avosentan

ChemicalBook > CAS DataBase List > avosentan

Product Name: avosentan
CAS No.: 290815-26-8
Chemical Name: avosentan
Synonyms: CS-644;SPP-301;avosentan;Ro 67-0565;Avosentan (SPP301);RO 67-0565; SPP-301;Avosentan (Ro 67-0565;avosentan,CID 9912992;inhibit,SPP 301,Inhibitor,Avosentan,SPP301,Endothelin Receptor;N-(6-Methoxy-5-(2-methoxyphenoxy)-2-(pyridin-4-yl)-pyrimidin-4-yl)-5-methylpyridine-2-sulfonam
CBNumber: CB41508589
Molecular Formula: C23H21N5O5S
Formula Weight: 479.51
MOL File: 290815-26-8.mol

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avosentan Property

Boiling point:: 575.5±60.0 °C(Predicted)
Density: 1.363
storage temp.: Store at -20°C
solubility: DMSO : 6.67 mg/mL (13.91 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
form: Powder
pka: 3.19±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: A794710
Product name: Avosentan
Packaging: 10mg
Price: $165
Updated: 2021/12/16

Usbiological

Product number: 002983
Product name: Avosentan
Packaging: 10mg
Price: $460
Updated: 2021/12/16

ChemScene

Product number: CS-0625
Product name: Avosentan
Purity: 98.36%
Packaging: 5mg
Price: $132
Updated: 2021/12/16

ChemScene

Product number: CS-0625
Product name: Avosentan
Purity: 98.36%
Packaging: 10mg
Price: $180
Updated: 2021/12/16

Matrix Scientific

Product number: 098678
Product name: N-(6-Methoxy-5-(2-methoxyphenoxy)-2-(pyridin-4-yl)-pyrimidin-4-yl)-5-methylpyridine-2-sulfonamide
Purity: 95+%
Packaging: 250mg
Price: $742
Updated: 2021/12/16

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avosentan Chemical Properties,Usage,Production

Uses

Avosentan is a competitive antagonist of Endothelin-1 (ET-1) with a high selectivity for the ETA receptor. Avosentan may be a potential option in the treatment of glaucoma.

Enzyme inhibitor

This potent, selective and orally available endothelin A receptor blocker (FW = 479.51 g/mol; CAS 290815-26-8; Soluble in DMSO), also known by its code names SPP301 and Ro 67-0565, induces the dose-dependent reduction in the fractional renal excretion of sodium (up to 8.7% at 50 mg avosentan), with a paralleled dose-related increase in proximal sodium reabsorption. Avosentan reduces albuminuria, when added to standard treatment in patients with type 2 diabetes and overt nephropathy, but induces significant fluid overload and congestive heart failure.

avosentan Preparation Products And Raw materials

Raw materials

Preparation Products

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avosentan Suppliers

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290815-26-8, avosentanRelated Search:

p-Anisidine 5-METHYL-N,N-DIMETHYLTRYPTAMINE N-Methoxyphthalimide 4-Methoxybenzyl cyanide

N-(6-Methoxy-5-(2-methoxyphenoxy)-2-(pyridin-4-yl)-pyrimidin-4-yl)-5-methylpyridine-2-sulfonamide

N-(6-Methoxy-5-(2-methoxyphenoxy)-2-(pyridin-4-yl)-pyrimidin-4-yl)-5-methylpyridine-2-sulfonam

2-Pyridinesulfonamide,N-[6-methoxy-5-(2-methoxyphenoxy)-2-(4-pyridinyl)-4-pyrimidinyl]-5-methyl-

avosentan,CID 9912992

avosentan

N-[6-Methoxy-5-(2-methoxyphenoxy)-2-(4-pyridinyl)-4-pyrimidinyl]-5-methyl-2-pyridinesulfonamide

Ro 67-0565

SPP-301

Avosentan (SPP301)

RO 67-0565; SPP-301

Avosentan (Ro 67-0565

CS-644

inhibit,SPP 301,Inhibitor,Avosentan,SPP301,Endothelin Receptor

290815-26-8

C23H21N5O5S