction of 10%, the aqueous phases were combined, and the base solution was extracted twice with 15 mL of THF, respectively. The pH of the obtained alkaline solution was adjusted with dilute HCl, turbidity was produced at the beginning and flocculent appeared slowly, the pH was adjusted to 5.0. 70 was used to mL THF extraction of the aqueous phase, the organic phase spin-dried and purified to obtain 4-methoxy-2-(trifluoromethyl)phenylboronic acid.
4-METHOXY-2-(TRIFLUOROMETHYL)PHENYLBORONIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-METHOXY-2-(TRIFLUOROMETHYL)PHENYLBORONIC ACID manufacturers
- Product
- 4-METHOXY-2-(TRIFLUOROMETHYL)PHENYLBORONIC ACID 313546-16-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg; 5kg; 100kg
- Release date
- 2019-07-03