ChemicalBook > CAS DataBase List > avosentan

avosentan

Product Name
avosentan
CAS No.
290815-26-8
Chemical Name
avosentan
Synonyms
CS-644;SPP-301;avosentan;Ro 67-0565;Avosentan (SPP301);RO 67-0565; SPP-301;Avosentan (Ro 67-0565;avosentan,CID 9912992;Avosentan, 10 mM in DMSO;inhibit,SPP 301,Inhibitor,Avosentan,SPP301,Endothelin Receptor
CBNumber
CB41508589
Molecular Formula
C23H21N5O5S
Formula Weight
479.51
MOL File
290815-26-8.mol
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avosentan Property

Boiling point:
575.5±60.0 °C(Predicted)
Density 
1.363
storage temp. 
Store at -20°C
solubility 
DMSO : 6.67 mg/mL (13.91 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
form 
Powder
pka
3.19±0.10(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
A794710
Product name
Avosentan
Packaging
10mg
Price
$165
Updated
2021/12/16
Usbiological
Product number
002983
Product name
Avosentan
Packaging
10mg
Price
$460
Updated
2021/12/16
ChemScene
Product number
CS-0625
Product name
Avosentan
Purity
98.36%
Packaging
10mg
Price
$180
Updated
2021/12/16
Matrix Scientific
Product number
098678
Product name
N-(6-Methoxy-5-(2-methoxyphenoxy)-2-(pyridin-4-yl)-pyrimidin-4-yl)-5-methylpyridine-2-sulfonamide
Purity
95+%
Packaging
250mg
Price
$742
Updated
2021/12/16
ChemScene
Product number
CS-0625
Product name
Avosentan
Purity
98.36%
Packaging
50mg
Price
$840
Updated
2021/12/16
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avosentan Chemical Properties,Usage,Production

Uses

Avosentan is a competitive antagonist of Endothelin-1 (ET-1) with a high selectivity for the ETA receptor. Avosentan may be a potential option in the treatment of glaucoma.

Enzyme inhibitor

This potent, selective and orally available endothelin A receptor blocker (FW = 479.51 g/mol; CAS 290815-26-8; Soluble in DMSO), also known by its code names SPP301 and Ro 67-0565, induces the dose-dependent reduction in the fractional renal excretion of sodium (up to 8.7% at 50 mg avosentan), with a paralleled dose-related increase in proximal sodium reabsorption. Avosentan reduces albuminuria, when added to standard treatment in patients with type 2 diabetes and overt nephropathy, but induces significant fluid overload and congestive heart failure.

avosentan Preparation Products And Raw materials

Raw materials

Preparation Products

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290815-26-8, avosentanRelated Search:

p-Anisidine 5-METHYL-N,N-DIMETHYLTRYPTAMINE N-Methoxyphthalimide 4-Methoxybenzyl cyanide

  • N-(6-Methoxy-5-(2-methoxyphenoxy)-2-(pyridin-4-yl)-pyrimidin-4-yl)-5-methylpyridine-2-sulfonamide
  • N-(6-Methoxy-5-(2-methoxyphenoxy)-2-(pyridin-4-yl)-pyrimidin-4-yl)-5-methylpyridine-2-sulfonam
  • 2-Pyridinesulfonamide,N-[6-methoxy-5-(2-methoxyphenoxy)-2-(4-pyridinyl)-4-pyrimidinyl]-5-methyl-
  • avosentan,CID 9912992
  • avosentan
  • N-[6-Methoxy-5-(2-methoxyphenoxy)-2-(4-pyridinyl)-4-pyrimidinyl]-5-methyl-2-pyridinesulfonamide
  • Ro 67-0565
  • SPP-301
  • Avosentan (SPP301)
  • RO 67-0565; SPP-301
  • Avosentan (Ro 67-0565
  • CS-644
  • inhibit,SPP 301,Inhibitor,Avosentan,SPP301,Endothelin Receptor
  • Avosentan, 10 mM in DMSO
  • 290815-26-8
  • C23H21N5O5S