Guaiacol glycidyl ether
- Product Name
- Guaiacol glycidyl ether
- CAS No.
- 2210-74-4
- Chemical Name
- Guaiacol glycidyl ether
- Synonyms
- 2-[(2-Methoxyphenoxy)methyl]oxirane;Ranolazine USP Related Compound A;1-(2-Methoxyphenoxy) -2,3-Epoxy Propane;RZ-3;RZ-1;NSC 112256;NSC 133442;guajacol-glycidaether;GUAIACOL GLYCIDYL ETHER;Ranolazine Intermediate
- CBNumber
- CB4146647
- Molecular Formula
- C10H12O3
- Formula Weight
- 180.2
- MOL File
- 2210-74-4.mol
Guaiacol glycidyl ether Property
- Melting point:
- 33-36°C
- Boiling point:
- 152-158℃
- Density
- 1.142±0.06 g/cm3(Predicted)
- RTECS
- TZ3550000
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- soluble in Chloroform, Methanol
- form
- Solid
- color
- Off-white
- Water Solubility
- 4.21g/L at 20℃
- InChI
- InChI=1S/C10H12O3/c1-11-9-4-2-3-5-10(9)13-7-8-6-12-8/h2-5,8H,6-7H2,1H3
- InChIKey
- RJNVSQLNEALZLC-UHFFFAOYSA-N
- SMILES
- O1CC1COC1=CC=CC=C1OC
- LogP
- 1.54 at 25℃
- CAS DataBase Reference
- 2210-74-4(CAS DataBase Reference)
Safety
- HS Code
- 29109000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H317May cause an allergic skin reaction
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- G0416
- Product name
- Glycidyl 2-Methoxyphenyl Ether
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $49
- Updated
- 2025/07/31
- Product number
- G0416
- Product name
- Glycidyl 2-Methoxyphenyl Ether
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $196
- Updated
- 2025/07/31
- Product number
- M265700
- Product name
- 2-[(2-Methoxyphenoxy)methyl]oxirane
- Packaging
- 2g
- Price
- $145
- Updated
- 2021/12/16
- Product number
- J54647
- Product name
- 2-[(2-Methoxyphenoxy)methyl]oxirane
- Packaging
- 1g
- Price
- $10
- Updated
- 2021/12/16
- Product number
- J54647
- Product name
- 2-[(2-Methoxyphenoxy)methyl]oxirane
- Packaging
- 100g
- Price
- $150
- Updated
- 2021/12/16
Guaiacol glycidyl ether Chemical Properties,Usage,Production
Chemical Properties
White Crystalline Solid
Uses
Ranolazine intermediate
Flammability and Explosibility
Non flammable
Synthesis
90-05-1
106-89-8
2210-74-4
To a round-bottomed flask was added 2.5 L of water followed by 80 g of sodium hydroxide and stirred until completely dissolved. Next, 500 g of guaiacol and 1.12 kg of 1-chloro-2,3-epoxypropane were added and the reaction was continuously stirred at 25-35°C for 5-6 hours. After completion of the reaction, the organic layer was separated. To the separated obtained epichlorohydrin layer was added 160 g of sodium hydroxide dissolved in 2.5 L of water and stirring was continued at 25-30 °C for 3-4 hours. The organic layer was again separated and the organic layer was washed with 150 g of sodium hydroxide dissolved in 1.5 L of water. Subsequently, the product layer was distilled at 90°C and 600-700 mmHg under vacuum to recover excess epichlorohydrin, resulting in 650-680 g of oily product. To this crude product was added 3.0 L of isopropanol, cooled to 0 °C and filtered to give 1-(2-methoxyphenoxy)-2,3-epoxypropane (3). Yield: 80%; purity >98%.
References
[1] Organic Process Research and Development, 2012, vol. 16, # 10, p. 1660 - 1664
[2] Medicinal Chemistry Research, 2004, vol. 13, # 8-9, p. 631 - 642
[3] Synthetic Communications, 1994, vol. 24, # 6, p. 833 - 838
[4] Tetrahedron, 2006, vol. 62, # 47, p. 10968 - 10979
[5] Angewandte Chemie - International Edition, 2014, vol. 53, # 26, p. 6641 - 6644
Guaiacol glycidyl ether Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Guaiacol glycidyl ether manufacturers
- Product
- Guaiacol glycidyl ether 2210-74-4
- Price
- US $30.00-10.00/KG
- Min. Order
- 50KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-11-05
- Product
- Guaiacol glycidyl ether 2210-74-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-19
- Product
- Guaiacol glycidyl ether 2210-74-4
- Price
- US $10.00-7.00/kg
- Min. Order
- 1kg
- Purity
- 99.9%
- Supply Ability
- 20ton
- Release date
- 2024-06-06