1-N-Boc-3-(S)-Methylamino-piperidine

Product Name: 1-N-Boc-3-(S)-Methylamino-piperidine
CAS No.: 912368-73-1
Chemical Name: 1-N-Boc-3-(S)-Methylamino-piperidine
Synonyms: S-N-Boc-3-MethylaMino piperidine;N-Boc-3-(S)-Methylamino-piperidine;(S)-1-Boc-3-(MethylaMino)piperidine;(S)-1-N-BOC-3-METHYLAMINOPIPERIDINE;1-N-Boc-3-(S)-Methylamino-piperidine;(S)-1-Boc-3-(methylamino)piperidine 97%;(S)-1-Boc-3-(methylamino)piperidine;(S)-tert-Butyl 3-(MethylaMino)piperidine-1-carboxylate;tert-Butyl (S)-3-(methylamino)piperidine-1-carboxylate;Tert-butyl (3s)-3-(methylamino)piperidine-1-carboxylate
CBNumber: CB41508675
Molecular Formula: C11H22N2O2
Formula Weight: 214.3
MOL File: 912368-73-1.mol

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1-N-Boc-3-(S)-Methylamino-piperidine Property

Boiling point:: 289℃
Density: 1.01
Flash point:: 129℃
refractive index: 1.4600
storage temp.: 2-8°C
form: Liquid
pka: 10.10±0.20(Predicted)
color: Colorless to yellow
optical activity: 13.3°(C=1.00g/100mL CHCL3)
Sensitive: Moisture Sensitive

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Safety

Hazard Codes: T,N
Risk Statements: 25-36-50
Safety Statements: 26-45-61
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3
HazardClass: 6.1
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H319Causes serious eye irritation

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 735833
Product name: (S)-1-Boc-3-(methylamino)piperidine
Purity: 97%
Packaging: 500mg
Price: $156
Updated: 2023/01/07

TRC

Product number: B663305
Product name: (S)-1-N-Boc-3-Methylaminopiperidine
Packaging: 500mg
Price: $130
Updated: 2021/12/16

Activate Scientific

Product number: AS37176
Product name: (S)-1-N-Boc-3-Methylaminopiperidine
Purity: 95+% ee
Packaging: 250mg
Price: $59
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB142858
Product name: (S)-tert-Butyl 3-(methylamino)piperidine-1-carboxylate
Packaging: 250mg
Price: $82.5
Updated: 2021/12/16

Chem-Impex

Product number: 41506
Product name: (S)-1-Boc-3-(methylamino)piperidine,96.5%(GC)
Purity: 96.5%(GC)
Packaging: 500MG
Price: $104.16
Updated: 2021/12/16

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1-N-Boc-3-(S)-Methylamino-piperidine Chemical Properties,Usage,Production

Synthesis

50-00-0

625471-18-3

912368-73-1

General procedure for the synthesis of 1-N-BOC-3-(S)-methylaminopiperidine from formaldehyde and (S)-1-Boc-3-aminopiperidine: tert-butyl (5.0 g, 25 mmol) of (S)-3-aminopiperidine-1-carboxylate (5.0 g, 25 mmol) was added to a stirred aqueous formaldehyde (1.85 mL, 25 mmol, 37%) and suspension of molecular sieves in methanol and the reaction mixture was stirred at room temperature (24 °C) the reaction mixture was stirred for 24 hours. Subsequently, sodium borohydride (1.52 g, 40 mmol) was slowly added to the above mixture at room temperature and stirring was continued for 16 hours. Upon completion of the reaction, the reaction was quenched by the addition of ice water (30 mL) and extracted with ethyl acetate (3 x 100 mL). The organic phases were combined, dried with anhydrous sodium sulfate, and concentrated under reduced pressure to afford 3.0 g of the crude product (S)-tert-butyl 3-(methylamino)piperidine-1-carboxylate as a light yellow liquid, which was used directly in the next step of the reaction.1H NMR (400 MHz, CDCl3) δ ppm: 1.38 (s, 9H), 1.5-1.7 (m, 4H), 1.71-1.90 (m 2H), 2.18-2.27 (m, 3H), 2.75-2.90 (m, 1H), 3.50-3.92 (m, 2H).

References

[1] Journal of Medicinal Chemistry, 2018, vol. 61, # 3, p. 1061 - 1073
[2] Patent: WO2018/2437, 2018, A1. Location in patent: Page/Page column 99

1-N-Boc-3-(S)-Methylamino-piperidine Preparation Products And Raw materials

Raw materials

Preparation Products

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1-N-Boc-3-(S)-Methylamino-piperidine Suppliers

China 64 India 2 United Kingdom 1 United States 7 Global 74

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View Lastest Price from 1-N-Boc-3-(S)-Methylamino-piperidine manufacturers

Career Henan Chemical Co

Product: 1-N-Boc-3-(S)-Methylamino-piperidine 912368-73-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-01-09

912368-73-1, 1-N-Boc-3-(S)-Methylamino-piperidineRelated Search:

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1-N-Boc-3-(S)-Methylamino-piperidine

tert-Butyl (S)-3-(methylamino)piperidine-1-carboxylate

(S)-1-N-BOC-3-METHYLAMINOPIPERIDINE

Tert-butyl (3s)-3-(methylamino)piperidine-1-carboxylate

(S)-1-Boc-3-(MethylaMino)piperidine

(S)-tert-Butyl 3-(MethylaMino)piperidine-1-carboxylate

S-N-Boc-3-MethylaMino piperidine

(S)-1-Boc-3-(methylamino)piperidine 97%

N-Boc-3-(S)-Methylamino-piperidine

1-Piperidinecarboxylic acid, 3-(methylamino)-, 1,1-dimethylethyl ester, (3S)-

(S)-TERT-BUTYL 3-(METHYLAMINO)PIPERIDINE-1-CARBOXYLATE - PRODUCT

(<i>S</i>)-1-Boc-3-(methylamino)piperidine

912368-73-1

Piperidine