ChemicalBook > CAS DataBase List > CHS-828

CHS-828

Product Name: CHS-828
CAS No.: 200484-11-3
Chemical Name: CHS-828
Synonyms: MX1778;HS-828;GMX 1778;GMX1778, >98%;CHS828;CHS 828;MX1778? CHS-828;GMX1778(CHS-828);CHS-828 (GMX1778);CHS-828, 10 mM in DMSO;2-[6-(4-chlorophenoxy)hexyl]-1-cyano-3-pyridin-4-ylguanidine
CBNumber: CB41463422
Molecular Formula: C19H22ClN5O
Formula Weight: 371.86
MOL File: 200484-11-3.mol

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CHS-828 Property

Melting point:: 166-168°C
Boiling point:: 532.1±58.0 °C(Predicted)
Density: 1.18±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO: soluble20mg/mL, clear
form: powder
pka: 7.36±0.10(Predicted)
color: white to beige
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey: BOIPLTNGIAPDBY-UHFFFAOYSA-N

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Safety

Hazard Codes: T
Risk Statements: 25-36/37/38
Safety Statements: 26-45
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0646
Product name: GMX1778
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $107.35
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML0646
Product name: GMX1778
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $415.15
Updated: 2025/07/31

Cayman Chemical

Product number: 11021
Product name: CHS-828
Purity: ≥98%
Packaging: 5mg
Price: $73
Updated: 2024/03/01

Cayman Chemical

Product number: 11021
Product name: CHS-828
Purity: ≥98%
Packaging: 10mg
Price: $138
Updated: 2024/03/01

Cayman Chemical

Product number: 11021
Product name: CHS-828
Purity: ≥98%
Packaging: 25mg
Price: $324
Updated: 2024/03/01

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CHS-828 Chemical Properties,Usage,Production

Description

CHS-828 is a pyridyl cyanoguanidine anti-tumor agent that has been identified as a competitive inhibitor of Nampt as well as an inhibitor of NF-κB pathway activity. CHS-828 has potent cytotoxic effects in human breast (IC₅₀ = 7.3 nM) and lung cancer (IC₅₀ = 0.5 nM) cells both in vitro and in vivo. In nude mice bearing human tumor xenografts, CHS-828, at 20-50 mg/kg/day, inhibits the growth of MCF-7 breast cancer tumors and induces regression of NYH small cell lung cancer tumors.

Uses

GMX1778 is an anticancer agent that inhibits cellular synthesis of NAD.

Definition

ChEBI: 2-[6-(4-chlorophenoxy)hexyl]-1-cyano-3-pyridin-4-ylguanidine is an aromatic ether.

in vivo

A 4-h iv infusion of NA (120 mg/kg of body weight) did not adversely affect the antitumor activity of a 24-h iv infusion of CHS-828 (GMX1778) at a dose of 150 mg/kg or 650 mg/kg in the NAPRT1-deficient xenograft experiments. CHS-828 (GMX1778) at 650 mg/kg is above the maximum tolerated dose. The administration of NA as a 4-h iv infusion immediately following treatment with 750 mg/kg CHS-828 (GMX1778) reduced the mortality associated with toxic doses of GMX1777^[2].

storage

+4°C

References

[1] UFFE HØGH OLESEN . Anticancer agent CHS-828 inhibits cellular synthesis of NAD[J]. Biochemical and biophysical research communications, 2008, 367 4: Pages 799-804. DOI:10.1016/j.bbrc.2008.01.019
[2] SAADIA B HASSAN. CHS 828 kill tumour cells by inhibiting the nuclear factor-kappaB translocation but unlikely through down-regulation of proteasome.[J]. Anticancer research, 2006, 26 6B: 4431-4436.
[3] P J HJARNAA. CHS 828, a novel pyridyl cyanoguanidine with potent antitumor activity in vitro and in vivo.[J]. Cancer research, 1999, 59 22: 5751-5757.
[4] DAVID CERNA. Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) activity by small molecule GMX1778 regulates reactive oxygen species (ROS)-mediated cytotoxicity in a p53- and nicotinic acid phosphoribosyltransferase1 (NAPRT1)-dependent manner.[J]. The Journal of Biological Chemistry, 2012: 22408-22417. DOI:10.1074/jbc.m112.357301

CHS-828 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from CHS-828 manufacturers

Career Henan Chemical Co

Product: CHS-828 200484-11-3
Price: US $1.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 95%~99%
Supply Ability: per week:100kg
Release date: 2019-09-05

200484-11-3, CHS-828Related Search:

CYCLOPAMINE S-Trityl-L-cysteine AG 490 (+)-Camptothecin N-ACETYLLACTOSAMINE

GMX 1778

N-[6-(4-Chlorophenoxy)hexyl]-N'-cyano-N''-4-pyridinylguanidine

1-(6-(4-chlorophenoxy)hexyl)-2-cyano-3-(pyridin-4-yl)guanidine

GMX1778(CHS-828)

2-[6-(4-chlorophenoxy)hexyl]-1-cyano-3-pyridin-4-ylguanidine

CHS828;CHS 828

GMX1778, >98%

HS-828

MX1778

Guanidine, N-[6-(4-chlorophenoxy)hexyl]-N'-cyano-N''-4-pyridinyl-

1-[6-(4-Chlorophenoxy)hexyl]-3-cyano-2-pyridin-4-ylguanidine

Nicotinamide phosphoribosyl transferase,NAMPT,inhibit,PBEF,Visfatin,Apoptosis,Inhibitor,Pre-B cell colony enhancing factor,CHS-828,GMX-1778,CHS828,GMX 1778

MX1778? CHS-828

CHS-828, 10 mM in DMSO

CHS-828 (GMX1778)

200484-11-3

Inhibitors