Guaiacol glycidyl ether

Product Name: Guaiacol glycidyl ether
CAS No.: 2210-74-4
Chemical Name: Guaiacol glycidyl ether
Synonyms: 2-[(2-Methoxyphenoxy)methyl]oxirane;Ranolazine USP Related Compound A;1-(2-Methoxyphenoxy) -2,3-Epoxy Propane;RZ-3;RZ-1;NSC 112256;NSC 133442;guajacol-glycidaether;GUAIACOL GLYCIDYL ETHER;Ranolazine Intermediate
CBNumber: CB4146647
Molecular Formula: C10H12O3
Formula Weight: 180.2
MOL File: 2210-74-4.mol

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Guaiacol glycidyl ether Property

Melting point:: 33-36°C
Boiling point:: 152-158℃
Density: 1.142±0.06 g/cm3(Predicted)
RTECS: TZ3550000
storage temp.: Sealed in dry,Room Temperature
solubility: soluble in Chloroform, Methanol
form: Solid
color: Off-white
Water Solubility: 4.21g/L at 20℃
Major Application: pharmaceutical
InChI: InChI=1S/C10H12O3/c1-11-9-4-2-3-5-10(9)13-7-8-6-12-8/h2-5,8H,6-7H2,1H3
InChIKey: RJNVSQLNEALZLC-UHFFFAOYSA-N
SMILES: O1CC1COC1=CC=CC=C1OC
LogP: 1.54 at 25℃
CAS DataBase Reference: 2210-74-4(CAS DataBase Reference)

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Safety

WGK Germany: WGK 3
HS Code: 29109000
Storage Class: 11 - Combustible Solids
Hazard Classifications: Skin Irrit. 2
Skin Sens. 1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

TCI Chemical

Product number: G0416
Product name: Glycidyl 2-Methoxyphenyl Ether
Purity: >98.0%(GC)
Packaging: 5g
Price: $49
Updated: 2025/07/31

TCI Chemical

Product number: G0416
Product name: Glycidyl 2-Methoxyphenyl Ether
Purity: >98.0%(GC)
Packaging: 25g
Price: $196
Updated: 2025/07/31

TRC

Product number: M265700
Product name: 2-[(2-Methoxyphenoxy)methyl]oxirane
Packaging: 2g
Price: $145
Updated: 2021/12/16

AK Scientific

Product number: J54647
Product name: 2-[(2-Methoxyphenoxy)methyl]oxirane
Packaging: 100g
Price: $150
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 11683
Product name: 2-[(2-Methoxyphenoxy)methyl]oxirane
Packaging: 5G
Price: $1960
Updated: 2021/12/16

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Guaiacol glycidyl ether Chemical Properties,Usage,Production

Chemical Properties

White Crystalline Solid

Uses

Ranolazine intermediate

Flammability and Explosibility

Non flammable

Synthesis

90-05-1

106-89-8

2210-74-4

To a round-bottomed flask was added 2.5 L of water followed by 80 g of sodium hydroxide and stirred until completely dissolved. Next, 500 g of guaiacol and 1.12 kg of 1-chloro-2,3-epoxypropane were added and the reaction was continuously stirred at 25-35°C for 5-6 hours. After completion of the reaction, the organic layer was separated. To the separated obtained epichlorohydrin layer was added 160 g of sodium hydroxide dissolved in 2.5 L of water and stirring was continued at 25-30 °C for 3-4 hours. The organic layer was again separated and the organic layer was washed with 150 g of sodium hydroxide dissolved in 1.5 L of water. Subsequently, the product layer was distilled at 90°C and 600-700 mmHg under vacuum to recover excess epichlorohydrin, resulting in 650-680 g of oily product. To this crude product was added 3.0 L of isopropanol, cooled to 0 °C and filtered to give 1-(2-methoxyphenoxy)-2,3-epoxypropane (3). Yield: 80%; purity >98%.

References

[1] Organic Process Research and Development, 2012, vol. 16, # 10, p. 1660 - 1664
[2] Medicinal Chemistry Research, 2004, vol. 13, # 8-9, p. 631 - 642
[3] Synthetic Communications, 1994, vol. 24, # 6, p. 833 - 838
[4] Tetrahedron, 2006, vol. 62, # 47, p. 10968 - 10979
[5] Angewandte Chemie - International Edition, 2014, vol. 53, # 26, p. 6641 - 6644

Guaiacol glycidyl ether Preparation Products And Raw materials

Raw materials

Guaiacol Epichlorohydrin

Preparation Products

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Guaiacol glycidyl ether Suppliers

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View Lastest Price from Guaiacol glycidyl ether manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Guaiacol glycidyl ether 2210-74-4
Price: US $0.10/KG
Min. Order: 0.1KG
Purity: 98%HPLC
Supply Ability: 200tons
Release date: 2025-12-15

Hebei Chuanghai Biotechnology Co., Ltd

Product: Guaiacol glycidyl ether 2210-74-4
Price: US $30.00-10.00/KG
Min. Order: 50KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-11-05

Henan Aochuang Chemical Co.,Ltd.

Product: Guaiacol glycidyl ether 2210-74-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-19

2210-74-4, Guaiacol glycidyl etherRelated Search:

BENZYL GLYCIDYL ETHER Isobutylene oxide Glycidyl acrylate Butyl glycidyl ether Ethylbenzene Methyl acetate Ethylene glycol diglycidyl ether PETROLEUM ETHER Allyl glycidyl ether Bensulfuron methyl Methylparaben 2-Methoxy-4-methylphenol 1,2,3-PROPANETRIOL GLYCIDYL ETHER (R)-Styrene oxide Propylene oxide DIGLYCIDYL ETHER Guaiacol Thiophanate-methyl

GUAIACOL GLYCIDYL ETHER

[(2-methoxyphenoxy)methyl]oxirane

3-(O-METHOXYPHENOXY)-1,2-EPOXYPROPANE

O-METHOXY PHENYL CYCLOXYPROPYL ETHER

1,2-epoxy-3-(o-methoxyphenoxy)-propan

1,2-epoxy-3-(o-methoxyphenoxy)propane

3-(2-Methoxphenoxy)-1,2-epoxypropane

Oxirane,2-[(2-Methoxyphenoxy)Methyl]-

Guaiacol glycidyl ether[(2-et hoxyhenoxy)Methyl]oxirane

Oxirane,2-[(2-Methoxyphenoxy)Methyl]- CAS NO.: 2210-74-4

1-(2-Methoxyphenoxy)Methyl Oxirane

[(2-Methoxyphenoxy)Methyl]oxirane (GGE)

pharMaceutical internediate

Ranolazine Related CoMpound A

Guaiacol glycidyl ether [(2-Methoxyphenoxy)methyl]oxirane

Ranolazine Related Compound A (50 mg) ((+/-)-2-[(2-methoxyphenoxy)methyl]oxirane)

1-(2-METHOXYPHENOXY)-2,3-EPXOYPROPANE

guajacol-glycidaether

[(o-methoxyphenoxy)methyl]oxirane

1-(2-Mthoxyphenoxy)methyl oxirane

RZ-3

N-2,6-dimethylphenyl-2-chloro acetamide

RZ-1

1,2-Epoxy-3-(2-Methoxyphenoxy)Propane

3-(Dimethoxyphenoxy)-1,2-Propylene Epoxide

1-[(2-methoxyphenoxy)methyl]oxirane oppure guaiacol glycidyl ether

2-((2-METHOXYPHENOXY)METHYL)OXIRANE:95+%

1-(2-Methoxyphenoxy) -2,3-Epoxy Propane

1-(2,3-Epoxypropoxy)-2-methoxybenzene

2-[(2-Methoxyphenoxy)methyl]oxirane

Glycidyl 2-Methoxyphenyl Ether

NSC 112256

NSC 133442

1-(Glycidyloxy)-2-methoxybenzene

1-(Oxiranylmethyloxy)-2-methoxybenzene

2-[(o-Methoxyphenoxy)methyl]oxirane

Ranolazine Intermediate

3-(2-Methoxyphenoxy)-1,2-epoxypropane

Guaiacol glycidyl ether（GGE）

Glycidyl2-MethoxyphenylEther&gt

Glycidyl2-methoxyphenylether,98%

Glycidyl Guaiacol Ether

Guaiacol glycidyl ether ISO 9001：2015 REACH

Reynolds azine impurity reference substance

Ranolazine USP Related Compound A

Guaifenesin Impurity-1/Ranolazine RC A

2-(2-METHOXYPHNOXY)MEHYL OXIRANE

Ranolazine Related Compound A ((+/-)-2-[(2-methoxyphenoxy)methyl]oxirane) (1598755)

1-methoxy-2-(oxiranylmethoxy)benzene

2-[2-Methoxyphenoxy)methyl]Oxirane (MET)

2-{[(2-methoxyphenyl)oxy]methyl}oxirane

Ranolazine Related Compound 4 1-(2-methoxyphenoxy)-2,3- epoxy propane

Ranolazine Related Compound A 2-[(2-Methoxyphenoxy)methyl]oxirane

Ranolazine Impurity 27 (Ranolazine USP Related Compound A)

[(2-Methoxyphenoxy)Methyl]Oxirane, 10 mM in DMSO

2210-74-4

210-74-4

INTERMEDIATESOFRANOLAZINE