5-Bromoquinoline
- Product Name
- 5-Bromoquinoline
- CAS No.
- 4964-71-0
- Chemical Name
- 5-Bromoquinoline
- Synonyms
- 5-BromoquinoL;5-BROMOQUINOLINE;5-bronoquinoline;5-bromooquinoline;RARECHEM AK ML 0010;Quinoline, 5-bromo-;5-Bromoquinoline >5-Bromoquinoline,97%;5-Bromoquinoline 97%;5-Bromoquinoline,>98%
- CBNumber
- CB4149284
- Molecular Formula
- C9H6BrN
- Formula Weight
- 208.05
- MOL File
- 4964-71-0.mol
5-Bromoquinoline Property
- Melting point:
- 43-48 °C
- Boiling point:
- 105-107°C 1mm
- Density
- 1.5617 (rough estimate)
- refractive index
- 1.6641 (estimate)
- Flash point:
- 105-107°C/1mm
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- form
- powder to crystal
- pka
- 3.88±0.12(Predicted)
- color
- White to Light yellow to Green
- BRN
- 115148
- InChI
- InChI=1S/C9H6BrN/c10-8-4-1-5-9-7(8)3-2-6-11-9/h1-6H
- InChIKey
- CHODTZCXWXCALP-UHFFFAOYSA-N
- SMILES
- N1C2C(=C(Br)C=CC=2)C=CC=1
- CAS DataBase Reference
- 4964-71-0(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-20/21/22-22
- Safety Statements
- 26-36
- WGK Germany
- 3
- Hazard Note
- Irritant
- HS Code
- 29334900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- 714429
- Product name
- 5-Bromoquinoline
- Purity
- 97%
- Packaging
- 5g
- Price
- $178
- Updated
- 2025/07/31
- Product number
- B3078
- Product name
- 5-Bromoquinoline
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $50
- Updated
- 2025/07/31
- Product number
- B695903
- Product name
- 5-Bromoquinoline
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- B695903
- Product name
- 5-Bromoquinoline
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FB16134
- Product name
- 5-Bromoquinoline
- Packaging
- 5G
- Price
- $50
- Updated
- 2021/12/16
5-Bromoquinoline Chemical Properties,Usage,Production
Chemical Properties
White solid
Uses
5-Bromoquinoline is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
Preparation
5-Bromoquinoline can be prepared by the reaction of quinoline with dichloromethane and NBS.
Synthesis
611-34-7
4964-71-0
General procedure for the synthesis of 5-bromoquinoline from 5-aminoquinoline: 1. dissolve quinolin-5-amine (3.37 g, 23.38 mmol) in 9 mL of water and 11 mL of hydrogen bromide (48% aqueous solution), and the resulting solution is cooled to 0°C. 2. a solution of sodium nitrite (1.94 g, 28.12 mmol) dissolved in 9 mL of water was added slowly and dropwise. 3. the reaction mixture was stirred at room temperature for 5 minutes. 4. The above solution was added slowly dropwise to a pre-prepared solution of copper (I) bromide (4.02 g, 28.02 mmol dissolved in 23 mL of 48% aqueous hydrogen bromide). 5. The reaction mixture was stirred at 75°C for 2 hours. 6. Upon completion of the reaction, the reaction mixture was alkalized with sodium hydroxide solution. 7. The reaction mixture was extracted twice with ethyl acetate and the organic phases were combined. 8. The organic phase was washed sequentially with water and brine, and then dried over anhydrous sodium sulfate. 9. The desiccant was removed by filtration and the solvent was evaporated under reduced pressure to give 2.98 g (61% yield) of the target product 5-bromoquinoline. Product characterization data: 1H NMR (CDCl3) δ ppm: 7.44-7.63 (m, 2H), 7.84 (d, J = 7.42 Hz, 1H), 8.10 (d, J = 8.24 Hz, 1H), 8.56 (d, J = 8.51 Hz, 1H), 8.94 (br.s., 1H). HPLC/MS (9 min) retention time 5.68 min. Mass spectral data: m/z 208 (M), 210 (M+2).
References
[1] Bioorganic and medicinal chemistry, 2002, vol. 10, # 8, p. 2611 - 2623
[2] Patent: EP2394998, 2011, A1. Location in patent: Page/Page column 16
[3] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 5, p. 1472 - 1476
[4] Journal of Labelled Compounds and Radiopharmaceuticals, 1994, vol. 34, # 10, p. 905 - 913
[5] Patent: US2003/96826, 2003, A1
5-Bromoquinoline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Bromoquinoline manufacturers
- Product
- 5-Bromoquinoline 4964-71-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98% HPLC
- Supply Ability
- 2000tons
- Release date
- 2025-04-09
- Product
- 5-Bromoquinoline 4964-71-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-09-29
- Product
- 5-Bromoquinoline 4964-71-0
- Price
- US $1990.00/Kg
- Min. Order
- 1Kg
- Purity
- 98
- Supply Ability
- 500 Kg
- Release date
- 2024-04-01