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2-Bromo-6-chloropyridin-3-amine

Product Name
2-Bromo-6-chloropyridin-3-amine
CAS No.
1050501-88-6
Chemical Name
2-Bromo-6-chloropyridin-3-amine
Synonyms
2-Bromo-6-chloro-3-pyridinamine;2-Bromo-6-chloropyridin-3-amine;2-bromo-3-amino-6-chloropyridine;3-AMINO-6-CHLORO-2-BROMOPYRIDINE;3-Amino-2-bromo-6-chloropyridine;3-Pyridinamine, 2-bromo-6-chloro-;2-Bromo-6-chloro-pyridin-3-ylamine;2-Bromo-6-chloropyridin-3-amine ISO 9001：2015 REACH
CBNumber
CB41503175
Molecular Formula
C5H4BrClN2
Formula Weight
207.46
MOL File
1050501-88-6.mol
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2-Bromo-6-chloropyridin-3-amine Property

Boiling point:
330.3±37.0 °C(Predicted)
Density 
1.834
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
-0.12±0.10(Predicted)
Appearance
Light brown to brown Solid
InChI
InChI=1S/C5H4BrClN2/c6-5-3(8)1-2-4(7)9-5/h1-2H,8H2
InChIKey
OPKKXWUGXHSFQI-UHFFFAOYSA-N
SMILES
C1C=C(N)C(Br)=NC=1Cl
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B429785
Product name
2-Bromo-6-chloro-3-pyridinamine
Packaging
1g
Price
$40
Updated
2021/12/16
TRC
Product number
B429785
Product name
2-Bromo-6-chloro-3-pyridinamine
Packaging
5g
Price
$110
Updated
2021/12/16
Matrix Scientific
Product number
071068
Product name
2-Bromo-6-chloropyridin-3-amine
Purity
97%
Packaging
1g
Price
$110
Updated
2021/12/16
Apolloscientific
Product number
OR345185
Product name
3-Amino-2-bromo-6-chloropyridine
Packaging
1g
Price
$57
Updated
2021/12/16
SynQuest Laboratories
Product number
3H30-D-28
Product name
3-Amino-2-bromo-6-chloropyridine
Purity
97%
Packaging
1g
Price
$68
Updated
2021/12/16
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2-Bromo-6-chloropyridin-3-amine Chemical Properties,Usage,Production

Uses

2-Bromo-6-chloro-3-pyridinamine is a reactant used in the synthesis of kilogram quantities of an akt Kinase inhibitor. It is mainly used as starting material for the production of many pharmaceutical compounds.

Synthesis

5350-93-6

1050501-88-6

Step 1: Synthesis of 2-bromo-6-chloropyridin-3-amine Bromine (24.86 g, 155.57 mmol) was slowly added to a solution of acetic acid (383 mL) containing 6-chloropyridin-3-amine (20.00 g, 155.57 mmol) and sodium acetate (25.52 g, 311.14 mmol). The reaction mixture was stirred at room temperature for 1 hour. Subsequently, the acetic acid was removed by rotary evaporator. The residue was dissolved in ethyl acetate (EtOAc) and washed sequentially with saturated aqueous sodium carbonate (Na2CO3) solution, water and brine. The organic layer was dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated to afford the target product 2-bromo-6-chloropyridin-3-amine (32.20 g, 99.8% yield). Mass spectrometry analysis showed m/z = 206.96 ([M+H]+), which is consistent with the isotopic distribution pattern of Cl and Br.

References

[1] Patent: WO2012/80450, 2012, A1. Location in patent: Page/Page column 25
[2] Patent: WO2013/186335, 2013, A1. Location in patent: Page/Page column 87
[3] Patent: WO2013/186333, 2013, A1. Location in patent: Page/Page column 102
[4] Patent: WO2014/60411, 2014, A1. Location in patent: Page/Page column 56
[5] Patent: US2015/111868, 2015, A1. Location in patent: Paragraph 0856; 0857

2-Bromo-6-chloropyridin-3-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Bromo-6-chloropyridin-3-amine Suppliers

China 98 Germany 2 India 1 United States 10 Global 111
NovoChemy Ltd.
Tel
021-31261262/ 49 (0)17662837245
Fax
(0)21-33250524
Email
sales@novochemy.com
Country
Germany
ProdList
6328
Advantage
58
WeylChem GmbH
Tel
--
Fax
--
Country
Germany
ProdList
396
Advantage
64
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View Lastest Price from 2-Bromo-6-chloropyridin-3-amine manufacturers

Dideu Industries Group Limited
Product
2-Bromo-6-chloropyridin-3-amine 1050501-88-6
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons min
Release date
2021-09-03

1050501-88-6, 2-Bromo-6-chloropyridin-3-amineRelated Search:

2-BROMO-6-CHLOROPYRIDINE

  • 2-Bromo-6-chloropyridin-3-amine
  • 3-Amino-2-bromo-6-chloropyridine
  • 3-AMINO-6-CHLORO-2-BROMOPYRIDINE
  • 2-Bromo-6-chloro-3-pyridinamine
  • 2-Bromo-6-chloro-pyridin-3-ylamine
  • 3-Pyridinamine, 2-bromo-6-chloro-
  • 2-Bromo-6-chloropyridin-3-amine ISO 9001：2015 REACH
  • 2-bromo-3-amino-6-chloropyridine
  • 1050501-88-6