2-Trifluoromethylphenylboronic acid
- Product Name
- 2-Trifluoromethylphenylboronic acid
- CAS No.
- 1423-27-4
- Chemical Name
- 2-Trifluoromethylphenylboronic acid
- Synonyms
- 2-(TRIFLUOROMETHYL)PHENYLBORONIC ACID;2-(TRIFLUOROMETHYL)BENZENEBORONIC ACID;AKOS BRN-0242;RARECHEM AH PB 0094;2-(Trifluoromethyl)p;2-Boronobenzotrifluoride;0-Trufluoromethylboronic Acid;2-benzotrifluorideboronic acid;2-Trifluoromethylboronic acid;TrifluoroMethyl)phenylboronic ac
- CBNumber
- CB2226974
- Molecular Formula
- C7H6BF3O2
- Formula Weight
- 189.93
- MOL File
- 1423-27-4.mol
2-Trifluoromethylphenylboronic acid Property
- Melting point:
- 111-114 °C (lit.)
- Boiling point:
- 274.5±50.0 °C(Predicted)
- Density
- 1.36±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- slightly sol. in Methanol
- form
- powder to crystal
- pka
- 8.11±0.58(Predicted)
- color
- White to Almost white
- BRN
- 2974465
- InChI
- InChI=1S/C7H6BF3O2/c9-7(10,11)5-3-1-2-4-6(5)8(12)13/h1-4,12-13H
- InChIKey
- JNSBEPKGFVENFS-UHFFFAOYSA-N
- SMILES
- B(C1=CC=CC=C1C(F)(F)F)(O)O
- CAS DataBase Reference
- 1423-27-4(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 37/39-26-36
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29163990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 445193
- Product name
- 2-(Trifluoromethyl)phenylboronic acid
- Purity
- ≥95.0%
- Packaging
- 1g
- Price
- $51.7
- Updated
- 2023/06/20
- Product number
- 445193
- Product name
- 2-(Trifluoromethyl)phenylboronic acid
- Purity
- ≥95.0%
- Packaging
- 10g
- Price
- $491
- Updated
- 2023/06/20
- Product number
- T1800
- Product name
- 2-(Trifluoromethyl)phenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 1g
- Price
- $30
- Updated
- 2025/07/31
- Product number
- T1800
- Product name
- 2-(Trifluoromethyl)phenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 5g
- Price
- $77
- Updated
- 2025/07/31
- Product number
- T1800
- Product name
- 2-(Trifluoromethyl)phenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 25g
- Price
- $384
- Updated
- 2025/07/31
2-Trifluoromethylphenylboronic acid Chemical Properties,Usage,Production
Chemical Properties
white to light beige crystalline powder
Uses
suzuki reaction
Uses
2-Trifluoromethylphenylboronic Acid is a reagent in the preparation of potent inhibitors of human uric acid transporter 1 (hURAT1).
Uses
2-(Trifluoromethyl)phenylboronic acid can be used as a reactant:
- In Suzuki-coupling reactions to prepare 2-trifluoromethyl aryl or heteroaryl derivatives.
- To synthesize 4-(2-trifluoromethyl)phenylpyrrolo[2,3-d]pyrimidine as a potential antagonist of corticotropin-releasing hormone.
- To prepare 2-nitro-6-(trifluoromethyl)phenylboronic acid by nitration reaction.
Synthesis
6562-41-0
7732-18-5
88-16-4
1423-27-4
To a 250-mL three-necked reaction flask, 2.3 g of magnesium flakes were added and heated to dryness under a nitrogen atmosphere. Subsequently, 0.1 g of iodine, 12.8 g of bis(dimethylamino)chloroborane and 30 mL of tetrahydrofuran were added sequentially. A mixed solution consisting of 2.4 g of 2-chloro(trifluoromethyl)benzene and 20 ml of tetrahydrofuran was added slowly dropwise, and stirring was continued for 30 minutes after completion of the addition. Next, a solution consisting of 12.0 g of 2-chloro(trifluoromethyl)benzene and 100 ml of tetrahydrofuran was added slowly and the temperature of the reaction was maintained at 20-30°C. The addition process was completed in about 2 hours. After completion of the reaction, the mixed solution was cooled to 0°C and 50 ml of saturated ammonium chloride solution was added with continuous stirring for 1 hour. After standing and layering, the aqueous phase was extracted with 70 ml of ethyl acetate. The organic layers were combined, dried with magnesium sulfate and concentrated under reduced pressure. The concentrated residue was dissolved in 80 ml of hot ethyl acetate at 65°C and subsequently cooled to room temperature within 2 hours. 300 ml of n-hexane was added and stirring was continued for 3 h. Filtration gave 7.9 g of white solid 2-trifluoromethylphenylboronic acid in 52% yield.
References
[1] Patent: CN104311587, 2017, B. Location in patent: Paragraph 0068; 0069; 0070
2-Trifluoromethylphenylboronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Trifluoromethylphenylboronic acid manufacturers
- Product
- 2-Trifluoromethylphenylboronic acid 1423-27-4
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 97.4%
- Supply Ability
- 100 tons
- Release date
- 2022-01-26
- Product
- 2-Trifluoromethylphenylboronic acid 1423-27-4
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 2-Trifluoromethylphenylboronic acid 1423-27-4
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09