4-Amino-3,5-dichloropyridine N-oxide

Preparation

Product Name: 4-Amino-3,5-dichloropyridine N-oxide
CAS No.: 91872-02-5
Chemical Name: 4-Amino-3,5-dichloropyridine N-oxide
Synonyms: Roflumilast Impurity 17;4-Amino-3,5-dichloropyridine 1-oxide;4-Amino-3,5-dichloropyridine N-oxide;3,5-dichloro-4-aminopyridine 1-oxide;4-Pyridinamine, 3,5-dichloro-, 1-oxide;4-amino-3,5-dichloropyridin-1-ium-1-olate;4-chloro-10-(cyclopropylmethoxy)-9-(difluoromethoxy)benzo[c][1,6]naphthyridin-6(5H)-one
CBNumber: CB41501469
Molecular Formula: C5H4Cl2N2O
Formula Weight: 179
MOL File: 91872-02-5.mol

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4-Amino-3,5-dichloropyridine N-oxide Property

Melting point:: 210 °C (decomp)
Boiling point:: 391.6±37.0 °C(Predicted)
Density: 1.66±0.1 g/cm3(Predicted)
pka: 2.25±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: A632005
Product name: 4-Amino-3,5-dichloropyridineN-Oxide
Packaging: 10mg
Price: $285
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0358694
Product name: 4-AMINO-3,5-DICHLOROPYRIDIN-1-IUM-1-OLATE
Purity: 95.00%
Packaging: 5MG
Price: $500.21
Updated: 2021/12/16

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4-Amino-3,5-dichloropyridine N-oxide Chemical Properties,Usage,Production

Preparation

4-amino-3,5-dichloropyridine-N-oxide is prepared by the following steps:A sealed Carius tube containing 4-nitro-3,5-dichloropyridine-N-oxide (36) (0.4 g, 1.9 mmol), aqueous ammonia (1 cm3 of 0.88 gi-l solution) and acetonitrile (1 cm3) was heated in a rotating oil bath at 70 OC for 3 h. The mixture was filtered giving a solid (0.1 g) and a filtrate, which was extracted into DCM, dried (MgS04) and evaporated giving a residue (0.0 g). The solid obtained from the filtration was recrystallised from hot methanol giving 4-amino-3,5-dichloropyridine-N-oxide (0.1 g, 30%), m.p. 210 oC from MeOH) (M+ found 177.9701. C5H4Cl2N20 requires M+ 177.9701); IR spectra no. 30; mass spectra no. 37; nmr spectrum no. 45.

Uses

4-Amino-3,5-dichloropyridine N-Oxide is the impurity of the drug Roflumilast (R639700), which is a selective phosphodiesterase 4(PDE4) inhibitor, antiasthmatic.

4-Amino-3,5-dichloropyridine N-oxide Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Amino-3,5-dichloropyridine N-oxide

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91872-02-5

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