4-BROMO-1-[(4-METHYLPHENYL)SULFONYL]-1H-PYRROLO[2,3-B]PYRIDINE

Product Name: 4-BROMO-1-[(4-METHYLPHENYL)SULFONYL]-1H-PYRROLO[2,3-B]PYRIDINE
CAS No.: 348640-07-3
Chemical Name: 4-BROMO-1-[(4-METHYLPHENYL)SULFONYL]-1H-PYRROLO[2,3-B]PYRIDINE
Synonyms: 4-Bormo-1-tosyl-7-azaindole;N-Tosyl-4-bromo-7-azaindole;4-BroMo-1-tosyl-7-azaindole;4-Bromo-1-tosyl-7-azaindo...;4-Bormo-1(N)-tosyl-7-azaindole;4-Bromo-1(n)-tosyl-7-azaindole;4-Bromo-1(n)-tosyl-7-azaindole 96%;4-Bromo-1-tosyl-1H-pyrrolo[2,3-b]pyridine;4-bromo-1-tosyl-1H-pyrrolo[2,4-b]pyridine;4-Bromo-1-(p-tolylsulfonyl)pyrrolo[2,3-b]pyridine
CBNumber: CB41500255
Molecular Formula: C14H11BrN2O2S
Formula Weight: 351.22
MOL File: 348640-07-3.mol

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4-BROMO-1-[(4-METHYLPHENYL)SULFONYL]-1H-PYRROLO[2,3-B]PYRIDINE Property

Boiling point:: 514.9±60.0 °C(Predicted)
Density: 1.59±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 2.14±0.30(Predicted)
Appearance: Off-white to yellow Solid

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Safety

RIDADR: UN2811
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

warning

Hazard statements

H303May be harmfulif swallowed

H313May be harmful in contact with skin

H333May be harmful if inhaled

Precautionary statements

P304+P312IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FB144066
Product name: 4-Bromo-1-tosyl-1H-pyrrolo[2,3-b]pyridine
Packaging: 250mg
Price: $62.5
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB144066
Product name: 4-Bromo-1-tosyl-1H-pyrrolo[2,3-b]pyridine
Packaging: 500mg
Price: $110
Updated: 2021/12/16

AK Scientific

Product number: W5651
Product name: 4-Bromo-1-tosyl-1H-pyrrolo[2,3-b]pyridine
Packaging: 250mg
Price: $118
Updated: 2021/12/16

SynQuest Laboratories

Product number: 8H69-9-10
Product name: 4-Bromo-1-[(4-methylbenzene)sulfonyl]pyrrolo[2,3-b]pyridine
Packaging: 1g
Price: $180
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB144066
Product name: 4-Bromo-1-tosyl-1H-pyrrolo[2,3-b]pyridine
Packaging: 1g
Price: $189
Updated: 2021/12/16

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4-BROMO-1-[(4-METHYLPHENYL)SULFONYL]-1H-PYRROLO[2,3-B]PYRIDINE Chemical Properties,Usage,Production

Synthesis

98-59-9

348640-06-2

348640-07-3

4-Bromo-7-azaindole (3 g, 15.22 mmol) was used as starting material and dissolved in tetrahydrofuran (THF, 50 mL) under nitrogen protection in a round bottom flask. The reaction mixture was cooled to 0 °C and sodium hydride (60% dispersed in mineral oil, 0.67 g, 16.75 mmol) was added in batches, and the outgassing phenomenon was observed during the addition. After the addition, the reaction mixture was stirred at room temperature for 30 min. Subsequently, p-toluenesulfonyl chloride (2.14 mL, 16.75 mmol) was slowly added to the reaction system. The reaction mixture was gradually warmed up to room temperature and stirring was continued for 2 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure and the residue was dissolved with dichloromethane (DCM, 30 mL). The organic phase was washed with 2 M sodium carbonate solution (2 x 30 mL), dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated to give an orange colored oil. Purification was carried out by fast column chromatography with the eluent ethyl acetate:cyclohexane (1:9, v/v) to afford the target compound 4-bromo-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-B]pyridine as an off-white solid in 92% yield. The product was analyzed by LCMS (Method 5, retention time 5.36 min, molecular ion peak m/z 337 [M + H]+) and 1H NMR (500 MHz, CDCl3) to confirm the structure: δ 8.22 (d, 1H), 8.18 (d, 2H), 7.78 (d, 1H), 7.58 (t, 1H), 7.48 (t, 2H), 7.35 (d , 1H), 6.63 (d, 1H).

References

[1] Tetrahedron Letters, 2016, vol. 57, # 42, p. 4718 - 4722
[2] Patent: US2015/274720, 2015, A1. Location in patent: Paragraph 0202
[3] Patent: US2011/306613, 2011, A1. Location in patent: Page/Page column 23
[4] Patent: WO2008/145688, 2008, A2. Location in patent: Page/Page column 42; 89
[5] Patent: WO2007/76320, 2007, A2. Location in patent: Page/Page column 34-35

4-BROMO-1-[(4-METHYLPHENYL)SULFONYL]-1H-PYRROLO[2,3-B]PYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-BROMO-1-[(4-METHYLPHENYL)SULFONYL]-1H-PYRROLO[2,3-B]PYRIDINE Suppliers

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348640-07-3, 4-BROMO-1-[(4-METHYLPHENYL)SULFONYL]-1H-PYRROLO[2,3-B]PYRIDINERelated Search:

4-BROMO-1-(PHENYLSULFONYL)-1H-PYRROLO[2,3-B]PYRIDINE 1H-Pyrrolo[2,3-b]pyridine, 1-[(4-methylphenyl)sulfonyl]- 4-Bromo-7-azaindole 4-BROMO-1-[(4-METHYLPHENYL)SULFONYL]-1H-PYRROLO[2,3-B]PYRIDINE

4-BROMO-1-[(4-METHYLPHENYL)SULFONYL]-1H-PYRROLO[2,3-B]PYRIDINE

1H-Pyrrolo[2,3-b]pyridine, 4-bromo-1-[(4-methylphenyl)sulfonyl]-

N-Tosyl-4-bromo-7-azaindole

4-Bormo-1-tosyl-7-azaindole

4-Bromo-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine

4-Bromo-1-tosyl-1H-pyrrolo[2,3-b]pyridine

4-Bromo-1-tosyl-7-azaindo...

4-BroMo-1-tosyl-7-azaindole

4-Bromo-1-(p-tolylsulfonyl)pyrrolo[2,3-b]pyridine

4-bromo-1-(4-methylbenzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine

4-bromo-1-(4-methylphenyl)sulfonylpyrrolo[2,3-b]pyridine

4-Bromo-1(n)-tosyl-7-azaindole 96%

4-Bromo-1-[(4-methylbenzene)sulfonyl]pyrrolo[2,3-b]pyridine

4-Bormo-1(N)-tosyl-7-azaindole

4-BROMO-1-[(4-METHYLPHENYL)SULFONYL]-1H-PYRROLO[2,3-B]PY

4-bromo-1-tosyl-1H-pyrrolo[2,4-b]pyridine

4-Bromo-1(n)-tosyl-7-azaindole

348640-07-3

Heterocycle-Pyridine series