ChemicalBook > CAS DataBase List > CHS-828

CHS-828

Product Name
CHS-828
CAS No.
200484-11-3
Chemical Name
CHS-828
Synonyms
MX1778;HS-828;GMX 1778;GMX1778, >98%;CHS828;CHS 828;MX1778? CHS-828;GMX1778(CHS-828);2-[6-(4-chlorophenoxy)hexyl]-1-cyano-3-pyridin-4-ylguanidine;1-[6-(4-Chlorophenoxy)hexyl]-3-cyano-2-pyridin-4-ylguanidine;1-(6-(4-chlorophenoxy)hexyl)-2-cyano-3-(pyridin-4-yl)guanidine
CBNumber
CB41463422
Molecular Formula
C19H22ClN5O
Formula Weight
371.86
MOL File
200484-11-3.mol
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CHS-828 Property

Melting point:
166-168°C
Boiling point:
532.1±58.0 °C(Predicted)
Density 
1.18±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
DMSO: soluble20mg/mL, clear
form 
powder
pka
7.36±0.10(Predicted)
color 
white to beige
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey
BOIPLTNGIAPDBY-UHFFFAOYSA-N
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Safety

Hazard Codes 
T
Risk Statements 
25-36/37/38
Safety Statements 
26-45
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0646
Product name
GMX1778
Purity
≥98% (HPLC)
Packaging
5mg
Price
$110
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0646
Product name
GMX1778
Purity
≥98% (HPLC)
Packaging
25mg
Price
$425
Updated
2024/03/01
Cayman Chemical
Product number
11021
Product name
CHS-828
Purity
≥98%
Packaging
5mg
Price
$73
Updated
2024/03/01
Cayman Chemical
Product number
11021
Product name
CHS-828
Purity
≥98%
Packaging
10mg
Price
$138
Updated
2024/03/01
Cayman Chemical
Product number
11021
Product name
CHS-828
Purity
≥98%
Packaging
25mg
Price
$324
Updated
2024/03/01
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CHS-828 Chemical Properties,Usage,Production

Description

CHS-828 is a pyridyl cyanoguanidine anti-tumor agent that has been identified as a competitive inhibitor of Nampt as well as an inhibitor of NF-κB pathway activity. CHS-828 has potent cytotoxic effects in human breast (IC50 = 7.3 nM) and lung cancer (IC50 = 0.5 nM) cells both in vitro and in vivo. In nude mice bearing human tumor xenografts, CHS-828, at 20-50 mg/kg/day, inhibits the growth of MCF-7 breast cancer tumors and induces regression of NYH small cell lung cancer tumors.

Uses

GMX1778 is an anticancer agent that inhibits cellular synthesis of NAD.

Definition

ChEBI: 2-[6-(4-chlorophenoxy)hexyl]-1-cyano-3-pyridin-4-ylguanidine is an aromatic ether.

storage

+4°C

References

1) Olesen?et al.?(2008),?Anticancer agent CHS-828 inhibits cellular synthesis of NAD; Biochem. Biophys. Res. Commun.?376?799 2) Hassan?et al. (2006),?CHS 828 kill tumor cells by inhibiting the nuclear factor-kappaB translocation but unlikely through down-regulation of proteasome; Anticancer Res.?26?4431 3) Hjarnaa?et al.?(1999),?CHS 828, a novel pyridyl cyanoguanidine with potent antitumor activity in vitro and in vivo; Cancer Res.?59?5751 4) Cerna?et al.?(2012)?Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) activity by small molecule GMX1778 regulates reactive oxygen species (ROS)-mediated cytotoxicity in a p53- and nicotinic acid phosphoribosyltransferase1 (NAPRT1)-dependent manner; J. Biol. Chem.?287?22408

CHS-828 Preparation Products And Raw materials

Raw materials

Preparation Products

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CHS-828 Suppliers

China 81 India 2 United States 16 Global 99
Shanghai Boyle Chemical Co., Ltd.
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View Lastest Price from CHS-828 manufacturers

Career Henan Chemical Co
Product
CHS-828 200484-11-3
Price
US $1.00/ASSAYS
Min. Order
1ASSAYS
Purity
95%~99%
Supply Ability
per week:100kg
Release date
2019-09-05

200484-11-3, CHS-828Related Search:

CYCLOPAMINE S-Trityl-L-cysteine AG 490 (+)-Camptothecin N-ACETYLLACTOSAMINE

  • GMX 1778
  • N-[6-(4-Chlorophenoxy)hexyl]-N'-cyano-N''-4-pyridinylguanidine
  • 1-(6-(4-chlorophenoxy)hexyl)-2-cyano-3-(pyridin-4-yl)guanidine
  • GMX1778(CHS-828)
  • 2-[6-(4-chlorophenoxy)hexyl]-1-cyano-3-pyridin-4-ylguanidine
  • CHS828;CHS 828
  • GMX1778, >98%
  • HS-828
  • MX1778
  • Guanidine, N-[6-(4-chlorophenoxy)hexyl]-N'-cyano-N''-4-pyridinyl-
  • 1-[6-(4-Chlorophenoxy)hexyl]-3-cyano-2-pyridin-4-ylguanidine
  • Nicotinamide phosphoribosyl transferase,NAMPT,inhibit,PBEF,Visfatin,Apoptosis,Inhibitor,Pre-B cell colony enhancing factor,CHS-828,GMX-1778,CHS828,GMX 1778
  • Guanidine, N-[6-(4-chlorophenoxy)hexyl]-N'-cyano-N''-4-pyridinyl-
  • MX1778? CHS-828
  • 200484-11-3
  • Inhibitors