ChemicalBook > CAS DataBase List > 2,2-Dimethyltetrahydro-2H-pyran-4-carboxylic acid

2,2-Dimethyltetrahydro-2H-pyran-4-carboxylic acid

Product Name
2,2-Dimethyltetrahydro-2H-pyran-4-carboxylic acid
CAS No.
52916-16-2
Chemical Name
2,2-Dimethyltetrahydro-2H-pyran-4-carboxylic acid
Synonyms
2,2-dimethyloxane-4-carboxylic acid;2,2-dimethyl-4-tetrahydropyrancarboxylic acid;2,2-dimethyloxane-4-carboxylic acid - [D86899];2,2-Dimethyltetrahydro-2H-pyran-4-carboxylic acid;tetrahydro-2,2-dimethyl-2H-pyran-4-carboxylic acid;2H-Pyran-4-carboxylic acid, tetrahydro-2,2-dimethyl-;2,2-dimethyltetrahydro-2H-pyran-4-carboxylic acid(SALTDATA: FREE)
CBNumber
CB41482128
Molecular Formula
C8H14O3
Formula Weight
158.2
MOL File
52916-16-2.mol
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2,2-Dimethyltetrahydro-2H-pyran-4-carboxylic acid Property

Melting point:
102 °C
Boiling point:
261.8±33.0 °C(Predicted)
Density 
1.067±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
4.45±0.40(Predicted)
Appearance
Off-white to light yellow Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
D457838
Product name
2,2-dimethyltetrahydro-2H-pyran-4-carboxylicacid
Packaging
10mg
Price
$45
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD136168
Product name
2,2-Dimethyltetrahydro-2H-pyran-4-carboxylic acid
Packaging
100mg
Price
$72
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD136168
Product name
2,2-Dimethyltetrahydro-2H-pyran-4-carboxylic acid
Packaging
250mg
Price
$145
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD136168
Product name
2,2-Dimethyltetrahydro-2H-pyran-4-carboxylic acid
Packaging
500mg
Price
$250
Updated
2021/12/16
Matrix Scientific
Product number
159697
Product name
2,2-Dimethyltetrahydro-2H-pyran-4-carboxylic acid
Packaging
0.500g
Price
$400
Updated
2021/12/16
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2,2-Dimethyltetrahydro-2H-pyran-4-carboxylic acid Chemical Properties,Usage,Production

Synthesis

60549-63-5

52916-16-2

The reaction was carried out overnight at reflux in 2N KOH aqueous solution using 2,2-dimethyltetrahydro-2H-pyran-4-carbonitrile (900 mg, 6.47 mmol) as raw material. After completion of the reaction, the reaction mixture was diluted with water and extracted with ethyl acetate and the organic phase was discarded. The aqueous phase was acidified to pH < 7 with 2N HCl solution and subsequently extracted twice with ethyl acetate. The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated in vacuum to give the crude product 2,2-dimethyltetrahydro-2H-pyran-4-carboxylic acid (889 mg, 5.62 mmol, 87% yield). The product was characterized by 1H-NMR (400 MHz, DMSO-d6): δ[ppm] 1.13 (s, 3H), 1.14 (s, 3H), 1.26-1.45 (m, 2H), 1.65-1.73 (m, 2H), 2.59 (tt, 1H), 3.54 (td, 1H), 3.60 (ddd, 1H), 12.20 (s, 1H).

References

[1] Patent: WO2016/198374, 2016, A1. Location in patent: Page/Page column 131-132

2,2-Dimethyltetrahydro-2H-pyran-4-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2,2-Dimethyltetrahydro-2H-pyran-4-carboxylic acid manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
2,2-Dimethyltetrahydro-2H-pyran-4-carboxylic acid 52916-16-2
Price
US $1.60-6.60/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-06-19
Career Henan Chemical Co
Product
2,2-Dimethyltetrahydro-2H-pyran-4-carboxylic acid 52916-16-2
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1kg-1000kg
Release date
2020-01-03

52916-16-2, 2,2-Dimethyltetrahydro-2H-pyran-4-carboxylic acidRelated Search:

Centchroman N,N-Dimethylformamide Dimethyl sulfoxide Poly(dimethylsiloxane) Tetrahydro-4H-pyran-4-one Tetrahydropyran-4-carbaldehyde Tetrahydro-2H-pyran-4-carboxylic acid CARBOXYLIC ACID 2,2-DIMETHYL-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID METHYL ESTER 2,2-DIMETHYL-TETRAHYDRO-PYRAN-4-CARBALDEHYDE 2,2-DIMETHYL-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID ETHYL ESTER 2,2-Dimethyltetrahydro-2H-pyran-4-carboxylic acid

  • tetrahydro-2,2-dimethyl-2H-pyran-4-carboxylic acid
  • 2,2-Dimethyltetrahydro-2H-pyran-4-carboxylic acid
  • 2,2-dimethyltetrahydro-2H-pyran-4-carboxylic acid(SALTDATA: FREE)
  • 2,2-dimethyl-4-tetrahydropyrancarboxylic acid
  • 2,2-dimethyloxane-4-carboxylic acid
  • 2H-Pyran-4-carboxylic acid, tetrahydro-2,2-dimethyl-
  • 2,2-dimethyloxane-4-carboxylic acid - [D86899]
  • 52916-16-2