3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde
- Product Name
- 3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde
- CAS No.
- 870837-18-6
- Chemical Name
- 3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde
- Synonyms
- 3-Methoxy-4-(4-methyl-1H-imidazol-1-yl);3-methoxy-4-(4-methylimidazole)benzaldehyd;3-methoxy-4-(4-methyl-1-imidazolyl)benzaldehyde;3-METHOXY-4-(4-METHYL-IMIDAZOL-1-YL)-BENZALDEHYDE;3-METHOXY-4-(4-METHYL-1H-IMIDAZOL-1-YL)BENZALDEHYDE;Benzaldehyde, 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)-;3-Methoxy-4-(4-methyl-imidazol-1-yl)-benzaldehyde, CAS 870837-18-6
- CBNumber
- CB41458257
- Molecular Formula
- C12H12N2O2
- Formula Weight
- 216.24
- MOL File
- 870837-18-6.mol
3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde Property
- Boiling point:
- 415.1±40.0 °C(Predicted)
- Density
- 1.16
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 5.43±0.61(Predicted)
- Appearance
- Light yellow to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- X5645
- Product name
- 3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde
- Packaging
- 1g
- Price
- $250
- Updated
- 2021/12/16
- Product number
- 126615
- Product name
- 3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde
- Purity
- >95%
- Packaging
- 1g
- Price
- $576
- Updated
- 2021/12/16
- Product number
- CHM0094137
- Product name
- 3-METHOXY-4-(4-METHYL-1H-IMIDAZOL-1-YL)BENZALDEHYDE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $808.5
- Updated
- 2021/12/16
- Product number
- CHM0094137
- Product name
- 3-METHOXY-4-(4-METHYL-1H-IMIDAZOL-1-YL)BENZALDEHYDE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1328.25
- Updated
- 2021/12/16
- Product number
- X5645
- Product name
- 3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde
- Packaging
- 25g
- Price
- $2548
- Updated
- 2021/12/16
3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde Chemical Properties,Usage,Production
Synthesis
822-36-6
128495-46-5
870837-18-6
General procedure for the synthesis of 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde from 4-methylimidazole and 3-methoxy-4-fluorobenzaldehyde: 4-fluoro-3-methoxybenzaldehyde (85 g, 0.55 mol), 4-methyl-1H-imidazole (90.5 g, 1.1 mol) and cesium carbonate (268.8 g, 0.82 mol) were mixed in dimethylformamide (1.7 L) were mixed and the reaction was stirred at 100 °C for 1 hour. After completion of the reaction, the mixture was cooled to room temperature, filtered, and the filtrate was concentrated under reduced pressure. The concentrated residue was dissolved in water (2 L) and extracted with ethyl acetate (3 x 2 L). The organic layers were combined, washed sequentially with water and brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. Purification by silica gel column chromatography (eluent ratio petroleum ether:ethyl acetate = 2:1) gave a yellow solid. The solid was recrystallized with ethyl acetate (300 mL) to give 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde in white solid form. Yield: 17.8 g, 0.082 mol, 15% yield.1H NMR (300 MHz, CDCl3) δ 2.31 (d, J = 1.0 Hz, 3H), 3.97 (s, 3H), 7.01 (m, 1H), 7.45 (d, J = 7.8 Hz, 1H), 7.54-7.58 (m, 2H), 7.83 (d, J = 1.3 Hz, 1H), 10.01 (s, 1H).
References
[1] Patent: WO2010/100606, 2010, A1. Location in patent: Page/Page column 41-42
[2] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 2, p. 773 - 776
[3] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 13, p. 4083 - 4087
[4] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 9, p. 3140 - 3146
[5] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 9, p. 3140 - 3146
3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde manufacturers
- Product
- 3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde 870837-18-6
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000KG
- Release date
- 2018-08-15