ChemicalBook > CAS DataBase List > 2-Bromo-6-chloropyridin-3-amine

2-Bromo-6-chloropyridin-3-amine

Product Name: 2-Bromo-6-chloropyridin-3-amine
CAS No.: 1050501-88-6
Chemical Name: 2-Bromo-6-chloropyridin-3-amine
Synonyms: 2-Bromo-6-chloro-3-pyridinamine;2-Bromo-6-chloropyridin-3-amine;2-bromo-3-amino-6-chloropyridine;3-AMINO-6-CHLORO-2-BROMOPYRIDINE;3-Amino-2-bromo-6-chloropyridine;3-Pyridinamine, 2-bromo-6-chloro-;2-Bromo-6-chloro-pyridin-3-ylamine;2-Bromo-6-chloropyridin-3-amine ISO 9001：2015 REACH
CBNumber: CB41503175
Molecular Formula: C5H4BrClN2
Formula Weight: 207.46
MOL File: 1050501-88-6.mol

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2-Bromo-6-chloropyridin-3-amine Property

Boiling point:: 330.3±37.0 °C(Predicted)
Density: 1.834
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: -0.12±0.10(Predicted)
Appearance: Light brown to brown Solid
InChI: InChI=1S/C5H4BrClN2/c6-5-3(8)1-2-4(7)9-5/h1-2H,8H2
InChIKey: OPKKXWUGXHSFQI-UHFFFAOYSA-N
SMILES: C1C=C(N)C(Br)=NC=1Cl

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B429785
Product name: 2-Bromo-6-chloro-3-pyridinamine
Packaging: 1g
Price: $40
Updated: 2021/12/16

TRC

Product number: B429785
Product name: 2-Bromo-6-chloro-3-pyridinamine
Packaging: 5g
Price: $110
Updated: 2021/12/16

Matrix Scientific

Product number: 071068
Product name: 2-Bromo-6-chloropyridin-3-amine
Purity: 97%
Packaging: 1g
Price: $110
Updated: 2021/12/16

Apolloscientific

Product number: OR345185
Product name: 3-Amino-2-bromo-6-chloropyridine
Packaging: 1g
Price: $57
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H30-D-28
Product name: 3-Amino-2-bromo-6-chloropyridine
Purity: 97%
Packaging: 1g
Price: $68
Updated: 2021/12/16

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2-Bromo-6-chloropyridin-3-amine Chemical Properties,Usage,Production

Uses

2-Bromo-6-chloro-3-pyridinamine is a reactant used in the synthesis of kilogram quantities of an akt Kinase inhibitor. It is mainly used as starting material for the production of many pharmaceutical compounds.

Synthesis

5350-93-6

1050501-88-6

Step 1: Synthesis of 2-bromo-6-chloropyridin-3-amine Bromine (24.86 g, 155.57 mmol) was slowly added to a solution of acetic acid (383 mL) containing 6-chloropyridin-3-amine (20.00 g, 155.57 mmol) and sodium acetate (25.52 g, 311.14 mmol). The reaction mixture was stirred at room temperature for 1 hour. Subsequently, the acetic acid was removed by rotary evaporator. The residue was dissolved in ethyl acetate (EtOAc) and washed sequentially with saturated aqueous sodium carbonate (Na2CO3) solution, water and brine. The organic layer was dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated to afford the target product 2-bromo-6-chloropyridin-3-amine (32.20 g, 99.8% yield). Mass spectrometry analysis showed m/z = 206.96 ([M+H]+), which is consistent with the isotopic distribution pattern of Cl and Br.

References

[1] Patent: WO2012/80450, 2012, A1. Location in patent: Page/Page column 25
[2] Patent: WO2013/186335, 2013, A1. Location in patent: Page/Page column 87
[3] Patent: WO2013/186333, 2013, A1. Location in patent: Page/Page column 102
[4] Patent: WO2014/60411, 2014, A1. Location in patent: Page/Page column 56
[5] Patent: US2015/111868, 2015, A1. Location in patent: Paragraph 0856; 0857

2-Bromo-6-chloropyridin-3-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Bromo-6-chloropyridin-3-amine manufacturers

Dideu Industries Group Limited

Product: 2-Bromo-6-chloropyridin-3-amine 1050501-88-6
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-09-03

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1050501-88-6