1-N-Boc-3-(S)-Methylamino-piperidine
- Product Name
- 1-N-Boc-3-(S)-Methylamino-piperidine
- CAS No.
- 912368-73-1
- Chemical Name
- 1-N-Boc-3-(S)-Methylamino-piperidine
- Synonyms
- S-N-Boc-3-MethylaMino piperidine;N-Boc-3-(S)-Methylamino-piperidine;(S)-1-Boc-3-(MethylaMino)piperidine;(S)-1-N-BOC-3-METHYLAMINOPIPERIDINE;1-N-Boc-3-(S)-Methylamino-piperidine;(S)-1-Boc-3-(methylamino)piperidine 97%;(S)-1-Boc-3-(methylamino)piperidine;(S)-tert-Butyl 3-(MethylaMino)piperidine-1-carboxylate;tert-Butyl (S)-3-(methylamino)piperidine-1-carboxylate;Tert-butyl (3s)-3-(methylamino)piperidine-1-carboxylate
- CBNumber
- CB41508675
- Molecular Formula
- C11H22N2O2
- Formula Weight
- 214.3
- MOL File
- 912368-73-1.mol
1-N-Boc-3-(S)-Methylamino-piperidine Property
- Boiling point:
- 289℃
- Density
- 1.01
- Flash point:
- 129℃
- refractive index
- 1.4600
- storage temp.
- 2-8°C
- form
- Liquid
- pka
- 10.10±0.20(Predicted)
- color
- Colorless to yellow
- optical activity
- 13.3°(C=1.00g/100mL CHCL3)
- Sensitive
- Moisture Sensitive
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H319Causes serious eye irritation
H400Very toxic to aquatic life
- Precautionary statements
-
P273Avoid release to the environment.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 735833
- Product name
- (S)-1-Boc-3-(methylamino)piperidine
- Purity
- 97%
- Packaging
- 500mg
- Price
- $156
- Updated
- 2023/01/07
- Product number
- B663305
- Product name
- (S)-1-N-Boc-3-Methylaminopiperidine
- Packaging
- 500mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- FB142858
- Product name
- (S)-tert-Butyl 3-(methylamino)piperidine-1-carboxylate
- Packaging
- 500mg
- Price
- $145
- Updated
- 2021/12/16
- Product number
- W9364
- Product name
- (S)-1-N-Boc-3-Methylaminopiperidine
- Packaging
- 1g
- Price
- $391
- Updated
- 2021/12/16
- Product number
- FB142858
- Product name
- (S)-tert-Butyl 3-(methylamino)piperidine-1-carboxylate
- Packaging
- 2g
- Price
- $440
- Updated
- 2021/12/16
1-N-Boc-3-(S)-Methylamino-piperidine Chemical Properties,Usage,Production
Synthesis
50-00-0
625471-18-3
912368-73-1
General procedure for the synthesis of 1-N-BOC-3-(S)-methylaminopiperidine from formaldehyde and (S)-1-Boc-3-aminopiperidine: tert-butyl (5.0 g, 25 mmol) of (S)-3-aminopiperidine-1-carboxylate (5.0 g, 25 mmol) was added to a stirred aqueous formaldehyde (1.85 mL, 25 mmol, 37%) and suspension of molecular sieves in methanol and the reaction mixture was stirred at room temperature (24 °C) the reaction mixture was stirred for 24 hours. Subsequently, sodium borohydride (1.52 g, 40 mmol) was slowly added to the above mixture at room temperature and stirring was continued for 16 hours. Upon completion of the reaction, the reaction was quenched by the addition of ice water (30 mL) and extracted with ethyl acetate (3 x 100 mL). The organic phases were combined, dried with anhydrous sodium sulfate, and concentrated under reduced pressure to afford 3.0 g of the crude product (S)-tert-butyl 3-(methylamino)piperidine-1-carboxylate as a light yellow liquid, which was used directly in the next step of the reaction.1H NMR (400 MHz, CDCl3) δ ppm: 1.38 (s, 9H), 1.5-1.7 (m, 4H), 1.71-1.90 (m 2H), 2.18-2.27 (m, 3H), 2.75-2.90 (m, 1H), 3.50-3.92 (m, 2H).
References
[1] Journal of Medicinal Chemistry, 2018, vol. 61, # 3, p. 1061 - 1073
[2] Patent: WO2018/2437, 2018, A1. Location in patent: Page/Page column 99
1-N-Boc-3-(S)-Methylamino-piperidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-N-Boc-3-(S)-Methylamino-piperidine manufacturers
- Product
- 1-N-Boc-3-(S)-Methylamino-piperidine 912368-73-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-01-09