2-hydroxy-6-methyl-1H-quinolin-4-one
- Product Name
- 2-hydroxy-6-methyl-1H-quinolin-4-one
- CAS No.
- 1677-44-7
- Chemical Name
- 2-hydroxy-6-methyl-1H-quinolin-4-one
- Synonyms
- 6-Methylquinoline-2,4-diol;4-Hydroxy-6-methyl-2-quinolone;6-Methyl-2,4-dihydroxyquinoline;4,6-Dihydroxy-2-methylquinoline;2-hydroxy-6-methyl-1H-quinolin-4-one;4-Hydroxy-6-methyl-1H-quinolin-2-one;2(1H)-Quinolinone, 4-hydroxy-6-methyl-
- CBNumber
- CB41456167
- Molecular Formula
- C10H9NO2
- Formula Weight
- 175.18
- MOL File
- 1677-44-7.mol
2-hydroxy-6-methyl-1H-quinolin-4-one Property
- Melting point:
- 342 ºC
- Boiling point:
- 404.0±45.0 °C(Predicted)
- Density
- 1.313
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 4.50±1.00(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M341805
- Product name
- 6-Methylquinoline-2,4-diol
- Packaging
- 100mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- M341805
- Product name
- 6-Methylquinoline-2,4-diol
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 073413
- Product name
- 6-Methyl-2,4-dihydroxyquinoline
- Purity
- 95+%
- Packaging
- 1g
- Price
- $838
- Updated
- 2021/12/16
- Product number
- 073413
- Product name
- 6-Methyl-2,4-dihydroxyquinoline
- Purity
- 95+%
- Packaging
- 5g
- Price
- $2250
- Updated
- 2021/12/16
- Product number
- W3646
- Product name
- 6-Methyl-2,4-dihydroxyquinoline
- Packaging
- 250mg
- Price
- $298
- Updated
- 2021/12/16
2-hydroxy-6-methyl-1H-quinolin-4-one Chemical Properties,Usage,Production
Synthesis
106-49-0
105-53-3
1677-44-7
In a dry three-necked flask, p-toluidine (5.0 g, 46.7 mmol), diethyl malonate (14 mL, 93.3 mmol) and polyphosphoric acid (22.5 mL, 140 mmol) were added sequentially. The reaction mixture was stirred at 150 °C for 3 hours. Upon completion of the reaction, the reaction system was cooled to room temperature, 500 mL of ice water was slowly added, and the pH was adjusted to 5-6 with alkali. the resulting yellow solid product was collected by filtration. The solid was dissolved in an appropriate amount of sodium hydroxide solution and filtered again to yield 7.5 g of 6-methyl-2,4-dihydroxyquinoline as a yellow solid in 92% yield.
References
[1] Patent: CN107098901, 2017, A. Location in patent: Paragraph 0082; 0083; 0084; 0085
[2] British Journal of Pharmacology, 2015, vol. 172, # 5, p. 1195 - 1221
[3] European Journal of Medicinal Chemistry, 2010, vol. 45, # 10, p. 4467 - 4472
2-hydroxy-6-methyl-1H-quinolin-4-one Preparation Products And Raw materials
Raw materials
Preparation Products
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