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ISOXANTHOHUMOL

Product Name
ISOXANTHOHUMOL
CAS No.
521-48-2
Chemical Name
ISOXANTHOHUMOL
Synonyms
ISOXANTHOHUMOL;4',7-DIHYDROXY-5-METHOXY-8-PRENYLFLAVANONE;4',7-Dihydroxy-5-methoxy-8-(3-methyl-2-butenyl)flavanone;2,3-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-5-methoxy-8-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one;2-(4-Hydroxyphenyl)-5-methoxy-7-hydroxy-8-(3-methyl-2-butenyl)-2,3-dihydro-4H-1-benzopyran-4-one;2,3-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-5-methoxy-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 2,3-dihydro-7-hydroxy-2-(4-hydroxyphenyl)-5-methoxy-8-(3-methyl-2-buten-1-yl)-
CBNumber
CB4150547
Molecular Formula
C21H22O5
Formula Weight
354.4
MOL File
521-48-2.mol
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ISOXANTHOHUMOL Property

Melting point:
183 - 187°
Boiling point:
585.8±50.0 °C(Predicted)
Density 
1.245±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
powder
pka
7.90±0.40(Predicted)
color 
Pale Yellow
BRN 
10199264
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SMB00389
Product name
Isoxanthohumol
Purity
≥99% (HPLC)
Packaging
1mg
Price
$120
Updated
2024/03/01
Sigma-Aldrich
Product number
55423
Product name
Isoxanthohumol
Purity
analytical standard
Packaging
5mg
Price
$513
Updated
2022/05/15
Cayman Chemical
Product number
23233
Product name
Isoxanthohumol
Purity
≥98%
Packaging
500μg
Price
$35
Updated
2024/03/01
Cayman Chemical
Product number
23233
Product name
Isoxanthohumol
Purity
≥98%
Packaging
1mg
Price
$63
Updated
2024/03/01
Cayman Chemical
Product number
23233
Product name
Isoxanthohumol
Purity
≥98%
Packaging
5mg
Price
$245
Updated
2024/03/01
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ISOXANTHOHUMOL Chemical Properties,Usage,Production

Description

Isoxanthohumol is a natural, prenylated chalcone isolated from the hop plant, H. lupulus (hops). It has diverse biological activities, including antiproliferative, anti-inflammatory, and antiviral properties. In B16 and A375 melanoma cells, isoxanthohumol inhibits proliferation (IC50s = 22.15 and 22.9 μM in an MTT assay), slows cell division, and induces apoptosis. Isoxanthohumol reversibly inhibits Kv1.3 channels with an EC50 value of 7.8 μM in human Jurkat T cells using patch clamp electrophysiology. It has strong deterrent properties against the peach potato aphid. It has also been used as a marker of beer consumption. Isoxanthohumol is metabolized in the liver and intestine to 8-prenylnaringenin , a potent phytoestrogen.

Uses

Isoxanthohumol is a prenylated flavone isolated from hop. A chromane-like cyclic prenylflavonoids for neurological disorder therapy. Isoxanthohumol is a prenylated flavonoid phytoestrogen which is an apoptosis inducer in mature adipocytes

Definition

ChEBI: Isoxanthohumol is a member of flavanones.

ISOXANTHOHUMOL Preparation Products And Raw materials

Raw materials

Preparation Products

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ISOXANTHOHUMOL Suppliers

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521-48-2, ISOXANTHOHUMOLRelated Search:

ISOPIMPINELLIN 2-(3-Methoxy-4-hydroxyphenyl)-6-α-D-glucopyranosyl-5,7-dihydroxy-4H-1-benzopyran-4-one (+/-)-8-PRENYLNARINGENIN ISOXANTHOHUMOL(NEW)(PRIMARY STANDARD) ISOXANTHOHUMOL(NEW)(P) Isoxanthohumol【Helichrysum】

  • ISOXANTHOHUMOL
  • 4',7-DIHYDROXY-5-METHOXY-8-PRENYLFLAVANONE
  • 2-(4-Hydroxyphenyl)-5-methoxy-7-hydroxy-8-(3-methyl-2-butenyl)-2,3-dihydro-4H-1-benzopyran-4-one
  • 2,3-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-5-methoxy-8-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one
  • 2,3-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-5-methoxy-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one
  • 4',7-Dihydroxy-5-methoxy-8-(3-methyl-2-butenyl)flavanone
  • 4H-1-Benzopyran-4-one, 2,3-dihydro-7-hydroxy-2-(4-hydroxyphenyl)-5-methoxy-8-(3-methyl-2-buten-1-yl)-
  • 521-48-2