1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE

Product Name: 1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE
CAS No.: 54605-72-0
Chemical Name: 1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE
Synonyms: AKOS PAO-0282;AKOS BBS-00006876;TIMTEC-BB SBB010539;CHEMBRDG-BB 4301500;1-phenypyrazole-4-carbaldehyde;1-phenylpyrazole-4-carbaldehyde;1-phenyl-4-pyrazolecarboxaldehyde;1-Phenyl-1H-pyrazol-4-carbaldehyd;1-Phenylpyrazole-4-carboxaldehyde;1-Phenyl-1H-pyrazol-4-carbaldehyde
CBNumber: CB4148656
Molecular Formula: C10H8N2O
Formula Weight: 172.18
MOL File: 54605-72-0.mol

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1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE Property

Melting point:: 84-88 °C
Boiling point:: 312.7±15.0 °C(Predicted)
Density: 1.15±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: soluble in Toluene
pka: -2.57±0.10(Predicted)
form: Solid
color: Pale yellow
Sensitive: Moisture & Light Sensitive
InChI: InChI=1S/C10H8N2O/c13-8-9-6-11-12(7-9)10-4-2-1-3-5-10/h1-8H
InChIKey: PHVRLPFVPVKYOI-UHFFFAOYSA-N
SMILES: N1(C2=CC=CC=C2)C=C(C=O)C=N1
CAS DataBase Reference: 54605-72-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38-20/21/22
Safety Statements: 26-37/39-36/37-3/7
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29339900
Storage Class: 11 - Combustible Solids
Hazard Classifications: Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CBR01104
Product name: 1-Phenyl-1H-pyrazole-4-carboxaldehyde
Purity: Aldrich
Packaging: 1g
Price: $128
Updated: 2025/07/31

Sigma-Aldrich

Product number: 732451
Product name: 1-Phenyl-1H-pyrazole-4-carboxaldehyde
Packaging: 250mg
Price: $115
Updated: 2023/01/07

TCI Chemical

Product number: P2473
Product name: 1-Phenyl-1H-pyrazole-4-carboxaldehyde
Packaging: 1G
Price: $93
Updated: 2025/07/31

TCI Chemical

Product number: P2473
Product name: 1-Phenyl-1H-pyrazole-4-carboxaldehyde
Packaging: 5G
Price: $339
Updated: 2025/07/31

TRC

Product number: P336230
Product name: 1-Phenylpyrazole-4-carboxaldehyde
Packaging: 100mg
Price: $65
Updated: 2021/12/16

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1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE Chemical Properties,Usage,Production

Chemical Properties

White crystal

Uses

1-Phenylpyrazole-4-carboxaldehyde is used to synthesize phenyl-pyrazolyl acrylic acid benzylidene carbohydrazide derivatives with antichagasic activities. It is also used to prepare ORL1 receptor antagonists.

Synthesis

1126-00-7

68-12-2

54605-72-0

1) Add 7.3 g (0.1 mmol) of N,N-dimethylformamide (DMF) to a 250 mL three-necked flask and cool in an ice water bath with stirring. 15.4 g (0.1 mmol) of phosphorus triclosan was slowly added dropwise and stirring was continued for 1 hour after completion of the drop. Subsequently, 2.88 g (0.02 mmol) of 1-phenylpyrazole was added and the reaction was heated to 100°C and refluxed for 3-6 h. The reaction was monitored by TLC.2) Upon completion of the reaction, the reaction mixture was poured into ice-water and the pH was adjusted to neutral with sodium carbonate solution. It was extracted with ethyl acetate (3 x 50 mL), and the combined organic phases were washed with 50 mL of saturated brine.3) The organic phase was purified by column chromatography (the eluent was a solvent mixture of ethyl acetate and petroleum ether (60-90°C), 1:5, v/v/v), and was concentrated under reduced pressure to give 3.10 g of the white solid product, 1-phenyl-1H-pyrazole-4-carbaldehyde, in 90.0% yield.

References

[1] Patent: CN107964007, 2018, A. Location in patent: Paragraph 0498
[2] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 1, p. 295 - 302
[3] Journal of Heterocyclic Chemistry, 1993, vol. 30, # 4, p. 957 - 960
[4] Patent: US2006/34786, 2006, A1. Location in patent: Page/Page column 62
[5] Synthetic Communications, 1998, vol. 28, # 7, p. 1299 - 1321

1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE Preparation Products And Raw materials

Raw materials

Ethanol N,N-Dimethylformamide Phosphorus oxitrichloride Dichloromethane 1,1,3,3-Tetramethoxypropane Phenylhydrazine

Preparation Products

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1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE Suppliers

China 93 Germany 3 Hungary 1 India 5 Japan 1 Russia 2 Ukraine 3 United Kingdom 4 United States 26 Global 138

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View Lastest Price from 1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE manufacturers

Career Henan Chemical Co

Product: 1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE 54605-72-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 150KG
Release date: 2019-07-09

54605-72-0, 1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDERelated Search:

4-ACETYL-5-METHYL-1-PHENYLPYRAZOLE 5-AMINO-1-PHENYLPYRAZOLE-4-CARBOXAMIDE 1-PHENYL-5-PROPYL-1H-PYRAZOLE-4-CARBOXYLIC ACID 5-AMINO-4-CARBETHOXY-1-PHENYLPYRAZOLE 1-(4-CHLOROPHENYL)-5-PROPYL-1H-PYRAZOLE-4-CARBOXYLIC ACID 1-PHENYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOHYDRAZIDE 5-METHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID 2-(4-CHLOROPHENYL)-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBONYL CHLORIDE ETHYL 5-METHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLATE 3,5-DIMETHYL-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE 1-PHENYL-5-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBONYL CHLORIDE ETHYL 2-PHENYL-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE 5-METHYL-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE 3-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE 3-P-TOLYL-1H-PYRAZOLE-4-CARBOXALDEHYDE 1-PHENYL-1H-PYRAZOLE-5-CARBALDEHYDE 1-(3-Fluoro-phenyl)-1H-pyrazole-4-carbaldehyde 2-METHYL-5-PHENYL-2H-PYRAZOLE-3-CARBALDEHYDE

TIMTEC-BB SBB010539

1-PHENYL-1H-PYRAZOLE-4-CARBOXALDEHYDE

1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE

AKOS BBS-00006876

1-Phenyl-1H-pyrazole-4-carboxaldehyde 98%

1-Phenyl-1H-pyrazol-4-carbaldehyd

1H-Pyrazole-4-carboxaldehyde, 1-phenyl-

1-phenyl-4-pyrazolecarboxaldehyde

1-phenylpyrazole-4-carbaldehyde

1-Phenyl-1H-pyrazole-4-carbaldehyde ,98%

AKOS PAO-0282

CHEMBRDG-BB 4301500

1-phenyl-1H-pyrazole-4-carbaldehyde(SALTDATA: 0.2H2O)

1-Phenylpyrazole-4-carboxaldehyde

1-Phenyl-1H-pyrazol-4-carbaldehyde

1-Phenyl-1<i>H</i>-pyrazole-4-carboxaldehyde

1-phenypyrazole-4-carbaldehyde

54605-72-0

Azoles

blocks

Aldehydes

Building Blocks

C10-C12

Carbonyl Compounds

Chemical Synthesis

Organic Building Blocks