2,2-Dimethyltetrahydro-2H-pyran-4-carboxylic acid
- Product Name
- 2,2-Dimethyltetrahydro-2H-pyran-4-carboxylic acid
- CAS No.
- 52916-16-2
- Chemical Name
- 2,2-Dimethyltetrahydro-2H-pyran-4-carboxylic acid
- Synonyms
- 2,2-dimethyloxane-4-carboxylic acid;2,2-dimethyl-4-tetrahydropyrancarboxylic acid;2,2-dimethyloxane-4-carboxylic acid - [D86899];2,2-Dimethyltetrahydro-2H-pyran-4-carboxylic acid;tetrahydro-2,2-dimethyl-2H-pyran-4-carboxylic acid;2H-Pyran-4-carboxylic acid, tetrahydro-2,2-dimethyl-;2,2-dimethyltetrahydro-2H-pyran-4-carboxylic acid(SALTDATA: FREE)
- CBNumber
- CB41482128
- Molecular Formula
- C8H14O3
- Formula Weight
- 158.2
- MOL File
- 52916-16-2.mol
2,2-Dimethyltetrahydro-2H-pyran-4-carboxylic acid Property
- Melting point:
- 102 °C
- Boiling point:
- 261.8±33.0 °C(Predicted)
- Density
- 1.067±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 4.45±0.40(Predicted)
- Appearance
- Off-white to light yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D457838
- Product name
- 2,2-dimethyltetrahydro-2H-pyran-4-carboxylicacid
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FD136168
- Product name
- 2,2-Dimethyltetrahydro-2H-pyran-4-carboxylic acid
- Packaging
- 100mg
- Price
- $72
- Updated
- 2021/12/16
- Product number
- FD136168
- Product name
- 2,2-Dimethyltetrahydro-2H-pyran-4-carboxylic acid
- Packaging
- 250mg
- Price
- $145
- Updated
- 2021/12/16
- Product number
- FD136168
- Product name
- 2,2-Dimethyltetrahydro-2H-pyran-4-carboxylic acid
- Packaging
- 500mg
- Price
- $250
- Updated
- 2021/12/16
- Product number
- 159697
- Product name
- 2,2-Dimethyltetrahydro-2H-pyran-4-carboxylic acid
- Packaging
- 0.500g
- Price
- $400
- Updated
- 2021/12/16
2,2-Dimethyltetrahydro-2H-pyran-4-carboxylic acid Chemical Properties,Usage,Production
Synthesis
60549-63-5
52916-16-2
The reaction was carried out overnight at reflux in 2N KOH aqueous solution using 2,2-dimethyltetrahydro-2H-pyran-4-carbonitrile (900 mg, 6.47 mmol) as raw material. After completion of the reaction, the reaction mixture was diluted with water and extracted with ethyl acetate and the organic phase was discarded. The aqueous phase was acidified to pH < 7 with 2N HCl solution and subsequently extracted twice with ethyl acetate. The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated in vacuum to give the crude product 2,2-dimethyltetrahydro-2H-pyran-4-carboxylic acid (889 mg, 5.62 mmol, 87% yield). The product was characterized by 1H-NMR (400 MHz, DMSO-d6): δ[ppm] 1.13 (s, 3H), 1.14 (s, 3H), 1.26-1.45 (m, 2H), 1.65-1.73 (m, 2H), 2.59 (tt, 1H), 3.54 (td, 1H), 3.60 (ddd, 1H), 12.20 (s, 1H).
References
[1] Patent: WO2016/198374, 2016, A1. Location in patent: Page/Page column 131-132
2,2-Dimethyltetrahydro-2H-pyran-4-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,2-Dimethyltetrahydro-2H-pyran-4-carboxylic acid manufacturers
- Product
- 2,2-Dimethyltetrahydro-2H-pyran-4-carboxylic acid 52916-16-2
- Price
- US $1.60-6.60/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-19
- Product
- 2,2-Dimethyltetrahydro-2H-pyran-4-carboxylic acid 52916-16-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1kg-1000kg
- Release date
- 2020-01-03