ChemicalBook > CAS DataBase List > 1-N-Boc-3-(S)-Methylamino-piperidine

1-N-Boc-3-(S)-Methylamino-piperidine

Product Name
1-N-Boc-3-(S)-Methylamino-piperidine
CAS No.
912368-73-1
Chemical Name
1-N-Boc-3-(S)-Methylamino-piperidine
Synonyms
S-N-Boc-3-MethylaMino piperidine;N-Boc-3-(S)-Methylamino-piperidine;(S)-1-Boc-3-(MethylaMino)piperidine;(S)-1-N-BOC-3-METHYLAMINOPIPERIDINE;1-N-Boc-3-(S)-Methylamino-piperidine;(S)-1-Boc-3-(methylamino)piperidine 97%;(S)-1-Boc-3-(methylamino)piperidine;(S)-tert-Butyl 3-(MethylaMino)piperidine-1-carboxylate;tert-Butyl (S)-3-(methylamino)piperidine-1-carboxylate;Tert-butyl (3s)-3-(methylamino)piperidine-1-carboxylate
CBNumber
CB41508675
Molecular Formula
C11H22N2O2
Formula Weight
214.3
MOL File
912368-73-1.mol
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1-N-Boc-3-(S)-Methylamino-piperidine Property

Boiling point:
289℃
Density 
1.01
Flash point:
129℃
refractive index 
1.4600
storage temp. 
2-8°C
form 
Liquid
pka
10.10±0.20(Predicted)
color 
Colorless to yellow
optical activity
13.3°(C=1.00g/100mL CHCL3)
Sensitive 
Moisture Sensitive
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Safety

Hazard Codes 
T,N
Risk Statements 
25-36-50
Safety Statements 
26-45-61
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
HazardClass 
6.1
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H319Causes serious eye irritation

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
735833
Product name
(S)-1-Boc-3-(methylamino)piperidine
Purity
97%
Packaging
500mg
Price
$156
Updated
2023/01/07
TRC
Product number
B663305
Product name
(S)-1-N-Boc-3-Methylaminopiperidine
Packaging
500mg
Price
$130
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB142858
Product name
(S)-tert-Butyl 3-(methylamino)piperidine-1-carboxylate
Packaging
500mg
Price
$145
Updated
2021/12/16
AK Scientific
Product number
W9364
Product name
(S)-1-N-Boc-3-Methylaminopiperidine
Packaging
1g
Price
$391
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB142858
Product name
(S)-tert-Butyl 3-(methylamino)piperidine-1-carboxylate
Packaging
2g
Price
$440
Updated
2021/12/16
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1-N-Boc-3-(S)-Methylamino-piperidine Chemical Properties,Usage,Production

Synthesis

50-00-0

625471-18-3

912368-73-1

General procedure for the synthesis of 1-N-BOC-3-(S)-methylaminopiperidine from formaldehyde and (S)-1-Boc-3-aminopiperidine: tert-butyl (5.0 g, 25 mmol) of (S)-3-aminopiperidine-1-carboxylate (5.0 g, 25 mmol) was added to a stirred aqueous formaldehyde (1.85 mL, 25 mmol, 37%) and suspension of molecular sieves in methanol and the reaction mixture was stirred at room temperature (24 °C) the reaction mixture was stirred for 24 hours. Subsequently, sodium borohydride (1.52 g, 40 mmol) was slowly added to the above mixture at room temperature and stirring was continued for 16 hours. Upon completion of the reaction, the reaction was quenched by the addition of ice water (30 mL) and extracted with ethyl acetate (3 x 100 mL). The organic phases were combined, dried with anhydrous sodium sulfate, and concentrated under reduced pressure to afford 3.0 g of the crude product (S)-tert-butyl 3-(methylamino)piperidine-1-carboxylate as a light yellow liquid, which was used directly in the next step of the reaction.1H NMR (400 MHz, CDCl3) δ ppm: 1.38 (s, 9H), 1.5-1.7 (m, 4H), 1.71-1.90 (m 2H), 2.18-2.27 (m, 3H), 2.75-2.90 (m, 1H), 3.50-3.92 (m, 2H).

References

[1] Journal of Medicinal Chemistry, 2018, vol. 61, # 3, p. 1061 - 1073
[2] Patent: WO2018/2437, 2018, A1. Location in patent: Page/Page column 99

1-N-Boc-3-(S)-Methylamino-piperidine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1-N-Boc-3-(S)-Methylamino-piperidine manufacturers

Career Henan Chemical Co
Product
1-N-Boc-3-(S)-Methylamino-piperidine 912368-73-1
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2020-01-09

912368-73-1, 1-N-Boc-3-(S)-Methylamino-piperidineRelated Search:

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